72297-14-4

Basic information

• Product Name: 4-[(2S,3R)-((1Z,3E,5E,8Z)-3-Tetradeca-1,3,5,8-tetraenyl)-oxiranyl]-butyric acid methyl ester
• CAS NO: 72297-14-4
• Molecular Weight: 332.483
• Mol File: 72297-14-4.mol
• Article Data: 10

Chemical Properties

• CAS DataBase Reference: 4-[(2S,3R)-((1Z,3E,5E,8Z)-3-Tetradeca-1,3,5,8-tetraenyl)-oxiranyl]-butyric acid methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 4-[(2S,3R)-((1Z,3E,5E,8Z)-3-Tetradeca-1,3,5,8-tetraenyl)-oxiranyl]-butyric acid methyl ester(72297-14-4)
• EPA Substance Registry System: 4-[(2S,3R)-((1Z,3E,5E,8Z)-3-Tetradeca-1,3,5,8-tetraenyl)-oxiranyl]-butyric acid methyl ester(72297-14-4)

Safety Data

• Hazardous Substances Data: 72297-14-4(Hazardous Substances Data)

Upstream product

• 89408-62-8 4-[3-((2Z,5Z,8Z)-1-Methanesulfonyloxy-tetradeca-2,5,8-trienyl)-oxiranyl]-butyric acid methyl ester 
• 73958-01-7 9-oxo-5,6-trans-epoxynon-7(E)-enoate 
• 73958-02-8 -triphenyl-phosphoran 
• 73958-01-7 methyl 8-formyl-5(S),6(S)-oxido-7(E)-octenoate 
• 73958-09-5 Phosphorane of (Z)-3-nonen-1-yl-triphenylphosponium bromide 
• 73958-00-6 4-[(2S,3R)-3-((1Z,3E)-5-Oxo-penta-1,3-dienyl)-oxiranyl]-butyric acid methyl ester 
• 80629-41-0 methyl ester of 5(S)-hydroperoxy-6(E)-8,11,14(Z)-eicosatetranoic acid 
• 75817-50-4 undeca-2c,5c-dien-1-ol 
• 35378-79-1 undeca-2,5-diyn-1-ol 
• 6026-86-4 methyl 4-formylbutanoate 
• 20739-58-6 2-octyn-1-ol 
• 18495-27-7 1-bromooct-2-yne 
• 73958-00-6 methyl 10-formyl-5,6E-epoxy-7E,9E-decadienoate 
• 89408-60-6 4-[3-((2Z,5Z,8Z)-1-Hydroxy-tetradeca-2,5,8-trienyl)-oxiranyl]-butyric acid methyl ester 

Downstream Products

• 73466-14-5 (7E,9E,11Z,14Z)-(5S,6R)-6-[(R)-2-((S)-4-Amino-4-carboxy-butyrylamino)-2-(carboxymethyl-carbamoyl)-ethylsulfanyl]-5-hydroxy-icosa-7,9,11,14-tetraenoic acid 
• 79026-72-5 (5R,6S)-LTC₄ 
• 72025-60-6 leukotriene C1 
• 73958-10-8 (7E,9E,11Z,14Z)-(5S,6R)-6-[2-(4-Amino-4-carboxy-butyrylamino)-2-(carboxymethyl-carbamoyl)-ethylsulfanyl]-5-hydroxy-icosa-7,9,11,14-tetraenoic acid methyl ester 
• 72025-60-6 (7E,9E,11Z,14Z)-(5S,6R)-6-[2-(4-Amino-4-carboxy-butyrylamino)-2-(carboxymethyl-carbamoyl)-ethylsulfanyl]-5-hydroxy-icosa-7,9,11,14-tetraenoic acid 
• 73836-78-9 7Z,9E,11E,14Z-LTD₄ 
• 75443-89-9 7Z,9E,11E,14Z-LTE₄ 
• 91944-21-7 7Z,9E,11E,14Z-LTD₄ methyl ester 
• 89461-64-3 7Z,9E,11E,14Z-LTE₄ methyl ester 
• 72025-60-6 5(S)-hydroxy-6(R)-glutathionyl-7,9-E-11,14-Z-eicosatetraenoic acid 
• 72025-60-6 leukotriene C4 
• 72025-60-6 (7E,9Z,11Z,14Z)-(5S,6R)-6-[(S)-2-((S)-4-Amino-4-carboxy-butyrylamino)-2-(carboxymethyl-carbamoyl)-ethylsulfanyl]-5-hydroxy-icosa-7,9,11,14-tetraenoic acid 
• 72025-60-6 (7E,9Z,11Z,14Z)-(5R,6S)-6-[(S)-2-((S)-4-Amino-4-carboxy-butyrylamino)-2-(carboxymethyl-carbamoyl)-ethylsulfanyl]-5-hydroxy-icosa-7,9,11,14-tetraenoic acid 

Relevant articles and documents

AN EFFICIENT AND SIMPLE METHOD THE CONVERSION OF 15-HPETE TO 14,15-EPETE (LIPOTRIENE A) AND 5-HPETE TO LEUKOTRIENE A AS THE METHYL ESTERS

Simple new methodology is described for the synthesis from arachidonic acid of the important eicosanoids lipotriene A methyl ester (5) and leukotriene A methyl ester (10), a key feature being the use of a novel chemical method for effecting the allylic hydroperoxide oxiranyl carbinol rearrangement.

SYNTHESIS OF (+/-)-5,6-EPOXY-7E,9E,11Z,14Z-EICOSATETRAENOIC ACID METHYL ESTER

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A NOVEL STEREOSPECIFIC SYNTHESIS OF (+/-)-LEUKOTRIENE A4(LTA4),METHYL ESTER

The reaction of the phosphonate 1 with the epoxyaldehyde 2 is reported as the key step in a novel stereospecific synthesis of (+/-)-LTA4, methyl ester 3.