72402-14-3

Basic information

• Product Name: Methyl-2,3-O-isopropylidene-D-ribofuranoside
• Synonyms: METHYL 2,3-O-ISOPROPYLIDENE-D-RIBOFURANOSIDE;METHYL 2,3-O-ISOPROPYLIDEN-D-RIBOFURANOSE;METHYL-2,3-O-ISOPROPYLIDENE-ALPHA,BETA-D-RIBOFURANOSIDE;METHYL 2,3-O-ISOPROPYLIDENE-B-D-RIBOFURANOSIDE;[(3aR,4R,6aR)-6-methoxy-2,2-dimethyl-tetrahydro-2H-furo[3,4-d][1,3]dioxol-4-yl]methanol;((3aR,4R,6aR)-6-Methoxy-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-yl)methanol
• CAS NO: 72402-14-3
• Molecular Formula: C₉H₁₆O₅
• Molecular Weight: 204.22
• Mol File: 72402-14-3.mol
• Article Data: 45

Chemical Properties

• Boiling Point: 72-75 °C(Press: 0.6 Torr)
• Appearance: /
• Density: 1.23±0.1 g/cm3(Predicted)
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 14.14±0.10(Predicted)
• CAS DataBase Reference: Methyl-2,3-O-isopropylidene-D-ribofuranoside(CAS DataBase Reference)
• NIST Chemistry Reference: Methyl-2,3-O-isopropylidene-D-ribofuranoside(72402-14-3)
• EPA Substance Registry System: Methyl-2,3-O-isopropylidene-D-ribofuranoside(72402-14-3)

Safety Data

• Hazardous Substances Data: 72402-14-3(Hazardous Substances Data)

Usage

Uses

Methyl 2,3-O-Isopropylidene-D-ribofuranoside can be prepared to use as PRMT5 inhibitors.

Upstream product

• 144732-43-4 (3aR,6R,6aR)-4-Methoxy-2,2-dimethyl-6-trityloxymethyl-tetrahydro-furo[3,4-d][1,3]dioxole 
• 532-20-7 D-Ribose 
• 77-76-9 2,2-dimethoxy-propane 
• 36468-53-8 β-D-ribofuranose 
• 122-51-0 orthoformic acid triethyl ester 
• 67-64-1 acetone 
• 67-56-1 methanol 
• 10257-32-6 D-ribose 
• 50-69-1 D-ribose 
• 1824-96-0 methyl ribofuranoside 

Downstream Products

• 98807-30-8 N⁴-Benzoyl-1-(2,3-O-isopropylidene-α-D-ribofuranosyl)-cytosine 
• 39946-94-6 4-N-benzoyl-2',3'-O-isopropylidenecytidine 
• 72402-15-4 1-O-methyl-5-O-benzyl-2,3-O-isopropylidene-D-ribofuranoside 
• 268545-16-0 5-O-benzoyl-2,3-isopropylidene-1-methoxy-D-ribofuranoside 
• 155934-55-7 (4R,5R)-2,2-dimethyl-5-vinyl-[1,3]dioxolane-4-carbaldehyde 
• 115509-13-2 (3aR,6aR)-2,2-Dimethyl-3a,6a-dihydro-cyclopenta[1,3]dioxol-4-one 
• 595581-64-9 (3aR,6aR)-2,2-dimethyltetrahydro-4H-cyclopenta[d][1,3]dioxol-4-one 
• 404353-62-4 benzyl-(5,6-bis-benzyloxy-4-tert-butoxycarbonylamino-7-hydroxy-heptyl)-carbamic acid tert-butyl ester 
• 602298-21-5 (2R,3R,4R)-2-(3-Azido-propyl)-3,4-bis-benzyloxy-5-methoxy-tetrahydro-furan 
• 602298-23-7 carbonic acid 2,3-bis-benzyloxy-7-tert-butoxycarbonylamino-4-hydroxy-heptyl ester tert-butyl ester 
• 602298-24-8 carbonic acid 4-azido-2,3-bis-benzyloxy-7-tert-butoxycarbonylamino-heptyl ester tert-butyl ester 
• 602298-25-9 ((4S,5R,6S)-4-Azido-5,6-bis-benzyloxy-7-hydroxy-heptyl)-benzyl-carbamic acid tert-butyl ester 
• 156475-03-5 [(2R,3S,4S)-3,4-dihydroxytetrahydro-2-furanyl]methyl benzoate 
• 78341-97-6 1-O-methyl-2,3-O-isopropylidene-5-deoxy-D-ribofuranose 

Relevant articles and documents

MEAYAMYCIN ANALOGUES AND METHODS OF USE

Compounds according to formula (I), where R is as defined herein, have anti-cancer properties.

Preparation method of ticagrelor key intermediate iodide

The invention discloses a preparation method of ticagrelor key intermediate iodide, which comprises the following steps of: (1) synthesis of an intermediate 1: taking D-ribose as a raw material, methanol and acetone as solvents, adding thionyl chloride as a catalyst, and concentrating to remove the solvents after the reaction is finished, so as to obtain the intermediate 1, and (3) synthesis of the key intermediate iodide: by taking acetonitrile as a solvent, adding the intermediate 1 and sodium iodide into a reaction system, dropwise adding trimethylchlorosilane, adding a small amount of water for quenching reaction after the reaction is finished, evaporating to remove acetonitrile, extracting with the solvent, and concentrating to obtain the key intermediate iodide. According to the preparation method of the ticagrelor key intermediate iodide, in the synthesis process of the intermediate 1, thionyl chloride is adopted to replace hydrochloric acid to serve as a catalyst, the reactionconversion rate is greatly increased, then trimethylchlorosilane/sodium iodide serves as an iodinating agent, the reaction condition is mild, aftertreatment is simple, and the conversion rate is high.

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