72620-07-6Relevant articles and documents
anti-inflammntory phamaceutical composition containing a novel acetylated flavonoid-type compound showing anti-inflammatory activity and method for synthesizing thereof
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Paragraph 0166; 0167; 0168; 0169; 0170; 0171, (2017/10/20)
Gossypetin is a natural compound derived from a calyx of Hibiscus sabdariffa. According to the present invention, after raw 264.7 cells are treated with a compound represented by a chemical formula 1, an immunological activity of the cells was analyzed and compared. As a result, the expression of NLRP3 and NF-kB, which activate an inflammatory pathway, was confirmed to be significantly inhibited from the raw 264.7 cells treated with a novel flavonoid-based compound in accordance with the present invention. The results found that the novel flavonoid-based compound in accordance with the present invention inhibited an inflammatory mediator and inflammasome in macrophages and suppressed the secretion of TNF-andalpha; and IL-1andbeta; associated therewith. Therefore, as in an experimental example of the present invention, the novel flavonoid-based compound in accordance with the present invention has been confirmed to have an anti-inflammatory effect superior to that of a conventional gossypetin compound in the expression of an inflammatory disease in cells in which an inflammation activity is induced by treatment with LPS.COPYRIGHT KIPO 2017
FLAVONOIDS FROM ARTEMISIA LANATA
a D.,Collado, I. Gonzales,Macias, F. A.,Massanet, G. M.,Luis, Rodriguez F.
, p. 1502 - 1504 (2007/10/02)
A new flavonoid, gossypetin-7,8,3',4'-tetramethyl ether (3,5-dihydroxy-7,8,3',4'-tetramethoxyflavone) was isolated and its structure elucidated by chemical and spectroscopic methods.The known flavonoids 5-hydroxy-6,7,3',4'-tetramethoxyflavone and artemeti
