72653-14-6

Basic information

• Product Name: 4-ACETYL-4-(ETHOXYCARBONYL)HEPTANEDIOIC ACID
• Synonyms: 4-ACETYL-4-(ETHOXYCARBONYL)HEPTANEDIOIC ACID;ETHYL 2,2-BIS(2-CARBOXYETHYL)ACETOACETATE;4-Acetyl-4-(ethoxycarbonyl)heptane-1,7-dioic acid;4-Acetyl-4-(ethoxycarbonyl)pimelic acid, 3-Acetyl-3-(ethoxycarbonyl)pentane-1,5-dicarboxylic acid, Ethyl 2,2-bis(2-carboxyethyl)acetoacetate;4-Acetyl-4-(ethoxycarbonyl)
• CAS NO: 72653-14-6
• Molecular Formula: C₁₂H₁₈O₇
• Molecular Weight: 274.27
• Mol File: 72653-14-6.mol
• Article Data: 3

Chemical Properties

• Melting Point: 105 °C
• Boiling Point: 504.5 °C at 760 mmHg
• Flash Point: 191.1 °C
• Appearance: /
• Density: 1.266 g/cm³
• Vapor Pressure: 1.52E-11mmHg at 25°C
• Refractive Index: 1.489
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 4-ACETYL-4-(ETHOXYCARBONYL)HEPTANEDIOIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 4-ACETYL-4-(ETHOXYCARBONYL)HEPTANEDIOIC ACID(72653-14-6)
• EPA Substance Registry System: 4-ACETYL-4-(ETHOXYCARBONYL)HEPTANEDIOIC ACID(72653-14-6)

Safety Data

• Hazard Codes: Xi:Irritant
• Statements: R36/37/38:Irritating to eyes, respiratory system and skin.
• Safety Statements: S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.; S37/39:Wear suitable g
• Hazardous Substances Data: 72653-14-6(Hazardous Substances Data)

Usage

General Description

4-ACETYL-4-(ETHOXYCARBONYL)HEPTANEDIOIC ACID, also known as Tranexamic Acid, is a synthetic derivative of the amino acid lysine. It is widely used as a medication to treat excessive bleeding during surgeries, heavy menstrual bleeding, and other medical conditions. The compound works by inhibiting the breakdown of blood clots, thereby reducing the risk of excessive bleeding. Additionally, 4-ACETYL-4-(ETHOXYCARBONYL)HEPTANEDIOIC ACID has also been studied for its potential in treating skin hyperpigmentation, as it can inhibit melanin production. The compound is typically administered orally, topically, or through injection under medical supervision. Overall, 4-ACETYL-4-(ETHOXYCARBONYL)HEPTANEDIOIC ACID plays a crucial role in managing bleeding disorders and may hold promise for other therapeutic applications.

InChI:InChI=1/C12H18O7/c1-3-19-11(18)12(8(2)13,6-4-9(14)15)7-5-10(16)17/h3-7H2,1-2H3,(H,14,15)(H,16,17)

Upstream product

• 141-97-9 ethyl acetoacetate 
• 1135619-58-7 1,5-di-tert-butyl 3-ethyl 3-acetylpentane-1,3,5-tricarboxylate 
• 72948-75-5 tris-ethyl 3-acetylpentane-1,3,5-tricarboxylate 
• 1112-25-0 2,2-bis-(2-cyano-ethyl)-acetoacetic acid ethyl ester 

Downstream Products

• 72653-21-5 ethyl 1-acetyl-4-oxocyclohexane-1-carboxylate 
• 1207166-75-3 ethyl 4-(benzylamino)-2-oxobicyclo[2.2.2]octane-1-carboxylate 
• 1207166-77-5 ethyl 4-(benzylamino)-2-hydroxybicyclo[2.2.2]octane-1-carboxylate 
• 1207166-78-6 ethyl 4-(benzylamino)-2-((methylsulfonyl)oxy)bicyclo[2.2.2]octane-1-carboxylate 
• 1207166-79-7 ethyl 4-(benzylamino)bicyclo[2.2.2]oct-2-ene-1-carboxylate 
• 135908-45-1 ethyl 4-aminobicyclo[2.2.2]octane-1-carboxylate 
• 72948-89-1 4-(hydroxymethyl)bicyclo[2.2.2]octan-1-ol 
• 1127-13-5 4-hydroxybicyclo[2.2.2]octane-1-carboxylic acid 
• 72948-78-8 ethyl 4-hydroxybicyclo[2.2.2]octane-1-carboxylate 
• 78385-84-9 4-fluorobicyclo<2.2.2>octane-1-carboxylic acid 
• 78385-91-8 amino-4-fluorobicyclo[2.2.2]octane 
• 81687-78-7 4-Fluoro-bicyclo[2.2.2]octane-1-carbonyl chloride 
• 23062-53-5 methyl 4-hydroxybicyclo<2.2.2>octane-1-carboxylate 
• 773-34-2 4-methoxybicyclo<2.2.2>octane-1-carboxylic acid 

Relevant articles and documents

A Molecular Torsion Balance Study: A Nearby Anionic Group Exerts Little Influence on Hydrophobic Interactions between Nonpolar Surfaces

Polar groups have a solvent ordering effect on water and therefore may affect hydrophobic binding energies for nearby lipophilic surfaces. This would mean that determinations of excess surface free energy association energies require consideration of nearby polar functional groups. This paper reports results of a study to measure this possible effect. It was concluded from the models used here that an anionic polar group nearby a hydrophobic surface has little or no effect on the magnitude of hydrophobic association.

PYRIMIDO- [4, 5-B] -OXAZINES FOR USE AS DGAT INHIBITORS

Formula (I). Compounds of formula (I) or salts thereof, wherein A1, and R1 to R5 are as defined in the specification, are DGAT-1 inhibitors and are thereby useful in the treatment of, for example, obesity. Processes to make compounds of formula (I) are also described.