72948-89-1

Basic information

• Product Name: 4-(hydroxyMethyl)bicyclo[2.2.2]octan-1-ol
• Synonyms: 4-(hydroxyMethyl)bicyclo[2.2.2]octan-1-ol
• CAS NO: 72948-89-1
• Molecular Formula: C₉H₁₆O₂
• Molecular Weight: 156.22214
• Mol File: 72948-89-1.mol
• Article Data: 1

Chemical Properties

• Melting Point: 133.5-135.0 °C
• Boiling Point: 268.0±8.0 °C(Predicted)
• Appearance: /
• Density: 1.220±0.06 g/cm3(Predicted)
• PKA: 15.18±0.40(Predicted)
• CAS DataBase Reference: 4-(hydroxyMethyl)bicyclo[2.2.2]octan-1-ol(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(hydroxyMethyl)bicyclo[2.2.2]octan-1-ol(72948-89-1)
• EPA Substance Registry System: 4-(hydroxyMethyl)bicyclo[2.2.2]octan-1-ol(72948-89-1)

Safety Data

• Hazardous Substances Data: 72948-89-1(Hazardous Substances Data)

Usage

Description

4-(HydroxyMethyl)bicyclo[2.2.2]octan-1-ol, also known as Glycerol, is a simple polyol compound with a hydroxyl group attached to a bicyclic structure. It is a colorless, viscous liquid that is hygroscopic in nature. Glycerol is widely used in various industries due to its unique properties and versatile applications.

Uses

Used in Pharmaceutical Industry:
4-(HydroxyMethyl)bicyclo[2.2.2]octan-1-ol is used as a key intermediate compound for the preparation of orally bioavailable TLR7/8 antagonists. These antagonists play a crucial role in modulating the immune response and have potential applications in the treatment of various autoimmune diseases and conditions related to an overactive immune system.
Used in Cosmetics and Personal Care Industry:
Glycerol is used as a humectant, moisturizer, and emollient in the cosmetics and personal care industry. Its ability to attract and retain moisture makes it an essential ingredient in various skincare products, such as lotions, creams, and shampoos, to maintain skin hydration and suppleness.
Used in Food and Beverage Industry:
In the food and beverage industry, glycerol is used as a sweetener, humectant, and preservative. It helps to retain moisture in foods, preventing them from drying out and extending their shelf life. Additionally, it is used in the production of e-liquids for electronic cigarettes, providing a smooth and pleasant vaping experience.
Used in Industrial Applications:
Glycerol is utilized as a raw material in the manufacturing of various chemicals, such as glycerol esters, polyglycerols, and glycerol ethers. These derivatives find applications in the production of resins, plastics, and other industrial products.
Used in Energy Industry:
Glycerol can be used as a feedstock for the production of biofuels, such as biodiesel and bioalcohols. Its conversion into biofuels offers a sustainable and environmentally friendly alternative to fossil fuels.

Upstream product

• 72653-14-6 1,5-di-tert-butyl 3-ethyl 3-acetylpentane-1,3,5-tricarboxylate 
• 72948-75-5 tris-ethyl 3-acetylpentane-1,3,5-tricarboxylate 
• 72948-76-6 ethyl 4-hydroxy-2-oxobicyclo[2.2.2]octane-1-carboxylate 
• 72653-21-5 ethyl 1-acetyl-4-oxocyclohexane-1-carboxylate 
• 72948-77-7 ethyl 4-hydroxyspiro[bicyclo[2.2.2]octane-2,2'-[1,3]dithiolane]-1-carboxylate 
• 72948-78-8 ethyl 4-hydroxybicyclo[2.2.2]octane-1-carboxylate 

Relevant articles and documents

A Molecular Torsion Balance Study: A Nearby Anionic Group Exerts Little Influence on Hydrophobic Interactions between Nonpolar Surfaces

Polar groups have a solvent ordering effect on water and therefore may affect hydrophobic binding energies for nearby lipophilic surfaces. This would mean that determinations of excess surface free energy association energies require consideration of nearby polar functional groups. This paper reports results of a study to measure this possible effect. It was concluded from the models used here that an anionic polar group nearby a hydrophobic surface has little or no effect on the magnitude of hydrophobic association.