72724-00-6

Basic information

• Product Name: 1-(benzyloxy)-4-(broMoMethyl)-2-Methoxybenzene
• Synonyms: 1-(benzyloxy)-4-(broMoMethyl)-2-Methoxybenzene
• CAS NO: 72724-00-6
• Molecular Formula: C₁₅H₁₅BrO₂
• Molecular Weight: 307.1824
• Mol File: 72724-00-6.mol
• Article Data: 27

Chemical Properties

• Boiling Point: 390.7°Cat760mmHg
• Flash Point: 167.6°C
• Appearance: /
• Density: 1.349g/cm³
• Vapor Pressure: 5.86E-06mmHg at 25°C
• Refractive Index: 1.589
• CAS DataBase Reference: 1-(benzyloxy)-4-(broMoMethyl)-2-Methoxybenzene(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(benzyloxy)-4-(broMoMethyl)-2-Methoxybenzene(72724-00-6)
• EPA Substance Registry System: 1-(benzyloxy)-4-(broMoMethyl)-2-Methoxybenzene(72724-00-6)

Safety Data

• Hazardous Substances Data: 72724-00-6(Hazardous Substances Data)

Usage

Chemical structure

Substituted benzene derivative
The compound is derived from benzene, a basic aromatic ring structure, with additional functional groups attached.

Functional groups

Benzyl ether and bromomethyl groups
The compound contains a benzyl ether group (C6H5-CH2-O-) and a bromomethyl group (-CH2Br) attached to the benzene ring.

Synonyms

4-(bromomethyl)-1-benzyloxy-2-methoxybenzene
The compound is also known by this alternative name, which highlights the positions of the functional groups on the benzene ring.

Applications

Organic synthesis and pharmaceutical research
The compound is commonly used in the synthesis of more complex organic compounds and is also utilized in the development of drug candidates.

Potential uses

Development of drug candidates and production of fine chemicals
Due to its unique structure and functional groups, the compound has potential applications in the pharmaceutical industry and the production of specialty chemicals.

Versatility

Building block for complex compound synthesis
The compound's structure and functional groups make it a valuable starting material for the synthesis of more complex organic molecules.

InChI:InChI=1/C15H15BrO2/c1-17-15-9-13(10-16)7-8-14(15)18-11-12-5-3-2-4-6-12/h2-9H,10-11H2,1H3

Upstream product

• 100-44-7 benzyl chloride 
• 121-33-5 vanillin 
• 498-00-0 4-hydroxymethyl-2-methoxyphenol 
• 100-39-0 benzyl bromide 
• 2426-87-1 3-methoxy-4-(phenylmethoxy)benzaldehyde 
• 33693-48-0 4-benzyloxy-3-methoxybenzyl alcohol 

Downstream Products

• 84755-36-2 2-(4-benzyloxy-3-methyoxybenzyl)-3-(3,4-methylenedioxybenzyl)-γ-butyrolactone 
• 1700-29-4 2-(4-(benzyloxy)-3-methoxyphenyl)acetonitrile 
• 111194-07-1 (3R,4R)-3,4-bis(4-benzyloxy-3-methoxybenzyl)dihydrofuran-2(3H)-one 
• 124988-59-6 (3S,4S)-3,4-bis(4-benzyloxy-3-methoxybenzyl)dihydrofuran-2(3H)-one 
• 60136-26-7 4-Benzyloxy-3-methoxyphenyl<1-¹⁴C>acetonitril 
• 123251-05-8 (3R,4R)-3-[(3-methoxy-4-benzyloxyphenyl)methyl]-4-[(3,4-dimethoxyphenyl)methyl] dihydro-2-(3H)-furanone 
• 127951-04-6 (+/-)-2-(4-Benzyloxy-3-methoxybenzyl)-3-(α-benzyloxy-4-hydroxy-3-methoxybenzyl)butan-4-olide 
• 127951-04-6 4-[Benzyloxy-(4-hydroxy-3-methoxy-phenyl)-methyl]-3-(4-benzyloxy-3-methoxy-benzyl)-dihydro-furan-2-one 
• 127951-04-6 (2R,3R)-(6R,S)-(+)-2-(4-Benzyloxy-3-methoxybenzyl)-3-(α-benzyloxy-4-hydroxy-3-methoxybenzyl)butan-4-olide 
• 89067-57-2 (benzoxy-4 methoxy-3)benzyl-2(benzoxy-4 methoxy-3 α,α-propylenedithio)benzyl-3 butanolide 
• 123251-05-8 trans-α-(3-methoxy-4-benzyloxybenzyl)-β-(3,4-dimethoxybenzyl)-γ-butyrolactone 

Relevant articles and documents

Application of gastrodia elata bl derived derivative to preparation of medicine for treating acute or chronic pain

The invention discloses application of gastrodia elata bl derived derivatives to preparation of a medicine for treating the acute or chronic pain, in particular to compounds as shown in general formulas (I), (II) and (III) and application of pharmaceutically acceptable salt thereof to preparation of the medicine for preventing and/or treating the acute or chronic pain, discloses a preparation method of the compounds, and belongs to the technical field of medicine.

Synthesis and pharmacological characterisation of arctigenin analogues as antagonists of AMPA and kainate receptors

(-)-Arctigenin and a series of new analogues have been synthesised and then tested for their potential as AMPA and kainate receptor antagonists of human homomeric GluA1 and GluK2 receptors expressed in HEK293 cells using a Ca2+ influx assay. In general, these compounds showed antagonist activity at both receptors with greater activity evident at AMPARs. Schild analysis indicates that a spirocyclic analogue 6c acts as a non-competitive antagonist. Molecular docking studies in which 6c was docked into the X-ray crystal structure of the GluA2 tetramer suggest that (-)-arctigenin and its analogues bind in the transmembrane domain in a similar manner to the known AMPA receptor non-competitive antagonists GYKI53655 and the antiepileptic drug perampanel. The arctigenin derivatives described herein may serve as novel leads for the development of drugs for the treatment of epilepsy. This journal is

Synthesis of phenolic components of Grains of Paradise

Two vanilloids, (5E)-8-(4-hydroxy-3-methoxyphenyl)oct-5-en-4-one (1) and 4-[3-hydroxydecyl]-2-methoxyphenol (2), isolated from the dried seeds of Grains of Paradise (Aframomum melegueta), were synthesized; the latter compound was made as the S-enantiomer and the material derived from the seeds was found to be a 1:1.7 mixture of the R and S isomers. The synthetic route used should allow the preparation of analogs having extended alkyl chains and consequently different lipophilicity, and 3, a homolog of 2, was also prepared.