7283-64-9

Basic information

• Product Name: dibenzyl vinylphosphonate
• Synonyms: dibenzyl vinylphosphonate
• CAS NO: 7283-64-9
• Molecular Weight: 288.283
• Mol File: 7283-64-9.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: dibenzyl vinylphosphonate(CAS DataBase Reference)
• NIST Chemistry Reference: dibenzyl vinylphosphonate(7283-64-9)
• EPA Substance Registry System: dibenzyl vinylphosphonate(7283-64-9)

Safety Data

• Hazardous Substances Data: 7283-64-9(Hazardous Substances Data)

Upstream product

• 1438-74-0 vinyldichlorophosphine oxide 
• 100-51-6 benzyl alcohol 

Downstream Products

• 99322-48-2 dibenzyl 4,5,6-tri-O-benzyl-8-O-(dibenzyloxyphosphoryl)-1,2,3-trideoxy-3-nitro-α-D-altro-3-octulopyranose-1-phosphonate 
• 99322-49-3 dibenzyl 4,5,6-tri-O-benzyl-8-O-(dibenzyloxyphosphoryl)-1,2-dideoxy-D-altro-3-octulopyranose-1-phosphonate 
• 1746-03-8 vinylphosphonic acid 
• 99322-47-1 dibenzyl 4,5,6-tri-O-benzyl-1,2,3-trideoxy-3-nitro-α-D-altro-octulopyranose-1-phosphonate 

Relevant articles and documents

Zwitterionic pyrrolidene-phosphonates: Inhibitors of the glycoside hydrolase-like phosphorylase: Streptomyces coelicolor GlgEI-V279S

We synthesized and evaluated new zwitterionic inhibitors against glycoside hydrolase-like phosphorylase Streptomyces coelicolor (Sco) GlgEI-V279S which plays a role in α-glucan biosynthesis. Sco GlgEI-V279S serves as a model enzyme for validated anti-Tuberculosis (TB) target Mycobacterium tuberculosis (Mtb) GlgE. Pyrrolidine inhibitors 5 and 6 were designed based on transition state considerations and incorporate a phosphonate on the pyrrolidine moiety to expand the interaction network between the inhibitor and the enzyme active site. Compounds 5 and 6 inhibited Sco GlgEI-V279S with Ki = 45 ± 4 μM and 95 ± 16 μM, respectively, and crystal structures of Sco GlgE-V279S-5 and Sco GlgE-V279S-6 were obtained at a 3.2 ? and 2.5 ? resolution, respectively.

89. Deoxy-nitrosugars. 10th Communication. Synthesis of Isosteric Phosphonate Analogues of Ulose-1-Phosphates

A general approach to isosteric phosphonate analogues of ulose-1-phosphates is described.A base-catalysed chain elongation via a Michael addition of 1-deoxy-1-nitro-sugars 4, 8, and 16 to the vinylphosphonate 18 followed by hydrolysis of the nitro adducts