72857-85-3

Basic information

• Product Name: 3,4-DICHLORO-5-PHENYL-2(5H)-FURANONE
• Synonyms: 3,4-DICHLORO-5-PHENYL-2(5H)-FURANONE
• CAS NO: 72857-85-3
• Molecular Formula: C₁₀H₆Cl₂O₂
• Molecular Weight: 229.06
• Mol File: 72857-85-3.mol
• Article Data: 12

Chemical Properties

• Melting Point: 80 °C(Solv: methanol (67-56-1))
• Boiling Point: 373.6±42.0 °C(Predicted)
• Appearance: /
• Density: 1.45±0.1 g/cm3(Predicted)
• CAS DataBase Reference: 3,4-DICHLORO-5-PHENYL-2(5H)-FURANONE(CAS DataBase Reference)
• NIST Chemistry Reference: 3,4-DICHLORO-5-PHENYL-2(5H)-FURANONE(72857-85-3)
• EPA Substance Registry System: 3,4-DICHLORO-5-PHENYL-2(5H)-FURANONE(72857-85-3)

Safety Data

• Hazardous Substances Data: 72857-85-3(Hazardous Substances Data)

Upstream product

• 766-40-5 Mucochloric acid 
• 71-43-2 benzene 
• 57697-64-0 mucochloric acid 
• 87-56-9 mucochloric acid 

Downstream Products

• 67052-07-7 (Z)-2,3-Dichloro-4-phenyl-4-p-tolyl-but-2-enoic acid 
• 87769-63-9 5-amino-6-phenyl-1,6-dihydropyridazin-3(2H)-one 
• 23066-93-5 3,4-dichloro-5-methoxy-2-(5H)furanone 
• 1610354-27-2 1-((3S,4R)-4-(3,4-difluorophenyl)-1-(2-methoxyethyl)pyrrolidin-3-yl)-3-(6-oxo-3-phenyl-1-(2,2,2-trifluoroethyl)-1,6-dihydropyridazin-4-yl)urea 
• 1610354-26-1 1-((3S,4R)-4-(3,4-difluorophenyl)-1-(2-methoxyethyl)pyrrolidin-3-yl)-3-(1-methyl-6-oxo-3-phenyl-1,6-dihydropyridazin-4-yl)urea 
• 1610354-61-4 5-amino-6-phenyl-2-(2,2,2-trifluoroethyl)pyridazin-3(2H)-one 
• 1610354-60-3 5-azido-6-phenyl-2-(2,2,2-trifluoroethyl)pyridazin-3(2H)-one 
• 1610354-59-0 phenyl 1-methyl-6-oxo-3-phenyl-1,6-dihydropyridazin-4-ylcarbamate 
• 126336-94-5 5-amino-2-methyl-6-phenylpyridazin-3(2H)-one 
• 126337-06-2 5-azido-2-methyl-6-phenylpyridazin-3(2H)-one 
• 132814-13-2 6-phenyl-5-(N⁴-(2-furoyl)-N¹-piperazinyl)-2H-pyridazin-3-one 
• 132814-12-1 6-phenyl-5-(N⁴-benzoyl-N¹-piperazinyl)-2H-pyridazin-3-one 
• 132814-16-5 6-phenyl-5-(N¹-piperazinyl)-2H-pyridazin-3-one 
• 33389-38-7 5-chloro-2-methyl-6-phenylpyridazin-3(2H)-one 

Relevant articles and documents

N-substituted 5-chloro-6-phenylpyridazin-3(2H)-ones: Synthesis, insecticidal activity against Plutella xylostella (L.) and SAR study

A series of N-substituted 5-chloro-6-phenylpyridazin-3(2H)-one derivatives were synthesized based on our previous work; all compounds were characterized by spectral data and tested for in vitro insecticidal activity against Plutella xylostella. The result

Design, synthesis, and In vitro antituberculosis activity of 2(5H)-Furanone derivatives

A series of 2(5H)-furanone-based compounds were synthesized from commercially available mucohalic acids. From the first-generation compounds, three showed inhibitory activity (10 μg/mL) of at least 35% against Mycobacterium smegmatis mc2 155 growth (Bioscreen C system). In screening the active first-generation compounds for growth inhibition against Mycobacterium tuberculosis H37Rv, the most active compound was identified with a minimum inhibitory concentration (MIC99) of 8.07 μg/mL (15.8 μM) using BACTEC 460 system. No cross-resistance was observed with some current first-line anti-TB drugs, since it similarly inhibited the growth of multidrug resistant (MDR) clinical isolates. The compound showed a good selectivity for mycobacteria since it did not inhibit the growth of selected Gram-positive and Gram-negative bacteria. It also showed synergistic activity with rifampicin (RIF) and additive activity with isoniazid (INH) and ethambutol (EMB). Additional time-kill studies showed that the compound is bacteriostatic to mycobacteria, but cytotoxic to the Chinese Hamster Ovarian (CHO) cell line. From a second generation library, two compounds showed improved anti-TB activity against M. tuberculosis H37Rv and decreased CHO cell cytotoxicity. The compounds exhibited MIC values of 2.62 μg/mL (5.6 μM) and 3.07 μg/mL (5.6 μM) respectively. The improved cytotoxicity against CHO cell line of the two compounds ranged from IC50 = 38.24 μg/mL to IC50 = 45.58 μg/mL when compared to the most active first-generation compound (IC50 = 1.82 μg/mL). The two second generation leads with selectivity indices (SI) of 14.64 and 14.85 respectively, warrant further development as anti-TB drug candidates.

COMPOSITIONS AND METHODS FOR VIRAL SENSITIZATION

Provided are compounds that enhance the efficacy of viruses by increasing spread of the virus in cells, increasing the titer of virus in cells, or increasing the antigen expression from a virus, gene or trans-gene expression from a virus, or virus protein expression in cells. Other uses, compositions and methods of using same are also provided.