23066-93-5

Basic information

• Product Name: 3,4-dichloro-5-methoxyfuran-2(5H)-one
• CAS NO: 23066-93-5
• Molecular Formula: C₅H₄Cl₂O₃
• Molecular Weight: 182.9895
• Mol File: 23066-93-5.mol
• Article Data: 8

Chemical Properties

• Boiling Point: 271°C at 760 mmHg
• Flash Point: 128.3°C
• Density: 1.53g/cm³
• Vapor Pressure: 0.00663mmHg at 25°C
• Refractive Index: 1.511
• CAS DataBase Reference: 3,4-dichloro-5-methoxyfuran-2(5H)-one(CAS DataBase Reference)
• NIST Chemistry Reference: 3,4-dichloro-5-methoxyfuran-2(5H)-one(23066-93-5)
• EPA Substance Registry System: 3,4-dichloro-5-methoxyfuran-2(5H)-one(23066-93-5)

Safety Data

• Hazardous Substances Data: 23066-93-5(Hazardous Substances Data)

Upstream product

• 67-56-1 methanol 
• 72857-85-3 α,β-dichloro-γ-phenyl-Δ^α,β-crotonolactone 
• 766-40-5 Mucochloric acid 
• 87-56-9 mucochloric acid 

Relevant articles and documents

Simple 2(5H)-furanone derivatives with selective cytotoxicity towards non-small cell lung cancer cell line A549 – Synthesis, structure-activity relationship and biological evaluation

A series of 5-alkoxy derivatives of 3,4-dichloro-5-hydroxyfuran-2-(5H)-one (mucochloric acid, MCA) were obtained and subsequently subjected to modification in the C-4 position of 2(5H)-furanone ring. The cytotoxicity of newly synthesized compounds was evaluated in MTT assay against non-small cell lung cancer (A549) and healthy lung epithelial cell line (BEAS-2B). The derivatives containing a branched alkoxy substituent in the C-5 position demonstrated the highest anticancer properties, whereas modification of compounds in the C-4 position of 2(5H)-furanone ring only slightly improve their antiproliferative properties. Compounds 12 and 15 exhibited the best selectivity towards A549 cells and were also evaluated in a panel of cancer cell lines of different origin. Further investigation revealed that treatment of A549 cell line with compounds 12 and 15 led to G2 phase cell cycle arrest and induction of caspase-independent cell death. Moreover, compound 12 was found to act synergistically with erlotinib.

Synthesis and biological evaluation of novel artemisone-piperazine-tetronamide hybrids

For the first time, six novel artemisone-piperazine-tetronamide hybrids (12a-f) were efficiently synthesised from dihydroartemisinin (DHA) and investigated for their in vitro cytotoxicity against some human cancer cells and benign cells. All the targets s

Preparation and use of halobutenolide-like compound having insecticidal activity

The invention discloses preparation and use of a halobutenolide-like compound having insecticidal activity. The invention relates to a nitrogen-containing ring-opening compound having a formula (A) where R1, R2, R3 and X are each as defined in the specification. The invention discloses a preparation method of a novel insecticide and the use thereof. The compound and a derivative thereof are used for agricultural and forestry pests with high insecticidal activity such as homoptera and lepidoptera: aphids, planthoppers, whiteflies, leafhoppers, thrips, cotton bollworm, cabbage caterpillar, plutella xylostella, prodenia litura, and armyworm.