73004-96-3 Usage
Description
(3-(2-CHLOROETHYL)PHENYL)METHANOL, with the molecular formula C9H11ClO, is a white to off-white solid chemical compound. It exhibits slight solubility in water and is soluble in organic solvents. (3-(2-CHLOROETHYL)PHENYL)METHANOL is utilized in various applications, primarily in the pharmaceutical industry and as an intermediate in the synthesis of other organic compounds.
Uses
Used in Pharmaceutical Industry:
(3-(2-CHLOROETHYL)PHENYL)METHANOL is used as a key intermediate in the production of pharmaceuticals, playing a crucial role in the synthesis of various medicinal compounds.
Used in Organic Synthesis:
(3-(2-CHLOROETHYL)PHENYL)METHANOL serves as a building block for organic synthesis, contributing to the creation of a wide range of organic compounds.
Used as a Reagent:
(3-(2-CHLOROETHYL)PHENYL)METHANOL is also employed as a reagent in chemical reactions, facilitating specific transformations and processes in the laboratory.
Safety Measures:
It is essential to handle (3-(2-CHLOROETHYL)PHENYL)METHANOL with care due to its moderately hazardous nature. Potential health effects include irritation to the skin, eyes, and respiratory system, along with possible long-term health impacts from prolonged or repeated exposure. Appropriate safety measures should be implemented during its use and handling.
Check Digit Verification of cas no
The CAS Registry Mumber 73004-96-3 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 7,3,0,0 and 4 respectively; the second part has 2 digits, 9 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 73004-96:
(7*7)+(6*3)+(5*0)+(4*0)+(3*4)+(2*9)+(1*6)=103
103 % 10 = 3
So 73004-96-3 is a valid CAS Registry Number.
InChI:InChI=1/C9H11ClO/c1-11-9-4-2-3-8(7-9)5-6-10/h2-4,7H,5-6H2,1H3
73004-96-3Relevant articles and documents
Discovery and stereoselective synthesis of the novel isochroman neurokinin-1 receptor antagonist 'CJ-17,493'
Shishido, Yuji,Wakabayashi, Hiroaki,Koike, Hiroki,Ueno, Naomi,Nukui, Seiji,Yamagishi, Tatsuya,Murata, Yoshinori,Naganeo, Fumiharu,Mizutani, Mayumi,Shimada, Kaoru,Fujiwara, Yoshiko,Sakakibara, Ayano,Suga, Osamu,Kusano, Rinko,Ueda, Satoko,Kanai, Yoshihito,Tsuchiya, Megumi,Satake, Kunio
, p. 7193 - 7205 (2008/12/22)
A novel central nervous system (CNS) selective neurokinin-1 (NK1) receptor antagonist, (2S,3S)-3-[(1R)-6-methoxy-1-methyl-1-trifluoromethylisochroman-7-yl]-methylamino-2-phenylpiperidine 'CJ-17,493' (compound (+)-1), was synthesized stereoselectively using a kinetic resolution by lipase-PS as a key step. Compound (+)-1 displayed high and selective affinity (Ki = 0.2 nM) for the human NK1 receptor in IM-9 cells, potent activity in the [Sar9, Met(O2)11]SP-induced gerbil tapping model (ED50 = 0.04 mg/kg, sc) and in the ferret cisplatin (10 mg/kg, ip)-induced anti-emetic activity model (vomiting: ED90 = 0.07 mg/kg, sc), all levels of activity comparable with those of CP-122,721. In addition, compound (+)-1 exhibited linear pharmacokinetics rather than the super dose-proportionality of CP-122,721 and this result provides a potential solution for the clinical issue observed with CP-122,721.
