73130-07-1

Basic information

• Product Name: 1-ethyl-3-phenyl-1H-pyrazole
• Synonyms: 1-ethyl-3-phenyl-1H-pyrazole
• CAS NO: 73130-07-1
• Molecular Weight: 172.23
• Mol File: 73130-07-1.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: 1-ethyl-3-phenyl-1H-pyrazole(CAS DataBase Reference)
• NIST Chemistry Reference: 1-ethyl-3-phenyl-1H-pyrazole(73130-07-1)
• EPA Substance Registry System: 1-ethyl-3-phenyl-1H-pyrazole(73130-07-1)

Safety Data

• Hazardous Substances Data: 73130-07-1(Hazardous Substances Data)

Upstream product

• 75-03-6 ethyl iodide 
• 2458-26-6 5-phenyl-1H-pyrazole 
• 5226-49-3 N-ethylsydnone 
• 536-74-3 phenylacetylene 
• 104-55-2 3-phenyl-propenal 
• 7318-33-4 cinnamaldehyde tosylhydrazone 
• 6629-60-3 ethylhydrazine oxalic acid salt 

Relevant articles and documents

Palladium-Catalyzed Pyrazole-Directed sp3 C?H Bond Arylation for the Synthesis of β-Phenethylamines

We have developed a method for palladium-catalyzed, pyrazole-directed sp3 C?H bond arylation by aryl iodides. The reaction employs a Pd(OAc)2 catalyst at 5–10 mol % loading and silver(I) oxide as a halide-removal agent, and it proceeds in acetic acid or acetic acid/hexafluoroisopropanol solvent. Ozonolysis of the pyrazole moiety affords pharmaceutically important β-phenethylamines.

Efficient one-pot synthesis of substituted pyrazoles

An efficient, one-pot synthesis of substituted pyrazoles from enones, hydrazides, and halides was developed. In comparison with the classical Knorr pyrazole synthesis, this methodology gave a different type of product (R 3≥R5). A range of substituted pyrazoles were prepared in good to high yields with complete regioselectivity.