7318-33-4

Basic information

• Product Name: N'-(3-Phenyl-2-propenylidene)-p-toluenesulfonic acid hydrazide
• Synonyms: 3-Phenylacrylaldehyde tosylhydrazone;3-Phenylpropenal [(4-methylphenyl)sulfonyl]hydrazone;Cinnamaldehyde tosylhydrazone;N'-(3-Phenyl-2-propenylidene)-p-toluenesulfonic acid hydrazide;N2-(3-Phenyl-2-propen-1-ylidene)-4-methylbenzenesulfonohydrazide
• CAS NO: 7318-33-4
• Molecular Formula: C₁₆H₁₆N₂O₂S
• Molecular Weight: 300.3754
• Mol File: 7318-33-4.mol
• Article Data: 21

Chemical Properties

• Boiling Point: 470.6°Cat760mmHg
• Flash Point: 238.4°C
• Appearance: /
• Density: 1.14g/cm³
• CAS DataBase Reference: N'-(3-Phenyl-2-propenylidene)-p-toluenesulfonic acid hydrazide(CAS DataBase Reference)
• NIST Chemistry Reference: N'-(3-Phenyl-2-propenylidene)-p-toluenesulfonic acid hydrazide(7318-33-4)
• EPA Substance Registry System: N'-(3-Phenyl-2-propenylidene)-p-toluenesulfonic acid hydrazide(7318-33-4)

Safety Data

• Hazardous Substances Data: 7318-33-4(Hazardous Substances Data)

Upstream product

• 100-52-7 benzaldehyde 
• 104-55-2 3-phenyl-propenal 
• 1576-35-8 toluene-4-sulfonic acid hydrazide 
• 14371-10-9 (E)-3-phenylpropenal 
• 70-55-3 toluene-4-sulfonamide 

Downstream Products

• 14371-10-9 (E)-3-phenylpropenal 
• 637-50-3 1-phenylpropene 
• 16215-11-5 trans-cinnamyl p-tolyl sulfone 
• 1033053-73-4 C₁₉H₁₈N₂O₂S 
• 1380100-08-2 1-benzyl-2-((1Z,3E)-4-phenylbuta-1,3-dien-1-yl)pyrrolidine 
• 1380100-07-1 1-benzyl-2-((1E,3E)-4-phenylbuta-1,3-dien-1-yl)pyrrolidine 
• 52378-69-5 diethyl cinnamylphosphonate 
• 7188-90-1 1-benzyl-3-phenyl-1H-pyrazole 
• 126382-89-6 phenyl(3-phenyl-1H-pyrazol-1-yl)methanone 
• 73130-07-1 1-ethyl-3-phenyl-1H-pyrazole 
• 57443-66-0 1-allyl-3-phenyl-1H-pyrazole 
• 1385068-82-5 3-phenyl-1-(prop-2-yn-1-yl)-1H-pyrazole 
• 1470025-57-0 (E)-dimethyl 5-methyl-1-styryl-1H-indene-2,2(3H)-dicarboxylate 
• 1470025-58-1 (E)-dimethyl 5-fluoro-1-styryl-1H-indene-2,2(3H)-dicarboxylate 

Relevant articles and documents

Diversity-Oriented Synthesis of 1,2,4-Triazols, 1,3,4-Thiadiazols, and 1,3,4-Selenadiazoles from N-Tosylhydrazones

The diversity-oriented synthesis of 1,2,4-triazols, 1,3,4-thiadiazols, and 1,3,4-selenadiazoles from N-tosylhydrazones was developed, and the reactions were general for a wide range of substrates, in which NH2CN, KOCN, KSCN, and KSeCN were used as odorless sources. Two different pathways were proposed, and N-tosylhydrazonoyl chlorides were formed in situ in the presence of NCS.

Metal-free and highly regioselective synthesis of N-heteroaryl substituted pyrazoles from α,β-unsaturated N-tosylhydrazones and heteroaryl chlorides

A cascade cyclization/nucleophilic aromatic substitution (SNAr) reaction of α,β-unsaturated N-tosylhydrazones with N-heteroaryl chlorides was developed for the synthesis of N-heteroaryl pyrazole derivatives. This one-pot reaction provided bi(he

One-Pot Reaction between N-Tosylhydrazones and 2-Nitrobenzyl Bromide: Route to NH-Free C2-Arylindoles

A one-pot Barluenga coupling between N-tosylhydrazones and nitro-benzyl bromide, followed by deoxygenation of ortho-nitrostyrenes, and subsequent cyclization has been developed, providing a new way to synthesize various C2-arylindoles. This method exhibits a good substrate scope and functional group tolerance, and it allows an access to NH-free indoles, which can present a potential utility in medicinal chemistry applications.