7318-00-5

Basic information

• Product Name: 3-Amino-2-butenoic acid ethyl ester
• Synonyms: Ethyl (2E)-3-amino-2-butenoate;ETHYL 3-AMINO-2-BUTENOATE;ETHYL 3-AMINOCROTONATE;ETHYL (2E)-3-AMINOBUT-2-ENOATE;ETHYL BETA-AMINOCROTONATE;ETHYL B-IMINOBUTYRATE;3-AMINO-2-BUTENOIC ACID ETHYL ESTER;β-Aminocrotonic acid, ethyl ester
• CAS NO: 7318-00-5
• Molecular Formula: C₆H₁₁NO₂
• Molecular Weight: 129.16
• EINECS: 230-782-0
• Product Categories: API intermediates
• Mol File: 7318-00-5.mol
• Article Data: 46

Chemical Properties

• Melting Point: 33-35 °C(lit.)
• Boiling Point: 210-215 °C(lit.)
• Flash Point: 207 °F
• Appearance: Slightly yellow/Low Melting Solid or Liquid
• Density: 1.022 g/mL at 25 °C(lit.)
• Vapor Pressure: 0.173mmHg at 25°C
• Refractive Index: 1.5-1.502
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature
• PKA: 5.32±0.70(Predicted)
• CAS DataBase Reference: 3-Amino-2-butenoic acid ethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 3-Amino-2-butenoic acid ethyl ester(7318-00-5)
• EPA Substance Registry System: 3-Amino-2-butenoic acid ethyl ester(7318-00-5)

Safety Data

• Hazard Codes: C
• Statements: 34-36/37
• Safety Statements: 26-27-28-36/37/39-45-24/25
• RIDADR: UN 3263 8/PG 2
• WGK Germany: 3
• Hazardous Substances Data: 7318-00-5(Hazardous Substances Data)

Usage

Chemical Properties

Slightly yellow low melting solid or liquid

InChI:InChI=1/C6H11NO2/c1-3-9-6(8)4-5(2)7/h4H,3,7H2,1-2H3/b5-4-

Upstream product

• 4341-76-8 Ethyl 2-butynoate 
• 141-97-9 ethyl acetoacetate 
• 6127-92-0 E-Ethyl β-chlorocrotonate 
• 64-17-5 ethanol 
• 77570-17-3 5-(2-aminoethylidene)-2,2-dimethyl-1,3-dioxane-4,6-dione 
• 128001-87-6 ethyl 3-(bromoacetamido)crotonate 
• 105-56-6 ethyl 2-cyanoacetate 
• 7664-41-7 ammonia 
• 141-78-6 ethyl acetate 
• 412321-15-4 4-cyano-3-methyl-pentenedioic acid diethyl ester 
• 91558-49-5 2,3-dicyano-3-methyl-glutaric acid diethyl ester 
• 73758-52-8 3-amino-3-ureido-butyric acid ethyl ester 
• 56294-09-8 ethyl 5-methoxycarbonyl-3-oxopentanoate 
• 123-11-5 4-methoxy-benzaldehyde 

Downstream Products

• 115951-98-9 1,4-bis(2,6-dimethyl-3,5-diethoxycarbonyl-1,4-dihydropyridine-4-yl)benzene 
• 15866-05-4 6-methyl-2-thioxo-3-p-tolyl-2,3-dihydro-1H-pyrimidin-4-one 
• 70463-75-1 2-(1-amino-ethylidene)-N-(4-chloro-phenyl)-malonamic acid ethyl ester 
• 71814-38-5 3-[N'-(4-chloro-phenyl)-ureido]-crotonic acid ethyl ester 
• 21829-28-7 2,6-dimethyl-4-(3-nitro-phenyl)-1,4-dihydro-pyridine-3,5-dicarboxylic acid diethyl ester 
• 21881-54-9 2,6-dimethyl-4-(4-nitro-phenyl)-1,4-dihydro-pyridine-3,5-dicarboxylic acid diethyl ester 
• 3274-64-4 ethyl 2?methyl?4,5?diphenyl?1H?pyrrole?3?carboxylate 
• 23118-56-1 diethyl 2,6-dimethyl-4-(2-furyl)-1,4-dihydropyridine-3,5-dicarboxylate 
• 71160-18-4 4-(4-furan-2-yl-buta-1,3-dienyl)-2,6-dimethyl-1,4-dihydro-pyridine-3,5-dicarboxylic acid diethyl ester 
• 71160-16-2 2,6-dimethyl-4-[4-(5-nitro-furan-2-yl)-buta-1,3-dienyl]-1,4-dihydro-pyridine-3,5-dicarboxylic acid diethyl ester 
• 1149-23-1 diethyl 2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate 
• 632-93-9 diethyl 1,4-dihydro-2,4,6-trimethylpyridine-3,5-dicarboxylate 
• 22192-02-5 ethyl 1,4-dihydro-2,6-dimethyl-4-oxopyridine-3-carboxylate 
• 113293-80-4 ethyl 1,4-dihydro-2-methyl-4-(4-nitrophenyl)-6-phenyl-3-pyridinecarboxylate 

Relevant articles and documents

Efficient synthesis of decahydroacridine-1,8-diones and polyhydroquinolines using the step-wise method

Various symmetrical and unsymmetrical decahydroacridine-1,8-dione and polyhydroquinoline derivatives were synthesized via two-step cyclocondensation reactions. The advantages of this step-wise addition of reactants in comparison with other one-pot reactions are avoiding the formation of 2 or 3 undesired by-products, therefore allowing cleaner work up of reaction. The important factor of this effective cyclocondensation method is that the prepared β-enaminone component was added dropwise to the solution, in which the Knoevenagel condensation product is slowly being formed by reaction of aldehyde molecule and 1,3-dicarbonyl compounds. The results of the proposed step-wise method are compared and discussed with those obtained in the one-pot reactions.

Tetrasubstituted 1,3-Enynes by Gold-Catalyzed Direct C(sp2)-H Alkynylation of Acceptor-Substituted Enamines

A gold-catalyzed synthesis of tetrasubstituted 1,3-enynes from hypervalent iodine(III) reagents and activated alkenes is reported. This reaction involves an in situ formed alkynyl Au(III) species and a subsequent direct C(sp2)-H functionalization of alkenes, offering 26 enynes in 62-92% yield with excellent functional group tolerance.

Preparation method of 2-methoxy-6, 7-dihydro-5H-cyclopenta [b] pyridine-5-one

The invention relates to a preparation method of 2-methoxy-6,7-dihydro-5H-cyclopenta[b]pyridine-5-one. According to the preparation method, ethyl acetoacetate is used as a starting raw material, and anovel target product 2-methoxy-6, 7-dihydro-5H-cyclopenta[b]pyridine-5-one is prepared through nine steps of reactions including dehydration, addition, cyclization, chlorination, bromination, substitution, cyclization again, decarboxylation and etherification. The preparation method of the novel target product is simple and efficient. The purity of the novel target product prepared by the methoddisclosed by the invention reaches over 99.0%.