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73282-11-8

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73282-11-8 Usage

General Description

[1-(phenylsulfonyl)-1H-indol-2-yl]methanol is a chemical compound with a structure containing a phenylsulfonyl group attached to an indole ring, with a methanol group attached to the indole ring as well. [1-(PHENYLSULFONYL)-1H-INDOL-2-YL]METHANOL is used in medicinal chemistry and pharmaceutical research as a building block for the synthesis of various bioactive molecules. The phenylsulfonyl group and the indole ring are both known for their versatile reactivity and ability to participate in diverse chemical reactions, making this compound a valuable intermediate for the preparation of drug candidates and other biologically active compounds. Its unique structure and potential biological activity make it of interest for further study and exploration in the field of drug discovery and development.

Check Digit Verification of cas no

The CAS Registry Mumber 73282-11-8 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 7,3,2,8 and 2 respectively; the second part has 2 digits, 1 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 73282-11:
(7*7)+(6*3)+(5*2)+(4*8)+(3*2)+(2*1)+(1*1)=118
118 % 10 = 8
So 73282-11-8 is a valid CAS Registry Number.
InChI:InChI=1/C15H13NO3S/c17-11-13-10-12-6-4-5-9-15(12)16(13)20(18,19)14-7-2-1-3-8-14/h1-10,17H,11H2

73282-11-8SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 20, 2017

Revision Date: Aug 20, 2017

1.Identification

1.1 GHS Product identifier

Product name [1-(benzenesulfonyl)indol-2-yl]methanol

1.2 Other means of identification

Product number -
Other names 1-Phenylsulfonyl-1H-indole-2-methanol

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:73282-11-8 SDS

73282-11-8Relevant articles and documents

4-Substituted D-glutamic acid analogues: The first potent inhibitors of glutamate racemase (MurI) enzyme with antibacterial activity

De Dios, Alfonso,Prieto, Lourdes,Martín, Jose Alfredo,Rubio, Almudena,Ezquerra, Jesus,Tebbe, Mark,López De Uralde, Beatriz,Martín, Justina,Sánchez, Ana,LeTourneau, Deborah L.,McGee, James E.,Boylan, Carole,Parr Jr., Thomas R.,Smith, Michele C.

, p. 4559 - 4570 (2007/10/03)

The first potent inhibitors of glutamate racemase (MurI) enzyme that show whole cell antibacterial activity are described. Optically pure 4-substituted D-glutamic acid analogues with (2R,4S) stereochemistry and bearing aryl-, heteroaryl-, cinnamyl-, or biaryl-methyl substituents represent a novel class of glutamate racemase inhibitors. Exploration of the D-Glu core led to the identification of lead compounds (-)-8 and 10. 2-Naphthylmethyl derivative 10 was found to be a potent competitive inhibitor of glutamate racemase activity (Ki = 16 nM, circular dichroism assay; IC50 = 0.1 μg/mL high-performance liquid chromatography (HPLC) assay). Thorough structure-activity relationship (SAR) studies led to benzothienyl derivatives such as 69 and 74 with increased potency (IC50 = 0.036 and 0.01 μg/mL, respectively, HPLC assay). These compounds showed potent whole cell antibacterial activity against S. pneumoniae PN-R6, and good correlation with the enzyme assay. Compounds 69, 74 and biaryl derivative 52 showed efficacy in an in vivo murine thigh infection model against Streptococcus pneumoniae. Data described herein suggest that glutamate racemase may be a viable target for developing new antibacterial agents.

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