40899-71-6 Usage
Description
1-(Phenylsulfonyl)indole is an organic compound that features a sulfonyl group attached to a phenyl ring and is fused to an indole moiety. It is known for its unique chemical properties and potential applications in various fields due to its versatile structure.
Uses
Used in Pharmaceutical Industry:
1-(Phenylsulfonyl)indole is used as a reactant for the preparation of various pharmaceutical agents, including:
Antiplasmodial agents: These agents are used to treat malaria by targeting the Plasmodium parasite responsible for the disease.
Antifungal agents: These compounds are employed to combat fungal infections, providing a treatment option for various fungal-related conditions.
Anti-HIV-1 agents: These agents are designed to inhibit the replication of the Human Immunodeficiency Virus Type 1 (HIV-1), helping to manage and control the progression of the disease.
Agonists of the histamine H4 receptor: These agonists are used to modulate the histamine H4 receptor, which has been implicated in various immune and inflammatory responses, offering potential therapeutic applications.
Antibacterial agents: These compounds are utilized to combat bacterial infections, providing an alternative treatment option for various bacterial-related conditions.
Camalexin analogs: These analogs are derived from camalexin, a plant defense compound, and are being investigated for their potential applications in plant protection and human health.
CDK inhibitors and cytotoxic agents: These agents target cyclin-dependent kinases (CDKs), which play a crucial role in cell cycle regulation, and are being explored for their potential use in cancer therapy.
Histone Deacetylase (HDAC) inhibitors: These inhibitors target HDAC enzymes, which are involved in the regulation of gene expression, and are being investigated for their potential use in the treatment of various diseases, including cancer.
Synthesis Reference(s)
Synthesis, p. 136, 1979Tetrahedron Letters, 29, p. 2151, 1988 DOI: 10.1016/S0040-4039(00)86696-4
Check Digit Verification of cas no
The CAS Registry Mumber 40899-71-6 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 4,0,8,9 and 9 respectively; the second part has 2 digits, 7 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 40899-71:
(7*4)+(6*0)+(5*8)+(4*9)+(3*9)+(2*7)+(1*1)=146
146 % 10 = 6
So 40899-71-6 is a valid CAS Registry Number.
InChI:InChI=1/C14H11NO2S/c16-18(17,13-7-2-1-3-8-13)15-11-10-12-6-4-5-9-14(12)15/h1-11H
40899-71-6Relevant articles and documents
Substituent Effects on the Acid Hydration of Acetylenes
Allen, Annette D.,Chiang, Yvonne,Kresge, A. Jerry,Tidwell, Thomas T.
, p. 775 - 779 (1982)
The rates of hydration in aqueous sulfuric acid of 1-butyne, 2-butyne, 1-hexyne, 1-cyclopropylacetylene, and 1-butene are reported, together with rates in D2SO4 for the alkynes plus 3-hexyne.All of the compounds are proposed to react through the AdE2 mechanism of rate-limiting protonation on carbon.A general correlation of logkH+(alkyne)/log kH+(alkene) is observed, whose slope of 1.25 is a quantitative measure of the greater sensitivity to substituent effects of alkynes compared to alkenes in protonation.
Rationally designed N-phenylsulfonylindoles as a tool for the analysis of the non-basic 5-HT6R ligands binding mode
Staroń, Jakub,Bugno, Ryszard,Pietru?, Wojciech,Sata?a, Grzegorz,Mordalski, Stefan,Warszycki, Dawid,Hogendorf, Agata,Hogendorf, Adam S.,Kalinowska-T?u?cik, Justyna,Lenda, Tomasz,Pilarski, Bogus?aw,Bojarski, Andrzej J.
supporting information, (2020/10/26)
Among all of the monoaminergic receptors, the 5-HT6R has the highest number of non-basic ligands (approximately 5% of compounds stored in 25th version of ChEMBL database have the strongest basic pKa below 5, calculated using the Instant JChem c
Iodine-Mediated Electrochemical C(sp2)-H Amination: Switchable Synthesis of Indolines and Indoles
Hu, Kangfei,Zhang, Yan,Zhou, Zhenghong,Yang, Yu,Zha, Zhenggen,Wang, Zhiyong
supporting information, p. 5773 - 5777 (2020/08/05)
A metal-free electrochemical intramolecular C(sp2)-H amination using iodine as a mediator was developed. This method enables a switchable synthesis of indoline and indole derivatives, respectively, from easily available 2-vinyl anilines.
