40899-90-9

Basic information

• Product Name: phenyl[1-(phenylsulfonyl)-1H-indol-2-yl]methanone
• Synonyms: phenyl[1-(phenylsulfonyl)-1H-indol-2-yl]methanone
• CAS NO: 40899-90-9
• Molecular Formula: C₂₁H₁₅NO₃S
• Molecular Weight: 361.4137
• Mol File: 40899-90-9.mol
• Article Data: 8

Chemical Properties

• Boiling Point: 579.7°Cat760mmHg
• Flash Point: 304.4°C
• Appearance: /
• Density: 1.26g/cm³
• Vapor Pressure: 1.96E-13mmHg at 25°C
• Refractive Index: 1.648
• CAS DataBase Reference: phenyl[1-(phenylsulfonyl)-1H-indol-2-yl]methanone(CAS DataBase Reference)
• NIST Chemistry Reference: phenyl[1-(phenylsulfonyl)-1H-indol-2-yl]methanone(40899-90-9)
• EPA Substance Registry System: phenyl[1-(phenylsulfonyl)-1H-indol-2-yl]methanone(40899-90-9)

Safety Data

• Hazardous Substances Data: 40899-90-9(Hazardous Substances Data)

Usage

General Description

Phenyl[1-(phenylsulfonyl)-1H-indol-2-yl]methanone, also known as PSI, is a chemical compound with the molecular formula C22H15NO2S. It belongs to the class of indole derivatives and is commonly used in pharmaceutical research as a potential drug candidate for various medical conditions. PSI is known for its inhibitory effects on enzymes such as tryptophan 2,3-dioxygenase, which plays a role in immune modulation and the kynurenine pathway. It has also been studied for its potential anti-inflammatory and antitumor properties, making it a subject of interest in drug development and medicinal chemistry. Additionally, PSI has been reported to exhibit cytotoxic effects on various cancer cell lines, highlighting its potential as a therapeutic agent for cancer treatment. However, further research is needed to fully understand and harness the pharmacological potential of this compound.

InChI:InChI=1/C21H15NO3S/c23-21(16-9-3-1-4-10-16)20-15-17-11-7-8-14-19(17)22(20)26(24,25)18-12-5-2-6-13-18/h1-15H

Upstream product

• 40899-71-6 1-benzenesulfonylindole 
• 98-88-4 benzoyl chloride 
• 151721-32-3 N-benzenesulfonyl-o-aminobenzaldehyde 
• 98-09-9 benzenesulfonyl chloride 
• 197847-57-7 N-[2-(hydroxymethyl)phenyl]benzenesulfonamide 
• 5344-90-1 2-Aminobenzyl alcohol 
• 50707-35-2 2-benzoyl-2,3-dihydro-isoindol-1-one 
• 93-97-0 benzoic acid anhydride 
• 591-50-4 iodobenzene 
• 201230-82-2 carbon monoxide 

Downstream Products

• 1022-86-2 2-benzoylindole 

Relevant articles and documents

One-pot synthesis of 1-phenylsulfonyl-2-aroylindoles

Interaction of phenylsulfonyl-2-aminobenzaldehyde with 2-bromo-1- phenylethanones in the presence of K2CO3 followed by acid-catalyzed dehydration led to the formation of 1-phenylsulfonyl-2-aroylindoles.Copyright Taylor & Francis Group, LLC.

Bis(1H-2-indolyl)methanones as a novel class of inhibitors of the platelet-derived growth factor receptor kinase

The novel lead bis(1H-2-indolyl)methanone inhibits autophosphorylation of platelet-derived growth factor (PDGF) receptor tyrosine kinase in intact cells. Various substituents in the 5- or 6-position of one indole ring increase or preserve potency, whereas

Synthetic 2-aroylindole derivatives as a new class of potent tubulin-inhibitory, antimitotic agents

A new class of simple synthetic antimitotic compounds based on 2-aroylindoles was discovered. (5-Methoxy-1H-2-indolyl)-phenylmethanone (1) as well as analogous 3-fluorophenyl- (36) and 3-methoxyphenyl (3) derivatives displayed high cytotoxicity of IC