73340-44-0

Basic information

• Product Name: 3',5,6,7,8-Pentamethoxy-4',5'-(methylenedioxy)flavone
• Synonyms: 3',5,6,7,8-Pentamethoxy-4',5'-(methylenedioxy)flavone;5,6,7,8-Tetramethoxy-2-(7-methoxy-1,3-benzodioxol-5-yl)-4H-1-benzopyran-4-one;Eupalestin
• CAS NO: 73340-44-0
• Molecular Formula: C₂₁H₂₀O₉
• Molecular Weight: 416.38
• Mol File: 73340-44-0.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 616.1°C at 760 mmHg
• Flash Point: 269.1°C
• Appearance: /
• Density: 1.341g/cm³
• Vapor Pressure: 4.13E-15mmHg at 25°C
• Refractive Index: 1.583
• CAS DataBase Reference: 3',5,6,7,8-Pentamethoxy-4',5'-(methylenedioxy)flavone(CAS DataBase Reference)
• NIST Chemistry Reference: 3',5,6,7,8-Pentamethoxy-4',5'-(methylenedioxy)flavone(73340-44-0)
• EPA Substance Registry System: 3',5,6,7,8-Pentamethoxy-4',5'-(methylenedioxy)flavone(73340-44-0)

Safety Data

• Hazardous Substances Data: 73340-44-0(Hazardous Substances Data)

Usage

General Description

3',5,6,7,8-Pentamethoxy-4',5'-(methylenedioxy)flavone is a natural chemical compound found in several plants, including Kaempferia parviflora. It is a flavonoid, a type of antioxidant compound known for its potential health benefits. The chemical structure of 3',5,6,7,8-Pentamethoxy-4',5'-(methylenedioxy)flavone consists of five methoxy groups attached to the flavone backbone, along with a methylenedioxy group located at positions 4' and 5'. This specific arrangement of functional groups gives the compound its unique properties and potential biological activities. Studies have shown that 3',5,6,7,8-Pentamethoxy-4',5'-(methylenedioxy)flavone may exhibit anti-inflammatory, antioxidant, and anti-cancer properties, making it of interest for potential use in medicine and functional foods. Further research is needed to fully understand its potential benefits and mechanisms of action.

InChI:InChI=1/C21H20O9/c1-23-13-6-10(7-14-16(13)29-9-28-14)12-8-11(22)15-17(24-2)19(25-3)21(27-5)20(26-4)18(15)30-12/h6-8H,9H2,1-5H3

Upstream product

• 3162-28-5 2-hydroxy-3,4,5,6-tetramethoxyacetophenone 
• 76015-47-9 7-methoxy-benzo[1,3]dioxole-5-carbonyl chloride 
• 5780-07-4 3-methoxy-4,5-methylenedioxybenzaldehyde 

Downstream Products

• 22934-58-3 methyl 7-methoxybenzo[d][1,3]dioxole-5-carboxylate 
• 526-34-1 5-methoxy-3,4-methylenedioxybenzoic acid 
• 3162-28-5 2-hydroxy-3,4,5,6-tetramethoxyacetophenone 

Relevant articles and documents

Synthesis of Polymethoxyflavonoids from Hesperidin and Naringin and their Antiproliferative Activity

[Figure not available: see fulltext.] A series of polymethoxyflavonoids were synthesized via cleavage of the glycosidic bond, dehydrogenation, selective methylation, bromination, nucleophilic aromatic substitution, O-prenylation, Claisen–Schmidt aldol condensation, cyclization, and oxidation from very abundant and inexpensive natural flavonoids hesperidin and naringin. The in vitro antiproliferative activity of the synthesized compounds was evaluated against a panel of four human cancer cell lines (Aspc-1, HCT-116, HepG-2, and SUN-5) by the CellTiter-Glo assay. The results showed that some of synthesized compounds exhibited moderate to high antiproliferative activity. Among them, (2E)-1-(2-hydroxy-3,4,5,6-tetramethoxyphenyl)-3-(7-methoxy-1,3-benzodioxol-5-yl)prop-2-en-1-one was revealed to be the most active with IC50 values ranging from 10.35 to 13.89 μM against all four cancer cell lines, the IC50 value (10.35 μM) being below positive control cisplatin (12.36 μM) against HepG-2 cells.