73486-13-2

Basic information

• Product Name: 2-(3-Cyclohexyl-3-oxo-propylamino)-6-ethoxycarbonylmethoxy-hexanoic acid ethyl ester
• CAS NO: 73486-13-2
• Molecular Weight: 399.528
• Mol File: 73486-13-2.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 2-(3-Cyclohexyl-3-oxo-propylamino)-6-ethoxycarbonylmethoxy-hexanoic acid ethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(3-Cyclohexyl-3-oxo-propylamino)-6-ethoxycarbonylmethoxy-hexanoic acid ethyl ester(73486-13-2)
• EPA Substance Registry System: 2-(3-Cyclohexyl-3-oxo-propylamino)-6-ethoxycarbonylmethoxy-hexanoic acid ethyl ester(73486-13-2)

Safety Data

• Hazardous Substances Data: 73486-13-2(Hazardous Substances Data)

Upstream product

• 147697-75-4 Diethyl 2-acetamido-2-ethoxycarbonyl-7-oxanonanedioate 
• 54131-75-8 ethyl 4-bromobutoxyacetate 
• 2177-34-6 1-cyclohexylprop-2-en-1-one 
• 147697-63-0 (E)-Diethyl 2-amino-7-thianon-4,5-enedioate 
• 65706-45-8 Diethyl 2-amino-7-oxanonanedioate 

Downstream Products

• 73486-26-7 2-(3-Cyclohexyl-3-hydroxy-propylamino)-6-ethoxycarbonylmethoxy-hexanoic acid ethyl ester 

Relevant articles and documents

Synthesis and platelet aggregation inhibiting activity of acid side-chain modified hydantoin prostaglandin analogues

A series of hydantoin prostaglandin analogues, in which the hexamethylene moiety of the acid side chain was replaced by other spacing groups possessing either ether, sulphide and/or olefin functionality, were prepared and evaluated for platelet aggregation inhibiting activity. The 4-thia analogue 13 proved to be the most potent inhibitor (ca. 22x PGE1) and the 3-thia- and 3-oxa-analogues, 6 and 10 respectively, are approximately equipotent with BW245C (ca. 14x PGE1). Z-olefinic analogues (e.g. 11) were usually more potent than their E-isomers (e.g. 12). Structure-activity relationships are discussed in detail.