73544-82-8

Basic information

• Product Name: 3-Oxybenz-4-chloranilid
• Synonyms: 3-Oxybenz-4-chloranilid
• CAS NO: 73544-82-8
• Molecular Weight: 247.681
• Mol File: 73544-82-8.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 3-Oxybenz-4-chloranilid(CAS DataBase Reference)
• NIST Chemistry Reference: 3-Oxybenz-4-chloranilid(73544-82-8)
• EPA Substance Registry System: 3-Oxybenz-4-chloranilid(73544-82-8)

Safety Data

• Hazardous Substances Data: 73544-82-8(Hazardous Substances Data)

Upstream product

• 106-47-8 4-chloro-aniline 
• 99-06-9 3-Carboxyphenol 

Relevant articles and documents

Discovery of potent c-MET inhibitors with new scaffold having different quinazoline, pyridine and tetrahydro-pyridothienopyrimidine headgroups

Cellular mesenchymal-epithelial transition factor (c-MET) is closely linked to human malignancies, which makes it an important target for treatment of cancer. In this study, a series of 3-methoxy-N-phenylbenzamide derivatives, N-(3-(tert-butyl)-1-phenyl-1H-pyrazol-5-yl) benzamide derivatives and N1-(3-fluoro-4-methoxyphenyl)-N3-(4-fluorophenyl) malonamide derivatives were designed and synthesized, some of them were identified as c-MET inhibitors. Among these compounds with new scaffolds having different quinazoline, pyridine and tetrahydro-pyridothienopyrimidine head groups, compound 11c, 11i, 13b, 13h exhibited both potent inhibitory activities against c-MET and high anticancer activity against tested cancer cell lines in vitro. In addition, kinase selectivity assay further demonstrated that both 13b and 13h are potent and selective c-MET inhibitors. Molecular docking supported that they bound well to c-MET and VEGFR2, which demonstrates that they are potential c-MET RTK inhibitors for cancer therapy.