73655-51-3

Basic information

• Product Name: 4-Amino-2-iodobenzoic acid
• Synonyms: 4-Amino-2-iodobenzoic acid
• CAS NO: 73655-51-3
• Molecular Formula: C₇H₆INO₂
• Molecular Weight: 263.03
• Mol File: 73655-51-3.mol
• Article Data: 6

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 4-Amino-2-iodobenzoic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Amino-2-iodobenzoic acid(73655-51-3)
• EPA Substance Registry System: 4-Amino-2-iodobenzoic acid(73655-51-3)

Safety Data

• Hazardous Substances Data: 73655-51-3(Hazardous Substances Data)

Upstream product

• 150-13-0 4-amino-benzoic acid 
• 619-17-0 4-Nitroanthranilic acid 
• 7745-92-8 2-iodo-1-methyl-4-nitrobenzene 
• 126116-23-2 4-acetamido-2-iodobenzoic acid 
• 89459-38-1 4-nitro-2-iodobenzoic acid 
• 97113-36-5 3-iodo-4-methylacetanilide 
• 35944-64-0 3-iodo-4-methylaniline 
• 112391-34-1 4-nitro-2-iodosobenzoic acid 
• 7664-41-7 ammonia 

Downstream Products

• 126116-25-4 4-(N-acetyl-L-tyrosyl)amino-2-iodobenzoic acid 
• 126116-24-3 4-(N,O-diacetyl-L-tyrosyl)amino-2-iodobenzoic acid 
• 116631-87-9 4-hydroxy-2-iodo-benzoic acid 

Relevant articles and documents

5,8-DISUBSTITUTED-[1,2,4]TRIAZOLO[1,5-A]PYRIDINYL AND 5,8-DISUBSTITUTED-IMIDAZO[1,2-A]PYRIDINE DERIVATIVES USEFUL AS INHIBITORS OF ENTEROPEPTIDASE

The present invention is directed to 5,8-disubstituted-[1,2,4]triazolo[1,5- a]pyridinyl and 5,8-disubstituted-imidazo[1,2-a]pyridine derivatives, pharmaceutical compositions containing them and their use in the treatment of disorders and conditions modulated by the enteropeptidase enzyme.

Singlet Oxygen Generation from a Water-Soluble Hypervalent Iodine(V) Reagent AIBX and H2O2: An Access to Artemisinin

Herein, we report an efficient method for the chemical generation of 1O2 by treatment of H2O2 with AIBX, a highly water-soluble, bench-stable, recyclable hypervalent iodine(V) reagent developed by our group. The generation of 1O2 was confirmed by the following results: (1) capture of 1O2 with the sodium salt of anthracene-9,10-bis(ethanesulfonate) produced the corresponding endoperoxide and (2) TEMPO (2,2,6,6-tetramethyl-1-piperidinyloxy) produced by the oxidation of 2,2,6,6-tetramethylpiperidine with 1O2 generated using the AIBX/H2O2 system was detected by electron spin resonance spectroscopy. To illustrate the potential utility of this method for organic synthesis, we used the AIBX/H2O2 system to perform typical reactions of 1O2: [2 + 2]/[4 + 2] cycloadditions, Schenck ene reactions, and heteroatom oxidation reactions, which afforded the corresponding products in high yields. Moreover, we used the method to synthesize the antimalarial drug artemisinin. Finally, we demonstrated that AIBX could be regenerated after the reaction by means of a workup involving extraction and removal of water to obtain a precursor of AIBX, which could then be re-oxidized.

SYNTHESIS OF 4-(N-ACETYL-L-TYROSYL)AMINO-2-IODOBENZOIC ACID

The title compound was prepared by a three-step synthesis from diacetyltyrosine (XV) and 4-amino-2-iodobenzoic acid (I).Syntheses of acid I and 4-amino-3-iodobenzoic acid (II) have been revised and modified. 1H and 13C NMR spectra of the synthesized compo