736930-12-4

Basic information

• Product Name: N-(2-bromo-4,5-dimethoxybenzyl)-5-quinolinamine
• CAS NO: 736930-12-4
• Molecular Weight: 373.249
• Mol File: 736930-12-4.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: N-(2-bromo-4,5-dimethoxybenzyl)-5-quinolinamine(CAS DataBase Reference)
• NIST Chemistry Reference: N-(2-bromo-4,5-dimethoxybenzyl)-5-quinolinamine(736930-12-4)
• EPA Substance Registry System: N-(2-bromo-4,5-dimethoxybenzyl)-5-quinolinamine(736930-12-4)

Safety Data

• Hazardous Substances Data: 736930-12-4(Hazardous Substances Data)

Upstream product

• 736930-16-8 C₁₈H₁₅BrN₂O₂ 
• 5392-10-9 2-bromo-4,5-dimethoxybenzaldehyde 
• 611-34-7 5-Aminoquinoline 
• 53207-00-4 1-bromo-2-(bromomethyl)-4,5-dimethoxybenzene 

Relevant articles and documents

Synthesis and cytotoxic activity of benzo[c][1,7] and [1,8]phenanthrolines analogues of nitidine and fagaronine

Fagaronine and nitidine are natural benzo[c] phenanthridinium alkaloids, which display antileukemic activity. Both act as topoisomerase I and topoisomerase II inhibitors. The objective of the present study was to prepare noncharged isosters of these compounds, with replacement of the aromatic A ring by a pyridine ring, present in other topoisomerase I inhibitors. Various 7,8- and 8,9-dimethoxy and metylenedioxy benzo[c][1,7] and [1,8]phenanthrolines were readily synthesized by benzyne-mediated cyclization of the corresponding substituted N-(2-halobenzyl)-5-quinolinamines or 5-isoquinolinamines. In both series, compounds bearing oxygenated substituents at positions 8 and 9 exhibited cytotoxic properties towards L1210 murine leukemia cells, which may result from their capacities to intercalate into DNA. Topoisomerase I inhibition was observed for all active compounds.