73948-23-9Relevant articles and documents
Effects of lipophilicity, protecting group and stereochemistry on the antimalarial activity of carbohydrate-derived thiochromans
Madumo, Gilbert K.,Moshapo, Paseka T.,Kinfe, Henok H.
, p. 817 - 833 (2018/01/10)
A series of novel carbohydrate-derived thiochromans has been successfully synthesized in order to investigate the influence of alkyl substituents on the aromatic ring of the thiophenol moiety in addition to the effect of protecting groups and stereochemistry on the sugar component of the target molecules. Results from the evaluation of the thiochromans for their antimalarial activity against the chloroquine-sensitive (3D7) strain of Plasmodium falciparum suggest that the presence of short chain alkyl substituents, a benzyl ether protecting group and equatorial orientation of the C-4 substituent on the sugar moiety are crucial structural features that impart high antimalarial activity.
SMALL MOLECULE INHIBITORS OF THE PLECKSTRIN HOMOLOGY DOMAIN AND METHODS FOR USING SAME
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Page/Page column 100-101, (2009/12/02)
Pleckstrin homology domain binding compounds, pharmaceutical compositions including such compounds, and methods for their use are described herein.
Photochromism of Hemithioindigo Derivatives. I. Preparation and Photochromic Properties in Organic Solvents
Yamaguchi, Takeo,Seki, Takahiro,Tamaki, Takashi,Ichimura, Kunihiro
, p. 649 - 656 (2007/10/02)
Thirteen hemithioindigo (HT) derivatives bearing alkyl chains are newly synthesized and their photochromism and emission properties are investigated.The Z/E photoisomerisms of these compounds in organic solvents are essentially in agreeement with data reported by Mostoslavskii and Izmail'skii (J.Gen.Chem.USSR, Engl Transl.), 31, 21 (1961), and subsequent papers).At 77 K both the E and Z isomers of HT chromophore emit fluoresscences of comparable intensities, whereas at room temperature very weak fluorescence is observed only from the Z isomer.Examination of repeatable numbers of Z/E photoisomerization reveals that the HT chromophore possesses remarkable inherent photofatigue resistance.