74011-39-5

Basic information

• Product Name: 3-Quinolinecarboxylic acid, 1-ethyl-6-fluoro-1,4-dihydro-7-[4-[(4-nitrophenyl)methyl]-1-piperazinyl]-4- oxo-
• CAS NO: 74011-39-5
• Molecular Formula: C23H23FN4O5
• Molecular Weight: 454.458
• Mol File: 74011-39-5.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 3-Quinolinecarboxylic acid, 1-ethyl-6-fluoro-1,4-dihydro-7-[4-[(4-nitrophenyl)methyl]-1-piperazinyl]-4- oxo-(CAS DataBase Reference)
• NIST Chemistry Reference: 3-Quinolinecarboxylic acid, 1-ethyl-6-fluoro-1,4-dihydro-7-[4-[(4-nitrophenyl)methyl]-1-piperazinyl]-4- oxo-(74011-39-5)
• EPA Substance Registry System: 3-Quinolinecarboxylic acid, 1-ethyl-6-fluoro-1,4-dihydro-7-[4-[(4-nitrophenyl)methyl]-1-piperazinyl]-4- oxo-(74011-39-5)

Safety Data

• Hazardous Substances Data: 74011-39-5(Hazardous Substances Data)

Upstream product

• 70458-96-7 1-ethyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-3-quinoline carboxylic acid 
• 100-11-8 1-bromomethyl-4-nitro-benzene 
• 367-21-5 3-chloro-4-fluorophenylamine 
• 68077-26-9 7-chloro-1-ethyl-6-fluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid 
• 70458-94-5 1-ethyl-6-fluoro-7-chloro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid ethyl ester 
• 74011-47-5 ethyl 1-ethyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,4-dihydroquinoline-3-carboxylate 
• 70032-30-3 diethyl 2-[(3-chloro-4-fluorophenylamino)methylene]malonate 
• 70458-93-4 7-Chloro-6-fluoro-4-hydroxy-3-quinolinecarboxylic acid ethyl ester 
• 75001-56-8 6-Fluoro-4-hydroxy-7-piperazin-1-yl-quinoline-3-carboxylic acid ethyl ester 

Downstream Products

• 75338-39-5 1-ethyl-7-[(4-p-aminobenzyl)-1-piperazinyl]-1,4-dihydro-6-fluoro-4-oxo-quinoline-3-carboxylic acid hydrochloride 
• 74011-41-9 1-ethyl-6-fluoro-1,4-dihydro-4-oxo-7-<4-(p-aminobenzyl)-1-piperazinyl>quinoline-3-carboxylic acid 

Relevant articles and documents

Structure-Activity Relationships of Antibacterial 6,7- and 7,8-Disubstituted 1-Alkyl-1,4-dihydro-4-oxoquinoline-3-carboxylic Acids

Previous quantitative and qualitative structure-activity studies in antibacterial monosubstituted 1-ethyl-1,4-dihydro-4-oxoquinoline-3-carboxylic acids prompted us to synthesize the 6,7,8-polysubstituted compounds.In this paper, the preparation and antibacterial activity of the 6,7- and 7,8-disubstituted compounds and their derivatives are described.Among these compounds, 1-ethyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)quinoline-3-carboxylic acid (34) possessed many significant activities and was more active than oxolinic acid (84) against Gram-positive andGram-negative bacteria.Structure activity relationships are discussed.