70458-94-5

Basic information

• Product Name: ETHYL 7-CHLORO-1-ETHYL-6-FLUORO-1,4-DIHYDRO-4-OXO-QUINOLINE-5-CARBOXYLATE
• Synonyms: ETHYL 7-CHLORO-1-ETHYL-6-FLUORO-1,4-DIHYDRO-4-OXO-QUINOLINE-5-CARBOXYLATE;Ethyl 7-chloro-1-ethyl-6-fluoro-1,4-dihydro-4-oxoquinoline-3-carboxylate;Norfloxacin Impurity 5
• CAS NO: 70458-94-5
• Molecular Formula: C₁₄H₁₃ClFNO₃
• Molecular Weight: 297.71
• Mol File: 70458-94-5.mol
• Article Data: 4

Chemical Properties

• Melting Point: 139-141 °C
• Boiling Point: 425.2±45.0 °C(Predicted)
• Appearance: /
• Density: 1.335±0.06 g/cm3(Predicted)
• Storage Temp.: Room Temperature
• Solubility: Dichloromethane, DMSO, Ethyl Acetate, Methanol
• PKA: 0.35±0.70(Predicted)
• CAS DataBase Reference: ETHYL 7-CHLORO-1-ETHYL-6-FLUORO-1,4-DIHYDRO-4-OXO-QUINOLINE-5-CARBOXYLATE(CAS DataBase Reference)
• NIST Chemistry Reference: ETHYL 7-CHLORO-1-ETHYL-6-FLUORO-1,4-DIHYDRO-4-OXO-QUINOLINE-5-CARBOXYLATE(70458-94-5)
• EPA Substance Registry System: ETHYL 7-CHLORO-1-ETHYL-6-FLUORO-1,4-DIHYDRO-4-OXO-QUINOLINE-5-CARBOXYLATE(70458-94-5)

Safety Data

• Hazardous Substances Data: 70458-94-5(Hazardous Substances Data)

Usage

Description

ETHYL 7-CHLORO-1-ETHYL-6-FLUORO-1,4-DIHYDRO-4-OXO-QUINOLINE-5-CARBOXYLATE, also known as Norfloxacin Impurity 5, is a chemical compound derived from the synthesis of Norfloxacin, an antibacterial agent. It is characterized by its quinoline-based structure with a chloro, ethyl, and fluoro substituents, and a carboxylate group. ETHYL 7-CHLORO-1-ETHYL-6-FLUORO-1,4-DIHYDRO-4-OXO-QUINOLINE-5-CARBOXYLATE has gained attention due to its presence as a contaminant of emerging concern (CECs) in the pharmaceutical industry.

Uses

Used in Pharmaceutical Industry:
ETHYL 7-CHLORO-1-ETHYL-6-FLUORO-1,4-DIHYDRO-4-OXO-QUINOLINE-5-CARBOXYLATE is used as an impurity in the production of Norfloxacin (N681000), an antibacterial agent. Its presence as a contaminant of emerging concern (CECs) highlights the need for monitoring and controlling its levels to ensure the safety and efficacy of the final pharmaceutical product.
Additionally, due to its structural similarity to Norfloxacin, research into its potential applications and effects on human health is essential. This may include studying its interactions with biological systems, potential side effects, and any possible therapeutic uses that could be developed in the future.

Upstream product

• 86393-34-2 2,4-dichloro-5-fluorobenzoyl chloride 
• 74-96-4 ethyl bromide 
• 70458-93-4 7-Chloro-6-fluoro-4-hydroxy-3-quinolinecarboxylic acid ethyl ester 

Downstream Products

• 81530-83-8 1-ethyl-6-fluoro-7-(4-methyl-1-piperazinyl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid ethyl ester 
• 68077-27-0 Norfloxacin hydrochloride 
• 70458-99-0 1-ethyl-6-fluoro-7-(4-benzylpiperazin-1-yl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid 
• 74011-41-9 1-ethyl-6-fluoro-1,4-dihydro-4-oxo-7-<4-(p-aminobenzyl)-1-piperazinyl>quinoline-3-carboxylic acid 
• 70458-97-8 7-(4-allylpiperazin-1-yl)-1-ethyl-6-fluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid 
• 70458-96-7 1-ethyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-3-quinoline carboxylic acid 
• 70458-92-3 Pefloxacin 
• 74011-39-5 1-ethyl-1,4-dihydro-6-fluoro-7-[4-(p-nitrobenzyl)-1-piperazinyl]-4-oxoquinoline-3-carboxylic acid 
• 75001-81-9 7-(4-Benzoyl-piperazin-1-yl)-1-ethyl-6-fluoro-4-oxo-1,4-dihydro-quinoline-3-carboxylic acid 
• 74011-42-0 Oxonorfloxacin 
• 75001-82-0 1-ethyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)quinoline 
• 74011-56-6 N-acetylnorfloxacin 
• 68077-26-9 7-chloro-1-ethyl-6-fluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid 

Relevant articles and documents

Chemical synthesis method for norfloxacin

The invention discloses a chemical synthesis method for norfloxacin. The chemical synthesis method comprises the following steps: (1) synthesis of a compound ethyl quinolinate: 3-ethylamino-2-(2,4-dichloro-5-fluorobenzoyl) ethyl acrylate is dissolved in DMF, potassium carbonate is added, the mixture is heated to 50-80 DEG C, reacts and stands overnight, a product is cooled and poured into cold water, produced solids are filtered, solids are washed with a large amount of water, and the product ethyl quinolinate is obtained; (2) synthesis of a compound quinolinic acid: ethyl quinolinate is dissolved in methanol, hydrochloric acid is added in a ratio being 1:1, reflux is performed for 2 h, white solids are precipitated and filtered, a filter product is washed with water and dried in a vacuum oven for 2 h, and the product quinolinic acid is obtained. The design is reasonable, and one novel norfloxacin synthesis method is selected and has good market application value.

7-(substituted)piperazinyl-1-ethyl-6-fluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acids

7-(substituted)piperazinyl-1-ethyl-6-fluoro-4-oxo-3-quinolinecarboxylic acids, the pharmacologically acceptable salts thereof, compositions containing them, processes and intermediates for producing them, and methods of using them to treat bacterial infections in warm-blooded animals.