75001-82-0

Basic information

• Product Name: Norfloxacin EP Impurity D
• Synonyms: Norfloxacin EP Impurity D
• CAS NO: 75001-82-0
• Molecular Formula: C15H18FN3O
• Molecular Weight: 275.3213232
• Mol File: 75001-82-0.mol
• Article Data: 3

Chemical Properties

• Melting Point: 218.5-220.0 °C
• Boiling Point: 470.5±45.0 °C(Predicted)
• Appearance: /
• Density: 1.211±0.06 g/cm3(Predicted)
• PKA: 8.68±0.10(Predicted)
• CAS DataBase Reference: Norfloxacin EP Impurity D(CAS DataBase Reference)
• NIST Chemistry Reference: Norfloxacin EP Impurity D(75001-82-0)
• EPA Substance Registry System: Norfloxacin EP Impurity D(75001-82-0)

Safety Data

• Hazardous Substances Data: 75001-82-0(Hazardous Substances Data)

Upstream product

• 959774-07-3 7-(4-formylpiperazin-1-yl)-1-ethyl-6-fluoroquinoline-4-one 
• 70032-30-3 diethyl 2-[(3-chloro-4-fluorophenylamino)methylene]malonate 
• 74011-47-5 ethyl 1-ethyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,4-dihydroquinoline-3-carboxylate 
• 70458-94-5 1-ethyl-6-fluoro-7-chloro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid ethyl ester 
• 68077-26-9 7-chloro-1-ethyl-6-fluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid 
• 367-21-5 3-chloro-4-fluorophenylamine 
• 70458-96-7 1-ethyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-3-quinoline carboxylic acid 
• 75001-56-8 6-Fluoro-4-hydroxy-7-piperazin-1-yl-quinoline-3-carboxylic acid ethyl ester 
• 70458-93-4 7-Chloro-6-fluoro-4-hydroxy-3-quinolinecarboxylic acid ethyl ester 

Relevant articles and documents

Synthesis and biological evaluation of 6-fluoro-3-phenyl-7-piperazinyl quinolone derivatives as potential topoisomerase I inhibitors

The design and synthesis of a new series of 6-fluoro-3-phenyl-7-piperazinyl quinolone derivatives, built on the structure of 1-ethyl-3-(6-nitrobenzoxazol-2-yl)-6,8-difluoro-7-(3-methylpiperazin-1-yl)-4(1H)-quinolone, are described. These compounds provide

Structure-Activity Relationships of Antibacterial 6,7- and 7,8-Disubstituted 1-Alkyl-1,4-dihydro-4-oxoquinoline-3-carboxylic Acids

Previous quantitative and qualitative structure-activity studies in antibacterial monosubstituted 1-ethyl-1,4-dihydro-4-oxoquinoline-3-carboxylic acids prompted us to synthesize the 6,7,8-polysubstituted compounds.In this paper, the preparation and antibacterial activity of the 6,7- and 7,8-disubstituted compounds and their derivatives are described.Among these compounds, 1-ethyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)quinoline-3-carboxylic acid (34) possessed many significant activities and was more active than oxolinic acid (84) against Gram-positive andGram-negative bacteria.Structure activity relationships are discussed.