68077-27-0

Basic information

• Product Name: Norfloxacinehydrochloride
• Synonyms: Hydrochloric acid and norfloxacin;NorfloxacineHCl;Norfloxacinehydrochloride
• CAS NO: 68077-27-0
• Molecular Formula: C₁₆H₁₈FN₃O₃*ClH
• Molecular Weight: 355.7917632
• Mol File: 68077-27-0.mol
• Article Data: 7

Chemical Properties

• Appearance: /
• CAS DataBase Reference: Norfloxacinehydrochloride(CAS DataBase Reference)
• NIST Chemistry Reference: Norfloxacinehydrochloride(68077-27-0)
• EPA Substance Registry System: Norfloxacinehydrochloride(68077-27-0)

Safety Data

• Hazard Codes: F,C
• Statements: 11-34
• Safety Statements: 16-26-36/37/39-45
• Hazardous Substances Data: 68077-27-0(Hazardous Substances Data)

Usage

General Description

Norfloxacinehydrochloride is a synthetic antibiotic belonging to the fluoroquinolone class, and is used to treat bacterial infections. It works by inhibiting the bacterial DNA gyrase, preventing DNA replication and leading to the death of the bacteria. The hydrochloride form of norfloxacine helps to increase its solubility in water, making it more readily available for absorption in the body. This chemical is commonly used to treat urinary tract infections, gastrointestinal infections, and various other bacterial infections. However, it should be used with caution and under the guidance of a healthcare professional, as it may cause side effects and interact with other medications.

Upstream product

• 100505-08-6 1-ethyl-6,7-difluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid,ethyl ester 
• 121873-01-6 6,7-difluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid ethyl ester 
• 318685-01-7 ethyl 4-chloro-6,7-difluoroquinoline-3-carboxylate 
• 110-85-0 piperazine 
• 68077-26-9 7-chloro-1-ethyl-6-fluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid 
• 127142-90-9 7-{4-[(tert-butoxy)carbonyl]piperazin-1-yl}-1-ethyl-6-fluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid 
• 70458-96-7 1-ethyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-3-quinoline carboxylic acid 
• 75073-15-3 ethyl 7-chloro-6-fluoro-4-oxo-1,4-dihydroquinoline 3-carboxylate 
• 70458-94-5 1-ethyl-6-fluoro-7-chloro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid ethyl ester 

Downstream Products

• 1393937-97-7 7-(4-(N-(3-chlorophenylsulfonyl)carbamimidoyl)piperazin-1-yl)-1-ethyl-6-fluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid 
• 1393937-95-5 1-ethyl-6-fluoro-4-oxo-7-(4-(N-(2-(trifluoromethyl)phenylsulfonyl)carbamimidoyl)piperazin-1-yl)-1,4-dihydroquinoline-3-carboxylic acid 
• 1393937-93-3 7-(4-(N-(2-chlorophenylsulfonyl)carbamimidoyl)piperazin-1-yl)-1-ethyl-6-fluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid 
• 1393937-90-0 1-ethyl-6-fluoro-4-oxo-7-(4-(N-(4-(trifluoromethyl)phenylsulfonyl)carbamimidoyl)piperazin-1-yl)-1,4-dihydroquinoline-3-carboxylic acid 
• 1393937-87-5 7-(4-(N-(4-chlorophenylsulfonyl)carbamimidoyl)piperazin-1-yl)-1-ethyl-6-fluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid 
• 1393937-84-2 1-ethyl-6-fluoro-4-oxo-7-(4-(N-tosylcarbamimidoyl)piperazin-1-yl)-1,4-dihydroquinoline-3-carboxylic acid 
• 1393937-82-0 1-ethyl-6-fluoro-4-oxo-7-(4-(N-(phenylsulfonyl)carbamimidoyl)piperazin-1-yl)-1,4-dihydroquinoline-3-carboxylic acid 

Relevant articles and documents

Preparation method of quinolone carboxylic acid derivative or phthalazinone carboxylic acid derivative

The invention belongs to the field of pharmaceutical chemicals, relates to a preparation method of a quinolone carboxylic acid derivative or a phthalazinone carboxylic acid derivative, and particularly relates to a preparation method of a 7-substituted-3-quinolone carboxylic acid derivative or a 7-substituted-1,5-phthalazinone carboxylic acid derivative. The preparation method comprises the following steps: (1) in an organic solvent, carrying out coupling reaction on a boron chelate II and organic amine III in the presence of an organosilicon compound to obtain a compound IV; and (2) mixing the compound IV with hydrochloric acid, and then filtering and separating the precipitated compound I. Compared with conventional methods, the preparation method provided by the invention has the advantages that the conditions are milder, the hydrolysis of the substrate quinoline carboxylic acid boric acid ester can be reduced, and meanwhile, the influence of a byproduct HF on the product purity is avoided. The method is high in yield and high in purity; compared with the traditional alkali, the organic silicon is more suitable for industrial preparation of the 7-substituted-3-quinolone carboxylic acid derivative or the 7-substituted-1,5-phthalazinone carboxylic acid derivative.

Developing ciprofloxacin analogues against plant DNA gyrase: A novel herbicide mode of action

Ciprofloxacin has been shown to exhibit potent herbicidal activity through action against plant DNA gyrase, presenting a novel mode of action. Analogues of ciprofloxacin have been prepared with increased herbicidal activity and diminished antibacterial activity, compared to ciprofloxacin, as demonstrated using model systems.

An expeditious synthesis of quinolone antibacterials

A facile and rapid synthesis of ciprofloxacin under microwave irradiation is described. The product ciprofloxacin was isolated and the impurity was characterized as the product of substitution of fluorine instead of chlorine in acid 1. Similarly norfloxacin was synthesized.