74121-92-9

Basic information

• Product Name: (±)-2-isopropoxy-1,2-diphenylethan-1-ol
• Synonyms: (±)-2-isopropoxy-1,2-diphenylethan-1-ol
• CAS NO: 74121-92-9
• Molecular Weight: 256.345
• Mol File: 74121-92-9.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: (±)-2-isopropoxy-1,2-diphenylethan-1-ol(CAS DataBase Reference)
• NIST Chemistry Reference: (±)-2-isopropoxy-1,2-diphenylethan-1-ol(74121-92-9)
• EPA Substance Registry System: (±)-2-isopropoxy-1,2-diphenylethan-1-ol(74121-92-9)

Safety Data

• Hazardous Substances Data: 74121-92-9(Hazardous Substances Data)

Upstream product

• 6652-28-4 benzoin isopropyl ether 
• 1689-71-0 2,3-diphenyloxirane 
• 67-63-0 isopropyl alcohol 
• 492-70-6 1,2-diphenyl-1,2-ethanediol 
• 100-52-7 benzaldehyde 

Relevant articles and documents

Isothiourea-Catalysed Sequential Kinetic Resolution of Acyclic (±)-1,2-Diols

The isothiourea-catalysed acylative kinetic resolution of a range of acyclic (±)-1,2-diols using 1 molpercent of catalyst under operationally simple conditions is reported. Significantly, the bifunctional nature of (±)-1,2-diols was exploited in a sequential double kinetic resolution, in which both kinetic resolutions operate synergistically to provide access to highly enantioenriched products. The principles that underpin this process are discussed, and selectivity factors for the individual kinetic resolution steps are reported in a model system.

Highly diastereoselective catalytic Meerwein-Ponndorf-Verley reductions

Very practical synthesis of ephedrine analogues in high yields and enantiopurity was realized by a highly diastereoselective Meerwein-Ponndorf- Verley (MPV) reduction of protected α-amino aromatic ketones using catalytic aluminum isopropoxide. The high anti selectivity resulted from the chelation of the nitrogen anion to the aluminum. In contrast, high syn selectivity was obtained with α-alkoxy ketones and other compounds via Felkin-Ahn control.