743460-20-0

Basic information

• Product Name: THRX-198321
• Synonyms: THRX-198321
• CAS NO: 743460-20-0
• Molecular Weight: 640.823
• Mol File: 743460-20-0.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: THRX-198321(CAS DataBase Reference)
• NIST Chemistry Reference: THRX-198321(743460-20-0)
• EPA Substance Registry System: THRX-198321(743460-20-0)

Safety Data

• Hazardous Substances Data: 743460-20-0(Hazardous Substances Data)

Upstream product

• 743460-27-7 biphenyl-2-yl-carbamic acid 1-{9-[(R)-2-(tert-butyldimethylsilanyloxy)-2-(8-hydroxy-2-oxo-1,2-dihydroquinolin-5-yl)ethylamino]nonyl}piperidin-4-yl ester 
• 171723-80-1 1-benzyl-4-piperidylbiphenyl-2-ylcarbamate 
• 171722-92-2 4-piperidyl N-(2-biphenyl)carbamate 
• 17337-13-2 [1,1'-biphenyl]-2-yl-isocyanate 
• 4727-72-4 1-benzyl-4-hydroxypiperidine 
• 743460-24-4 Biphenyl-2-ylcarbamic Acid 1-(9-Oxononyl)piperidin-4-yl Ester 
• 852291-44-2 biphenyl-2-ylcarbamic acid 1-(9-hydroxynonyl)piperidin-4-yl ester 
• 73602-61-6 triethylamine tris(hydrogen fluoride) 

Downstream Products

• 743460-28-8 biphenyl-2-ylcarbamic acid 1-{9-[(R)-2-hydroxy-2-(8-hydroxy-2-oxo-1,2-dihydroquinolin-5-yl)ethylamino]nonyl}piperidin-4-yl ester naphthalene-1,5-disulfonic acid salt 

Relevant articles and documents

Discovery of muscarinic acetylcholine receptor antagonist and beta 2 adrenoceptor agonist (MABA) dual pharmacology molecules

We sought to design dual pharmacology bronchodilators targeting both the M3 muscarinic acetylcholine and beta-2 adrenergic (β2) receptors by applying our multivalent approach to drug discovery. Herein, we describe our initial discovery and the SAR of the first such compounds with matched potencies at both receptors.

Biphenyl derivatives

This invention provides biphenyl derivatives of formula I: wherein R1, R2, R3, R4, R5, R6, R7, W, a, b and c are as defined in the specification, or a pharmaceutically acceptable salt or solvate or stereoisomer thereof. The biphenyl derivatives of this invention possess both β2 adrenergic receptor agonist and muscarinic receptor antagonist activity and therefore, such biphenyl derivatives are useful for treating pulmonary disorders, such as chronic obstructive pulmonary disease and asthma.