171722-92-2 Usage
Description
Piperidin-4-yl [1,1'-biphenyl]-2-ylcarbamate, also known as 4-Piperidyl N-(2-biphenylyl)carbamate, is an organic compound that serves as a crucial intermediate in the synthesis of pharmaceutical compounds. It is characterized by its structural composition, which includes a piperidine ring and a biphenyl group connected through a carbamate linkage. This unique structure endows it with specific properties that make it valuable in the development of certain medications.
Uses
Used in Pharmaceutical Synthesis:
Piperidin-4-yl [1,1'-biphenyl]-2-ylcarbamate is used as an intermediate in the synthesis of Des-4''(methylpiperidine-4-carboxamide)-4''-hydroxymethyl Revefenacin (D119860), which is an impurity of Revefenacin (R279600). Revefenacin is a pharmaceutical drug utilized for the treatment of chronic obstructive pulmonary diseases (COPD). The compound plays a significant role in the development of effective treatments for respiratory conditions by contributing to the synthesis of the active pharmaceutical ingredient.
In the pharmaceutical industry, piperidin-4-yl [1,1'-biphenyl]-2-ylcarbamate is used as a key building block for the creation of Revefenacin, a drug that targets the management and treatment of chronic obstructive pulmonary diseases. Its application in this context is crucial, as it helps in the development of medications that can improve the quality of life for patients suffering from these respiratory conditions.
Physical Form
Solid
Check Digit Verification of cas no
The CAS Registry Mumber 171722-92-2 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,7,1,7,2 and 2 respectively; the second part has 2 digits, 9 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 171722-92:
(8*1)+(7*7)+(6*1)+(5*7)+(4*2)+(3*2)+(2*9)+(1*2)=132
132 % 10 = 2
So 171722-92-2 is a valid CAS Registry Number.
InChI:InChI=1/C18H20N2O2/c21-18(22-15-10-12-19-13-11-15)20-17-9-5-4-8-16(17)14-6-2-1-3-7-14/h1-9,15,19H,10-13H2,(H,20,21)
171722-92-2Relevant articles and documents
GSK961081 and its intermediate synthesis method
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, (2019/02/21)
The invention relates to a new method for preparing a medicine GSK961081 and an intermediate thereof. Compared with an existing synthetic method, the new method not only avoids the use of a hypertoxic isocyanate reagent, but also is simple in synthetic ro
PROCESS FOR PREPARING A BIPHENYL-2-YLCARBAMIC ACID
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Page/Page column 8-9, (2012/02/01)
The invention provides a process of preparing an intermediate useful in the synthesis of biphenyl-2-ylcarbamic acid 1-(2-{[4-(4-carbamoylpiperidin-1-ylmethyl)benzoyl]methylamino}ethyl)piperidin-4-yl ester, and a process of preparing a crystalline freebase of the ester.
Crystalline forms of a biphenyl compound
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Page/Page column 15, (2010/11/30)
The invention provides crystalline forms of biphenyl-2-ylcarbamic acid 1-[2-({3-[2-(4-hydroxybenzylamino)ethylcarbamoyl]benzoyl}methylamino)ethyl]piperidin-4-yl ester, and pharmaceutically acceptable solvates thereof. The crystalline form can be a freebase (Form I or II), a salt such as a hemiedisylate salt or a heminapadisylate salt, or a solvate of a salt such as a heminapadisylate methanolate or a heminapadisylate ethanolate. The invention also provides pharmaceutical compositions comprising these crystalline compounds or prepared using these compounds; processes and intermediates for preparing the crystalline compounds; and methods of using these compounds to treat a pulmonary disorder.
