745078-83-5

Basic information

• Product Name: Ethyl 5-(3-((tert-butoxycarbonyl)amino)phenyl)isoxazole-3-carboxylate
• Synonyms: Ethyl 5-(3-((tert-butoxycarbonyl)amino)phenyl)isoxazole-3-carboxylate;5-(3-tert-butoxycarbonylamino-phenyl)-isoxazole-3-carboxylic acid ethyl ester;5-(3-tert-butoxycarbonylamino-phenyl)-isoxazole-3-carboxy…;methyl 5-(3-((tert-butoxycarbonyl)amino)phenyl)isoxazole-3-carboxylate
• CAS NO: 745078-83-5
• Molecular Formula: C₁₇H₂₀N₂O₅
• Molecular Weight: 332.3511
• Mol File: 745078-83-5.mol
• Article Data: 6

Chemical Properties

• Appearance: /
• CAS DataBase Reference: Ethyl 5-(3-((tert-butoxycarbonyl)amino)phenyl)isoxazole-3-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: Ethyl 5-(3-((tert-butoxycarbonyl)amino)phenyl)isoxazole-3-carboxylate(745078-83-5)
• EPA Substance Registry System: Ethyl 5-(3-((tert-butoxycarbonyl)amino)phenyl)isoxazole-3-carboxylate(745078-83-5)

Safety Data

• Hazardous Substances Data: 745078-83-5(Hazardous Substances Data)

Usage

General Description

Ethyl 5-(3-((tert-butoxycarbonyl)amino)phenyl)isoxazole-3-carboxylate is a chemical compound with the molecular formula C18H20N2O6. It is a derivative of isoxazole and has a carboxylate ester functional group. The compound contains an ethyl group, a phenyl ring with a tert-butoxycarbonyl group attached, and an isoxazole ring with a carboxylate ester group. Ethyl 5-(3-((tert-butoxycarbonyl)amino)phenyl)isoxazole-3-carboxylate is commonly used in the synthesis of pharmaceuticals and as a research chemical. It may have potential applications in the development of new drugs and biologically active compounds. However, it is important to handle and use this chemical with caution, following proper safety protocols and regulations.

Upstream product

• 14337-43-0 ethyl 2-chloro-2-(hydroxyimino)acetate 
• 185619-66-3 (3-ethynyl-phenyl)-carbamic acid tert-butyl ester 
• 95080-93-6 ethyl chlorooximidoacetate 
• 54060-30-9 3-acetylenephenylamine 
• 24424-99-5 di-tert-butyl dicarbonate 

Downstream Products

• 745078-84-6 5-(3-amino-phenyl)-isoxazole-3-carboxylic acid ethyl ester 

Relevant articles and documents

HDAC INHIBITORS AND THERAPEUTIC METHODS USING THE SAME

Histone deacetylases inhibitors (HDACIs) and compositions containing the same are disclosed. Methods of treating diseases and conditions wherein inhibition of HDAC provides a benefit, like a cancer, a neurodegenerative disorder, a peripheral neuropathy, a

Use of the Nitrile Oxide Cycloaddition (NOC) reaction for molecular probe generation: A new class of enzyme selective histone deacetylase inhibitors (HDACIs) showing picomolar activity at HDAC6

A series of hydroxamate based HDAC inhibitors containing a phenylisoxazole as the CAP group has been synthesized using nitrile oxide cycloaddition chemistry. An HDAC6 selective inhibitor having a potency of ～2 picomolar was identified. Some of the compounds were examined for their ability to block pancreatic cancer cell growth and found to be about 10-fold more potent than SAHA. This research provides valuable, new molecular probes for use in exploring HDAC biology.

Protein-tyrosine phosphatase inhibitors and uses thereof

The present invention is directed to compounds of formula (I), or a pharmaceutically suitable salt or prodrug thereof, which are useful for the selective inhibition of protein tyrosine phosphatase-1B (PTP1B), and are useful for the treatment of disorders caused by overexpressed or altered protein tyrosine phosphatase 1B.