74516-69-1

Basic information

• Product Name: (4alpha,8alpha)-12,13-epoxytrichothec-9-ene-4,8,15-triol
• Synonyms: (4beta,8alpha)-12,13-epoxytrichothec-9-ene-4,8,15-triol; trichothec-9-ene-4,8,15-triol, 12,13-epoxy-, (4beta,8alpha)-
• CAS NO: 74516-69-1
• Molecular Formula: C₁₅H₂₂O₅
• Molecular Weight: 282.3322
• Mol File: 74516-69-1.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 477°C at 760 mmHg
• Flash Point: 242.3°C
• Density: 1.39g/cm³
• Vapor Pressure: 4.21E-11mmHg at 25°C
• Refractive Index: 1.619
• CAS DataBase Reference: (4alpha,8alpha)-12,13-epoxytrichothec-9-ene-4,8,15-triol(CAS DataBase Reference)
• NIST Chemistry Reference: (4alpha,8alpha)-12,13-epoxytrichothec-9-ene-4,8,15-triol(74516-69-1)
• EPA Substance Registry System: (4alpha,8alpha)-12,13-epoxytrichothec-9-ene-4,8,15-triol(74516-69-1)

Safety Data

• Hazardous Substances Data: 74516-69-1(Hazardous Substances Data)

Upstream product

• 77101-87-2 verrucarin L 
• 77101-88-3 verrucarin L acetate 
• 80326-33-6 roridin K acetate 
• 74516-62-4 8α-hydroxyverrucarin A 
• 74526-04-8 16-oxoverrucarin A 
• 3148-09-2 verrucarin A 
• 74516-64-6 16-hydroxyverrucarin A 
• 74608-63-2 8β-hydroxyverrucarin A 
• 99127-69-2 4β,15-Diacetoxy-8α-<(3-methylbutyryl)oxy>-12,13-epoxytrichothec-9-ene 
• 21259-20-1 T-2 toxin 
• 118143-05-8 4β,15-Diacetoxy-3-<(1-imidazolylthiocarbonyl)oxy>-8α-<(3-methylbutyryl)oxy>-12,13-epoxytrichothec-9-ene 

Relevant articles and documents

Structure-Activity Studies of Trichothecenes: Cytotoxicity of Analogues and Reaction Products Derived from T-2 Toxine and Neosolaniol

Forty-two analogues and reaction products derived from T-2 toxin or neosolaniol were assayed for their cytotoxicity to cultured mouse lymphoma cells.Structure-activity relationships confirmed the stereospecific nature of the cytotoxic action of T-2.Cytoto

Antileukemic Compounds Derived from the Chemical Modification of Macrocyclic Trichothecenes. 1. Derivatives of Verrucarin A

Verrucarin A (2) was epoxidized to give the β-9,10-epoxide 7 (major product) and α-9,10-epoxide 9 (minor product).The β-epoxide 7 and its acetate 8 exhibit high in vivo antileukemic activity against P-388 mouse leukemia, whereas 2 and 9 are inactive.Epoxidation of verrucarin B (3) and roridin A (1) to their respective β-9,10-epoxides (11 and 12, respectively) also yields compounds with substantially increased activity.Allylic alcohols derived from 2, α-C8 (20), β-C8 (14), and C16 (15), were synthesized and tested; only 15 exhibited substantial in vivo activity.