745820-44-4

Basic information

• Product Name: 4-(4-(methylsulfinyl)phenyl)-3-phenylfuran-2(5H)-one
• Synonyms: 4-(4-(methylsulfinyl)phenyl)-3-phenylfuran-2(5H)-one
• CAS NO: 745820-44-4
• Molecular Weight: 298.362
• Mol File: 745820-44-4.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: 4-(4-(methylsulfinyl)phenyl)-3-phenylfuran-2(5H)-one(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(4-(methylsulfinyl)phenyl)-3-phenylfuran-2(5H)-one(745820-44-4)
• EPA Substance Registry System: 4-(4-(methylsulfinyl)phenyl)-3-phenylfuran-2(5H)-one(745820-44-4)

Safety Data

• Hazardous Substances Data: 745820-44-4(Hazardous Substances Data)

Upstream product

• 103-82-2 phenylacetic acid 
• 329328-49-6 3-bromo-4-(4'-methylthiophenyl)-5H-furan-2-one 
• 98546-51-1 (4-thiomethoxyphenyl)boronic acid 
• 42445-46-5 2-bromo-1-(4-methylsulfanyl-phenyl)-ethanone 
• 162012-30-8 4-(4-(methylthio)phenyl)-3-phenylfuran-2(5H)-one 

Downstream Products

• 866336-10-9 thiobutyric acid S-[4-(5-oxo-4-phenyl-2,5-dihydro-furan-3-yl)-phenyl] ester 

Relevant articles and documents

Sulfoxide and sulfone compounds, as well as selective synthesis method and application thereof

The invention discloses a method for selectively synthesizing a sulfoxide compound shown as a formula (II) and a sulfone compound shown as a formula (III). In a reaction solvent, thioether (I) is usedas a reaction raw material and oxygen as an oxidation reagent, under the catalytic action of visible light and a photosensitive reagent; under the assistance of an additive, when a large-polarity proton-containing additive such as an acid and an alcohol or a solvent or an additive with excellent electron donating ability is used, a sulfoxide compound (II) is selectively generated; and when a small-polarity aprotic additive or a solvent is used, a sulfone compound (III) is selectively generated. The synthesis method has the advantages of easily available and cheap raw materials, simple reaction operation, mild reaction conditions, high yield and excellent functional group tolerance. According to the invention, synthesis and modification of some medicines are realized, and an efficient method for selectively constructing sulfoxide and sulfone compounds is provided for medicinal chemistry research.

Racemic and chiral sulfoxides as potential prodrugs of the COX-2 inhibitors Vioxx and Arcoxia

The preparation of the sulfoxide analogues 2 and 4, and their enantiomeric pure forms is discussed as well as their potential to act as prodrugs to the potent and selective sulfone-containing COX-2 inhibitors rofecoxib and etoricoxib. Sulfoxides 2 and 4 w

RADIOLABELED ARYLSULFONYL COMPOUNDS AND USES THEREOF

The present invention relates to Radiolabeled Arylsulfonyl Compounds and methods of use thereof as imaging agents for the COX-2 enzyme using positron-emission tomograpy (PET). Methods of making the Radiolabeled Arylsulfonyl Compounds and pharmaceutical co