162012-30-8Relevant articles and documents
PURIFIED FORMS OF ROFECOXIB, METHODS OF MANUFACTURE AND USE
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, (2020/06/10)
The subject matter disclosed herein relates to rofecoxib, also known as TRM-201 or RXB-201, its method of manufacture, and use. In certain aspects, the highly pure or substantially pure rofecoxib as provided herein has a favorable purity profile and is the active ingredient in a pharmaceutical composition that is administered to treat or prevent a number of conditions, including pain associated with a condition caused by a bleeding disorder.
Racemic and chiral sulfoxides as potential prodrugs of the COX-2 inhibitors Vioxx and Arcoxia
Caturla, Francisco,Amat, Merce,Reinoso, Raquel F.,Cordoba, Monica,Warrellow, Graham
, p. 3209 - 3212 (2007/10/03)
The preparation of the sulfoxide analogues 2 and 4, and their enantiomeric pure forms is discussed as well as their potential to act as prodrugs to the potent and selective sulfone-containing COX-2 inhibitors rofecoxib and etoricoxib. Sulfoxides 2 and 4 w
Preparation of aryl-substituted butenolides using mucohalic acids
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Page/Page column 8-9, (2008/06/13)
Methods and materials for preparing 3-aryl-2-buten-4-olides and 2,3-bisaryl-2-buten-4-olides are disclosed. The methods include reacting a mucohalic acid with a reducing agent to give a 2,3-dihalo-2-buten-4-olide, which undergoes at least one Pd catalyzed cross-coupling reaction with an arylboronic acid.