7464-91-7

Basic information

• Product Name: 2-FORMYL-5-NITROBENZOIC ACID
• Synonyms: Benzoic acid,2-formyl-5-nitro-
• CAS NO: 7464-91-7
• Molecular Formula: C₈H₅NO₅
• Molecular Weight: 195.129
• Mol File: 7464-91-7.mol
• Article Data: 8

Chemical Properties

• Boiling Point: 424.8 °C at 760 mmHg
• Flash Point: 193.3 °C
• Appearance: /
• Density: 1.555 g/cm³
• Vapor Pressure: 5.65E-08mmHg at 25°C
• Refractive Index: 1.662
• CAS DataBase Reference: 2-FORMYL-5-NITROBENZOIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 2-FORMYL-5-NITROBENZOIC ACID(7464-91-7)
• EPA Substance Registry System: 2-FORMYL-5-NITROBENZOIC ACID(7464-91-7)

Safety Data

• Hazardous Substances Data: 7464-91-7(Hazardous Substances Data)

Usage

General Description

2-Formyl-5-nitrobenzoic acid, also known as 5-nitrosalicylaldehyde, is a chemical compound with the molecular formula C8H5NO5. It is a yellow crystalline solid that is commonly used in the production of pharmaceuticals and dyes. 2-FORMYL-5-NITROBENZOIC ACID is known for its ability to participate in numerous chemical reactions, including condensation, oxidation, and reduction. It is also utilized in the synthesis of various organic compounds due to its versatile chemical reactivity. Additionally, 2-formyl-5-nitrobenzoic acid has been investigated for its potential antibacterial and antifungal properties, making it a compound of interest in the field of medicinal chemistry.

InChI:InChI=1/C8H5NO5/c10-4-5-1-2-6(9(13)14)3-7(5)8(11)12/h1-4H,(H,11,12)

Upstream product

• 7664-93-9 sulfuric acid 
• 119-67-5 o-carboxybenzaldehyde 
• 89891-73-6 6-nitro-3-bromo-3H-isobenzofuran-1-one 
• 68-12-2 N,N-dimethyl-formamide 
• 943-14-6 2-bromo-5-nitrobenzoic acid 
• 87-41-2 2-benzofuran-1(3H)-one 
• 872823-31-9 6-nitro-2-phenyl-inden-1-one 
• 610-93-5 6-nitrophthalide 

Downstream Products

• 610-27-5 4-nitrophthalic acid 
• 754191-79-2 2-bis(5-methyl-2-furyl)methyl-5-nitrobenzoic acid 
• 754191-80-5 2-bis(5-ethyl-2-furyl)methyl-5-nitrobenzoic acid 
• 899366-23-5 5-nitro-2-(4-oxo-1,4-dihydro-2H-3,1-benzoxazin-2-yl)benzoic acid 
• 92160-71-9 2-(1H-benzoimidazol-2-yl)-5-nitro-benzoic acid 
• 142314-69-0 methyl 2-formyl-5-nitrobenzoate 
• 728885-39-0 C₂₇H₁₈N₂O₄ 
• 4512-21-4 2-(1,1-dioxo-1,2(4)-dihydro-1λ⁶-benzo[1,2,4]thiadiazin-3-yl)-5-nitro-benzoic acid 
• 103286-06-2 7-nitro-2-phenyl-1(2H)-phthalazinone 
• 859299-84-6 7-nitro-1-phenoxy-phthalazine 
• 84716-03-0 C₂₆H₂₄N₂O₃ 
• 58273-90-8 1-benzyl-3,3-dimetyl-6'-nitrospiro(<2H-1>-benzopyran-2',2-indoline) 

Relevant articles and documents

Synthesis of chiral isoindolinones via asymmetric propargylation/lactamization cascade

A Zn-mediated propargylation/lactamization cascade reaction with chiral 2-formylbenzoate derived N-tert-butanesulfinyl imines was realized, which provided a practical and efficient method for the synthesis of chiral isoindolinones. High diastereoselectivities (up to 97:3 dr) and good reaction yields were observed for most examined cases.

A general catalytic route to isoindolinones and tetrahydroisoquinolines: Application in the synthesis of (±)-crispine A

An unprecedented highly efficient Lewis acid catalyzed one-pot cascade has been demonstrated as a general catalytic system for the synthesis of diversely substituted isoindolinones and tetrahydroisoquinolines. The cascade effects one C-C and two C-N bond-

A synthetic route to chiral C(3)-functionalized phthalides via a Ag(I)-catalyzed allylation/transesterification sequence

A Ag(I)-catalyzed synthesis of chiral C(3)-substituted phthalides (8a-f) via a Sakurai-Hosomi allylation/transesterification reaction is described (ee ≤86%). A notable feature of this reaction is that it utilizes ortho-substituted aldehydes, which are a class of compounds that generally afford poor levels of stereoinduction when applying most known catalytic asymmetric allylation approaches. It was also found that elongation of the n-alkyl chain length (R1, up to n=6; R2=H) of the starting alkyl 2-formylbenzoates (7g-i) improved the enantiomeric excess (ee) of the product.