74704-94-2

Basic information

• Product Name: 2,6-dimethyl-N-[(5-methylisoxazol-3-yl)methyl]aniline
• CAS NO: 74704-94-2
• Molecular Formula: C₁₃H₁₆N₂O
• Molecular Weight: 216.2789
• Mol File: 74704-94-2.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 365.6°C at 760 mmHg
• Flash Point: 174.9°C
• Density: 1.112g/cm³
• Vapor Pressure: 1.55E-05mmHg at 25°C
• Refractive Index: 1.585
• CAS DataBase Reference: 2,6-dimethyl-N-[(5-methylisoxazol-3-yl)methyl]aniline(CAS DataBase Reference)
• NIST Chemistry Reference: 2,6-dimethyl-N-[(5-methylisoxazol-3-yl)methyl]aniline(74704-94-2)
• EPA Substance Registry System: 2,6-dimethyl-N-[(5-methylisoxazol-3-yl)methyl]aniline(74704-94-2)

Safety Data

• Hazardous Substances Data: 74704-94-2(Hazardous Substances Data)

Usage

Molecular weight

268.36 g/mol

Structure

A central aniline group attached to a methylisoxazolylmethyl group, with two methyl groups attached to the aniline ring.

Usage

Commonly used in the synthesis of pharmaceuticals, organic dyes, and other fine chemicals. Potential applications in medicinal chemistry and drug design.

Precautions

Potential toxicity and environmental impact, should be handled with care.

Upstream product

• 39499-34-8 5-methyl-3-isoxazolyl chloride 
• 35166-37-1 3-chloromethyl-5-methylisoxazole 
• 87-62-7 2,6-dimethylaniline 
• 130402-91-4 D₂₆₂₄ 

Relevant articles and documents

New N-aryl isoxazolecarboxamides and N-isoxazolylbenzamides as anticonvulsant agents

We prepared a series of N-aryl isoxazolecarboxamide, N-isoxazolylbenzamide compounds and derivatives and studied their anticonvulsant action in MES and MMS tests. Some of these reveal considerable activity, especially with respect to MES test. The disubstitution in the 2.6-position on the phenyl ring by two methyl groups would appear to be of primary importance for the activity. The amide bridge between the phenyl and isoxazolic rings, whether of the anilide or benzamide type, seems to show similar anticonvulsant behavior. We have selected the derivatives 8 (N-(2.6-dimethylphenyl)-5-methyl-3-isoxazolecarboxamide, 12 (N-(2.6-dimethylphenyl)-5-hydroxymethyl-3-isoxazolecarboxamide) and 51 (N-(5-methyl-3-isoxazolyl)-2.6-dimethylbenzamide) which are presently being studied in more extended pharmacological tests.