7471-12-7Relevant articles and documents
Two new Cu(II) dipeptide complexes based on 5-methyl-2-(2′-pyridyl)benzimidazole as potential antimicrobial and anticancer drugs: Special exploration of their possible anticancer mechanism
Qi, Yong-Yu,Gan, Qian,Liu, Ya-Xian,Xiong, Ya-Hong,Mao, Zong-Wan,Le, Xue-Yi
, p. 220 - 232 (2018)
In the search for more effective anticancer drugs with less toxic side effects, dipeptides were introduced into the Cu(II) complex of 5-methyl-2-(2′-pyridyl)benzimidazole (HPBM). Analytical and spectroscopic techniques were employed to thoroughly characterize complexes [Cu(Gly-gly)(HPBM)(H2O)]ClO4·0.5H2O (1) and [Cu(Gly-L-leu)(HPBM)(H2O)]ClO4 (2) (where Gly-gly = Glycyl-glycine anion, Gly-L-leu = Glycyl-l-leucine anion). The solution stability studies performed by ultraviolet–visible (UV–Vis) spectroscopy confirmed the stability of the complexes in the buffer solutions. The DNA binding affinity was evaluated using multi-spectroscopy, viscosity measurement and molecular docking methods and further quantified by Kb and Kapp values, revealing an intercalative mode. Moreover, gel electrophoresis analysis revealed that the complexes could damage CT DNA through a hydroxyl radical pathway in the presence of ascorbic acid. All the complexes displayed favorable antimicrobial and cytotoxic activities toward the tested microorganisms (Bacillus subtilis, Staphylococcus aureus, Escherichia coli and Pseudomonas aeruginosa) and cancer cells (A549, HeLa and PC-3). Most importantly, the possible anticancer mechanism of the complexes was explored by determining the cells morphological changes, intracellular reactive oxygen species (ROS) levels, location in mitochondria, mitochondrial membrane potentials and the expression of Bcl-2 family proteins. The results showed that the complexes could induce apoptosis in HeLa cells through an ROS-mediated mitochondrial dysfunction pathway, which was accompanied by the regulation of Bcl-2 family proteins.
Amphiphilic Dendrimer as Reverse Micelle: Synthesis, Characterization and Application as Homogeneous Organocatalyst
Sherly mole,George, Smitha,Shebitha,Kannan,Mathew, Suseela,Asha,Sreekumar
, (2019/10/14)
The core and surface terminal groups are the two main catalytic sites in a dendrimer. In most of the reported examples, the catalytic sites in dendritic catalysis are the surface terminal functional groups. This perspective article concerned with the dend
Titanium, zirconium and vanadium complexes of 2-(benzimidazolyl, benzothiazolyl, and benzoxazolyl) pyridine as catalyst precursors for ethylene polymerization
Elagab, Hamdi Ali,Alt, Helmut G.
, p. 266 - 275 (2015/06/02)
Dissymmetric chelating complexes of Ti, Zr and V with 2-(benzimidazolyl, benzothiazolyl, and benzoxazolyl) pyridine ligands were synthesized and characterized. After activation with methylalumoxane (MAO) in solution, these complexes could be applied as ethylene polymerization catalysts. Their activities depend on the metal and the substituents at the pyridine ring and the heterocycle. Structure-property-relationship studies revealed that the titanium and vanadium catalyst systems showed higher polymerization activities than the zirconium analogues. The benzoxazolyl moiety containing vanadium complex 29, with a methyl substituent in the 6-membered ring in meta position to the nitrogen atom in the 5-membered ring, and an unsubstituted pyridine ring showed the highest activity (1154.8 kg PE/mol cat h). The produced polyethylenes exhibited high molecular weights and broad molecular weight distributions. Obviously different active sites are generated in the course of these polymerization reactions.
