74822-65-4

Basic information

• Product Name: (R)-(+)-1,2-diamino-3-phenylpropane dihydrochloride
• CAS NO: 74822-65-4
• Molecular Weight: 223.145
• Mol File: 74822-65-4.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: (R)-(+)-1,2-diamino-3-phenylpropane dihydrochloride(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-(+)-1,2-diamino-3-phenylpropane dihydrochloride(74822-65-4)
• EPA Substance Registry System: (R)-(+)-1,2-diamino-3-phenylpropane dihydrochloride(74822-65-4)

Safety Data

• Hazardous Substances Data: 74822-65-4(Hazardous Substances Data)

Upstream product

• 5241-58-7 D-Phenylalaninamide 
• 21685-51-8 D-phenylalanine methyl ester 
• 1374035-95-6 C₂₇H₃₂N₂O₂ 
• 134557-74-7 tert-butyl [(2S)-1-azido-3-phenylpropan-2-yl]carbamate 
• 126301-19-7 (2S)-2-[(tert-butoxycarbonyl)amino]-3-phenylpropyl methanesulfonate 
• 66605-57-0 (S)-N-tert-butoxycarbonyl-2-amino-3-phenylpropanol 
• 146552-72-9 (S)-2-(t-butoxycarbonylamino)-3-phenylpropylamine 
• 5241-58-7 L-Phenylalanine amide 
• 93554-83-7 α-aminophenylpropiononitrile hydrochloride 

Downstream Products

• 85612-68-6 (R)-4-Benzyl-2-(3,4-bis-benzyloxy-benzyl)-4,5-dihydro-1H-imidazole 
• 85612-69-7 (S)-4-Benzyl-2-(3,4-bis-benzyloxy-benzyl)-4,5-dihydro-1H-imidazole 
• 74822-73-4 (R)-2,4-Dibenzyl-4,5-dihydro-1H-imidazole 
• 74822-74-5 (4S)-2,4-dibenzyl-4,5-dihydro-1H-imidazole 
• 89145-75-5 (4-Benzyl-4,5-dihydro-1H-imidazol-2-yl)-carbamic acid methyl ester 

Relevant articles and documents

SYNTHESIS OF ARYL CYCLOHEXANE CARBOXAMIDE DERIVATIVES USEFUL AS SENSATES IN CONSUMER PRODUCTS

Synthesis methods to produce a series of carboxamides built off of an (S)-2-amino acid backbone or an (R)-2-amino acid backbone, depending upon the desired diastereomer of the end product.

Process for the preparation of enantiomerically enriched compounds

1. Process for the preparation of enantiomerically enriched amino aldehydes and amino alcohols, wherein a corresponding enantiomerically enriched amino nitrile is subjected to hydrogenation in the presence of hydrogen, a hydrogenation catalyst, preferably a Pd-catalyst and a mineral acid. For the preparation of an amino aldehyde hydrogen preferably is present at a hydrogen-pressure between 0.1 and 2 MPa, in particular between 0.5 and 1 MPa. The amino aldehyde preferably is isolated in the form of a chemically and configurationally stable derivative. For the preparation of an amino alcohol, preferably at least during part of the hydrogenation hydrogen is present at a hydrogen-pressure between 2 and 10 MPa, in particular between 4 and 6 MPa. In a preferred embodiment the hydrogen-pressure initially is between 0,5 and 2 MPa and subsequently, after most of the nitrile starting material is converted, the hydrogen pressure is increased to a value between 2 and 10 MPa. The enantiomerically enriched nitrile starting material may a.o. be prepared by enzymatic resolution, classical resolution, resolution via preferential crystallization, diastereomeric synthesis, catalytic asymmetric synthesis or dehydratation of amino acid amides.

Optically Active Derivatives of Imidazolines. α-Adrenergic Blocking Properties

The synthesis and α-adrenergic blocking activity of a series of optically active 2,4-disubstituted imidazolines are presented.The substituted analogues of naphazoline, tolazoline, and clonidine possess moderate α-adrenergic blocking activity with -logKsu