74844-93-2

Basic information

• Product Name: METHYL N-BOC-L-PROLINE-3-ENE
• Synonyms: METHYL N-BOC-L-PROLINE-3-ENE ;(S)-2,5-Dihydro-pyrrole-1,2-dicarboxylic acid 1-tert-butyl ester 2-methyl ester;1-tert-butyl 2-Methyl 2,5-dihydro-1H-pyrrole-1,2-dicarboxylate;(S)-Boc-3,4-dehydro-pyrrolidine methyl ester;Boc-3,4-dehydro-L-proline methyl ester99%;Boc-3,4-dehydro-L-Pro-OMe;1-(1,1-dimethylethyl) 2-methyl ester 2,5-dihydro-1H-Pyrrole-1,2-dicarboxylic acid, (2S)-
• CAS NO: 74844-93-2
• Molecular Formula: C₁₁H₁₇NO₄
• Molecular Weight: 197.27406
• Mol File: 74844-93-2.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 287.334oC at 760 mmHg
• Flash Point: 127.575oC
• Appearance: /
• Density: 1.149g/cm3
• Vapor Pressure: 0.002mmHg at 25°C
• Refractive Index: 1.492
• Storage Temp.: Store at 0-5°C
• CAS DataBase Reference: METHYL N-BOC-L-PROLINE-3-ENE(CAS DataBase Reference)
• NIST Chemistry Reference: METHYL N-BOC-L-PROLINE-3-ENE(74844-93-2)
• EPA Substance Registry System: METHYL N-BOC-L-PROLINE-3-ENE(74844-93-2)

Safety Data

• Hazardous Substances Data: 74844-93-2(Hazardous Substances Data)

Usage

InChI:InChI=1/C11H17NO4/c1-11(2,3)16-10(14)12-7-5-6-8(12)9(13)15-4/h5-6,8H,7H2,1-4H3

Upstream product

• 74844-92-1 (2S,4R)-4-Methylsulfanylthiocarboxyoxy-pyrrolidine-1,2-dicarboxylic acid 1-tert-butyl ester 2-methyl ester 
• 189160-59-6 N-tert-butoxycarbonyl-trans-4-(trifluoromethylsulfonyloxy)-L-proline methyl ester 
• 84520-67-2 (2S,4R)-4-(methylsulfonyloxy)pyrrolidine-1,2-dicarboxylic acid 1-tert-butylester-2-methylester 
• 74844-91-0 1-tert-butyl 2-methyl (2S,4R)-4-hydroxy-1,2-pyrrolidinedicarboxylate 
• 220405-40-3 2,2-difluoro-1,3-dimethyl-imidazolidine 
• 38078-09-0 diethylamino-sulfur trifluoride 
• 40216-83-9 L-4-hydroxyproline methyl ester hydrochloride 

Downstream Products

• 135837-63-7 3,4-dehydro-1-(9-fluorenylmethoxycarbonyl)-L-proline 
• 210420-92-1 3,4-dehydroproline methyl ester 
• 90104-21-5 1-(tert-butoxycarbonyl)-2,3-dihydro-1H-pyrrole-2-carboxylic acid 
• 51154-06-4 (S)-2,5-dihydropyrrole-1,2-dicarboxylic acid 1-tert-butyl ester 
• 203866-13-1 (2S,4S)-1-(tert-butoxycarbonyl)-4-fluoropyrrolidine-2-carboxylic acid 
• 312699-33-5 C₅₉H₉₁N₇O₁₅ 
• 648934-08-1 (3aS,6S,6aS)-6-hydroxytetrahydro-2-oxa-1,4-diazapentalene-1,4-dicarboxylic acid 1-benzyl ester 4-tert-butyl ester 
• 648934-06-9 (2R)-(N'-benzyloxycarbonylaminooxymethyl)-6-oxa-3-azabicyclo[3.1.0]hexane-3-carboxylic acid tert-butyl ester 
• 648934-02-5 (S)-(N'-benzyloxycarbonylaminooxymethyl)-2,5-dihydropyrrole-1-carboxylic acid 1-tert-butyl ester 

Relevant articles and documents

Synthetic Marine Sponge Collagen by Late-Stage Dihydroxylation

Based on the observation that an increased substrate size is paralleled by an enhanced diastereoselectivity, a late-stage dihydroxylation protocol toward the 21mer CMP (collagen model peptide) Ac-(Pro-Hyp-Gly)3-Pro-Dyp-Gly-(Pro-Hyp-Gly)3-NH2 is presented. C3 and C4 hydroxylation have a converse effect on the triple-helical stability of collagen. Their combined influence on the melting temperature was studied by NMR spectroscopy.

METHOD FOR PRODUCING FLUORINATED PROLINE DERIVATIVE

Disclosed is a method for efficiently producing a high-purity fluorinated proline derivative with high yield. Specifically disclosed is a method for producing a compound represented by the general formula (2) below wherein a compound represented by the formula (1) below is reacted with a fluorination agent, and then chlorine, bromine, iodine, hypochlorous acid, hypochlorite, hypobromous acid, hypobromite or N-halogenosuccinimide is caused to act on the reaction product obtained by the preceding reaction and containing the compound represented by the general formula (2) below and a by-product for chemically changing the by-product. (1) (In the formula (1), R1 represents an unsubstituted or substituted alkyl group having 1-6 carbon atoms or the like; R2 represents an unsubstituted or substituted alkyl group having 1-6 carbon atoms or the like; and R3 represents a hydroxyl group or the like.) (2) (In the formula (2), R1 and R2 are as defined above.)

Direktes Verfahren zur Synthese von N-Boc-L-3,4-Didehydroprolin

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