74960-43-3

Basic information

• Product Name: methyl 3-methyl-2-phenylquinoline-4-carboxylate
• CAS NO: 74960-43-3
• Molecular Formula: C₁₈H₁₅NO₂
• Molecular Weight: 277.3172
• Mol File: 74960-43-3.mol
• Article Data: 7

Chemical Properties

• Boiling Point: 418.6°C at 760 mmHg
• Flash Point: 206.9°C
• Density: 1.173g/cm³
• Vapor Pressure: 3.24E-07mmHg at 25°C
• Refractive Index: 1.623
• CAS DataBase Reference: methyl 3-methyl-2-phenylquinoline-4-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: methyl 3-methyl-2-phenylquinoline-4-carboxylate(74960-43-3)
• EPA Substance Registry System: methyl 3-methyl-2-phenylquinoline-4-carboxylate(74960-43-3)

Safety Data

• Hazardous Substances Data: 74960-43-3(Hazardous Substances Data)

Upstream product

• 174636-71-6 3-methyl-2-phenylquinoline-4-carbonyl chloride 
• 79-37-8 oxalyl dichloride 
• 43071-45-0 3-methyl-2-phenylquinoline-4-carboxylic acid 
• 18107-18-1 diazomethyl-trimethyl-silane 
• 93-55-0 1-phenyl-propan-1-one 
• 91-56-5 indole-2,3-dione 
• 74960-44-4 2-Ethyl-3-methyl-quinoline-4-carboxylic acid methyl ester 
• 63123-82-0 methyl 2-ethyl-3-methylquinoline-4-carboxylate 1-oxide 
• 74960-58-0 2-ethyl-3-methylquinoline-4-carboxylic acid 
• 67-56-1 methanol 
• 74-88-4 methyl iodide 
• 74960-57-9 6-Ethyl-8-methyl-7-oxa-5-aza-benzocycloheptene-9-carboxylic acid methyl ester 
• 77-78-1 dimethyl sulfate 

Downstream Products

• 224633-12-9 3-(dimethylaminomethyl)-2-phenylquinoline-4-carboxylic cid 
• 174636-59-0 3-[(dimethylamino)methyl]-2-phenyl-N-[(1S)-1-phenylpropyl]quinoline-4-carboxamide 
• 345234-90-4 3-dimethylaminomethyl-2-phenyl-quinoline-4-carboxylic acid methyl ester 
• 791763-12-7 3-morpholin-4-ylmethyl-2-phenyl-quinoline-4-carboxylic acid 
• 345235-11-2 3-morpholin-4-ylmethyl-2-phenyl-quinoline-4-carboxylic acid methyl ester 
• 345235-07-6 2-phenyl-3-piperidin-1-ylmethyl-quinoline-4-carboxylic acid methyl ester 
• 270574-08-8 3-(4-isopropyl-piperazin-1-ylmethyl)-2-phenyl-quinoline-4-carboxylic acid methyl ester 
• 746637-40-1 3-(4-(1-methylethyl)-piperazin-1-ylmethyl)-2-phenyl-quinoline-4-carboxylic acid 
• 345235-12-3 3-(4-isobutyryl-piperazin-1-ylmethyl)-2-phenyl-quinoline-4-carboxylic acid methyl ester 
• 345235-10-1 3-(4-morpholin-4-yl-piperidin-1-ylmethyl)-2-phenyl-quinoline-4-carboxylic acid methyl ester 
• 270574-03-3 3-[1,4']Bipiperidinyl-1'-ylmethyl-2-phenyl-quinoline-4-Carboxylic Acid Methyl Ester 
• 345235-08-7 3-(4-cyclohexyl-piperazin-1-ylmethyl)-2-phenyl-quinoline-4-carboxylic acid methyl ester 
• 473248-87-2 3-(1,4'-bipiperidin-1'-ylmethyl)-2-phenyl-4-quinolinecarboxylic acid 

Relevant articles and documents

Discovery of GSK2193874: An Orally Active, Potent, and Selective Blocker of Transient Receptor Potential Vanilloid 4

Transient Receptor Potential Vanilloid 4 (TRPV4) is a member of the Transient Receptor Potential (TRP) superfamily of cation channels. TRPV4 is expressed in the vascular endothelium in the lung and regulates the integrity of the alveolar septal barrier. Increased pulmonary vascular pressure evokes TRPV4-dependent pulmonary edema, and therefore, inhibition of TRPV4 represents a novel approach for the treatment of pulmonary edema associated with conditions such as congestive heart failure. Herein we report the discovery of an orally active, potent, and selective TRPV4 blocker, 3-(1,4′-bipiperidin-1′-ylmethyl)-7-bromo-N-(1-phenylcyclopropyl)-2-[3-(trifluoromethyl)phenyl]-4-quinolinecarboxamide (GSK2193874, 28) after addressing an unexpected off-target cardiovascular liability observed from in vivo studies. GSK2193874 is a selective tool for elucidating TRPV4 biology both in vitro and in vivo.

QUINOLINE 4-CARBOXAMIDE DERIVATIVES AND THEIR USE AS NEUROKININ 3 (NK-3) RECEPTOR ANTAGONISTS

The invention relates to novel quinoline derivatives, processes for their preparation, pharmaceutical compositions containing them and their use as medicaments particularly in treating disorders of the central nervous system (CNS).

Quinoline derivatives as NK-2 and NK-3 receptor ligands

A compound, or a solvate or a salt thereof, of formula (I): wherein R is linear or branched alkyl; R1represents hydrogen or up to four optional substituents selected from the list consisting of: C1-6alkyl, C1-6alkenyl, ary