75029-44-6Relevant articles and documents
PYRIMIDOPYRIMIDINES, PYRIMIDOPYRIMIDOAZEPINES, AND AN IMIDAZOTRIAZINE BY THREE COMPONENT REACTION
Wamhoff, Heinrich,Schmidt, Andreas
, p. 1055 - 1066 (1993)
Recent examples of the three component reaction: iminophosphoranes / isocyanates / heteroarenes (imines) are described.The uracil (1) affords with O-methyl-ε-caprolactim ether and isocyanates the pyrimidopyrimidoazepines (6a-c) and with benzylideneaniline (8) the pyrimidopyrimidines (9a-d), while azodicarboxylate gives the isofervenuline, pyrimidotriazine (11).Furthermore, pyrimidopyrimidine (15) is obtained via 14 from 1, N-phenylbenzimidoyl chloride (13), and phenylisocyanate, while the tautomeric mixture 17A 17B results from treatment of 6-aminouracil (16) with 13; interception with dimethyl acetylenedicarboxylate gives the pyridopyrimidine (19).