2491-91-0

Basic information

• Product Name: 2,5-di-(4-methylphenyl)-1,3-4-oxadiazole
• Synonyms: 2,5-di-(4-methylphenyl)-1,3-4-oxadiazole;2,5-di(p-tolyl)-1,3,4-oxadiazole
• CAS NO: 2491-91-0
• Molecular Formula: C₁₆H₁₄N₂O
• Molecular Weight: 250.30
• Mol File: 2491-91-0.mol
• Article Data: 38

Chemical Properties

• Boiling Point: 399 °C at 760 mmHg
• Flash Point: 189.3 °C
• Appearance: /
• Density: 1.128 g/cm³
• Vapor Pressure: 3.26E-06mmHg at 25°C
• Refractive Index: 1.577
• CAS DataBase Reference: 2,5-di-(4-methylphenyl)-1,3-4-oxadiazole(CAS DataBase Reference)
• NIST Chemistry Reference: 2,5-di-(4-methylphenyl)-1,3-4-oxadiazole(2491-91-0)
• EPA Substance Registry System: 2,5-di-(4-methylphenyl)-1,3-4-oxadiazole(2491-91-0)

Safety Data

• Hazardous Substances Data: 2491-91-0(Hazardous Substances Data)

Usage

General Description

2,5-di-(4-methylphenyl)-1,3,4-oxadiazole is a chemical compound with the molecular formula C16H14N2O. It is a member of the 1,3,4-oxadiazole class of compounds, which are known for their diverse range of biological and pharmacological activities. This particular compound is a crystalline solid that is commonly used in the field of organic synthesis as a building block for the preparation of various functional materials, such as liquid crystals, polymers, and organic semiconductors. Its unique structure and properties make it a valuable tool in the development of advanced materials for use in various industrial and scientific applications.

InChI:InChI=1/C16H14N2O/c1-11-3-7-13(8-4-11)15-17-18-16(19-15)14-9-5-12(2)6-10-14/h3-10H,1-2H3

Upstream product

• 874-60-2 4-methyl-benzoyl chloride 
• 3619-22-5 p-toluic hydrazide 
• 100-47-0 benzonitrile 
• 139030-29-8 (1E,2E)-1,2-bis(4-methylbenzylidene)hydrazine 
• 827-58-7 2-p-tolyl-1,3,4-oxadiazole 
• 36719-51-4 3,3-diethyl-1-(4-methylphenyl)-1-triazene 
• 106-38-7 para-bromotoluene 
• 104-85-8 para-methylbenzonitrile 
• 67-66-3 chloroform 
• 624-31-7 4-tolyl iodide 
• 24994-04-5 5-(4-methylphenyl)-2H-tetrazole 
• 51973-26-3 3,6-di-p-tolyl-[1,2,4,5]tetrazine 
• 824-79-3 sodium 4-methylbenzenesulfinate 
• 104-87-0 4-methyl-benzaldehyde 

Downstream Products

• 41259-89-6 4,4'-(1,3,4-oxadiazole-2,5-diyl)dibenzoic acid 
• 16112-40-6 4-phenyl-3,5-di-p-tolyl-4H-[1,2,4]triazole 
• 16112-12-2 3,4,5-tri-p-tolyl-4H-[1,2,4]triazole 
• 500615-68-9 C₃₀H₂₈N₄O₅S₂ 
• 67603-32-1 C₁₆H₁₆N₄O 
• 58370-38-0 diethyl 4-(5-(4-(diethoxyphosphino)methylphenyl)-1,3,4-oxadiazol-2-yl)-benzyl-phosphonate 
• 500615-67-8 2,5-bis-(4-methyl-3-nitro-phenyl)-[1,3,4]oxadiazole 
• 58370-39-1 2,5-bis[4-(bromomethyl)phenyl]-1,3,4-oxadia-zole 
• 787-84-8 N'-benzoylbenzohydrazide 
• 75029-44-6 1,3-dimethyl-5-benzoylpyrimidine-2,4(1H,3H)-dione 
• 75029-41-3 1,3-Dimethyl-5-(4-methylbenzoyl)uracil-(4-methylbenzoyl)hydrazon 
• 65-85-0 benzoic acid 
• 61528-64-1 2,5-di-p-tolyl-(5ar,10ac)-10,10a-dihydro-5aH-indeno[1,2-f][1,3,4]oxadiazepine 

Relevant articles and documents

New heterocycle-based organic molecule with two-photon induced blue fluorescent emission

A new heterocycle-based quadrupolar molecule containing 2,5-diphenyl-1,3,4-oxadiazole as the n -centre and two carbazoles as end units has been synthesized. It exhibits two-photon induced blue emission, and its two-photon absorption cross section in the femtosecond region is measured to be 239 × 10-50 cm4 s photon-1 at a wavelength of 788 nm. CSIRO 2006.

Multipolar symmetric and asymmetric N–heterocyclic compounds with efficient two?photon absorption

A series of novel multipolar symmetric and asymmetric N–heterocyclic compounds with different configurations were designed and synthesized. Their structures were characterized by Fourier transform infrared spectroscopy, hydrogen?1 nuclear magnetic resonan

Mixed N-heterocycles/N-heterocyclic carbene palladium(II) allyl complexes as precatalysts for direct arylation of azoles with aryl bromides

A series of mixed N-heterocycles/N-heterocyclic carbene palladium(II) allyl complexes with general formula [(NHC)Pd(η3-allyl)]2(μ2-N-heterocycles)(BF4)2 were prepared in one pot based on anion metathesis of (NHC)Pd(η3-allyl)Cl complexes and then ligand replacement with N-heterocycles [N-heterocycles = pyrazine (pyz), 4,4′-bipyridine (bpy) and trans-4,4′-bipyridylethylene (bpe)]. The solid-state structures shown dinuclear structures with two palladium(II) centers holding together by bridged N-heterocycles. Initially investigation of the obtained complexes as precatalysts for direct C[sbnd]H bond arylation of azoles with aryl bromides was carried out.

Synthesis method of 2,5-disubstituted-1,3,4-oxadiazole

The invention discloses a synthesis method of a drug intermediate, namely, 2,5-disubstituted-1,3,4-oxadiazole. 2,5-disubstituted-1,3,4-oxadiazole is synthesized with a one-pot method under the photocatalytic action with simple hydrazide compounds as raw materials. 2,5-disubstituted-1,3,4-oxadiazole can be produced through a reaction at the room temperature with a common halogen lamp as a light source, eosinY as a catalyst, potassium carbonate as an additive and ethanol as a solvent. The method has the characteristics that the raw material source is simple, the reaction condition is mild and the like.