- New heterocycle-based organic molecule with two-photon induced blue fluorescent emission
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A new heterocycle-based quadrupolar molecule containing 2,5-diphenyl-1,3,4-oxadiazole as the n -centre and two carbazoles as end units has been synthesized. It exhibits two-photon induced blue emission, and its two-photon absorption cross section in the femtosecond region is measured to be 239 × 10-50 cm4 s photon-1 at a wavelength of 788 nm. CSIRO 2006.
- Shao, Pin,Li, Zhen,Qin, Jingui,Gong, Hongmei,Ding, Sha,Wang, Ququan
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Read Online
- A selective colorimetric and fluorescent sensor for Al3+ ion and its application to cellular imaging
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A new rhodamine-based fluorescent turn-on chemosensor (L) for selective detection of Al3+ ion has been developed and characterized. The fluorescent chemosensor L was synthesized by the reaction of intermediate (4) with 2,5-bis (4-phenylacyl chl
- Manjunath, Rangasamy,Hrishikesan, Elango,Kannan, Palaninathan
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Read Online
- Multipolar symmetric and asymmetric N–heterocyclic compounds with efficient two?photon absorption
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A series of novel multipolar symmetric and asymmetric N–heterocyclic compounds with different configurations were designed and synthesized. Their structures were characterized by Fourier transform infrared spectroscopy, hydrogen?1 nuclear magnetic resonan
- Cai, Zhi-Bin,Bai, Li,Pan, Yu-Lu,Ma, Fei-Fei,Li, Sheng-Li,Tian, Yu-Peng
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Read Online
- One pot solvent-free solid state synthesis, photophysical properties and crystal structure of substituted azole derivatives
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A solvent-free solid state method has been developed to synthesize three series of substituted azole derivatives (including 1,3,4-oxadiazole, 1,3,4-thiadiazole and 1,2,4-triazole) in high yields by condensation cyclization of N,N′-bishydrazide derivatives with corresponding cyclization agents, respectively. This general method avoids the use of organic solvents, saves cost and resources, simplifies post-processing and increases reaction rates. These compounds have been fully characterized by 1H NMR, 13C NMR, elemental analysis and MS. The structure of 2,5-di (4-tertbutylphenyl)-1,3,4-oxadiazole has been determined by single crystal X-ray diffraction analysis. The cell parameters are as follows: monoclinic crystal system, Cc space group, a = 18.735 (2) ?, b = 6.3375 (8) ?, c = 16.824 (2) ? and α = γ = 90°; β = 98.292 (2). The electronic absorption and fluorescent properties of these compounds have been systematically investigated for the first time. The relationships between heterocyclic structures and photophysical properties have been discussed. The alteration of emission and absorption wavelengths can be elucidated by hybrid atoms' electronegativity and Substituents' Hammett constants. This approach proposes a novel insight to provide a great number of novel substituted azole derivatives with good photophysical properties by a general green method.
- Du, Yanting,Wan, Zilu,Chen, Lianqing,Wu, Lamei
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p. 315 - 325
(2019/05/27)
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- Palladium-catalyzed direct C2-arylation of azoles with aromatic triazenes
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A highly efficient palladium-catalyzed arylation of azoles at the C2-position using 1-aryltriazenes as aryl reagents was developed. Azoles including oxazoles, thiazoles, imidazoles, 1,3,4-oxadiazoles, and oxazolines could react with 1-aryltriazenes smoothly to generate the corresponding products in good to excellent yields, and various substitution patterns were tolerated toward the reaction.
- Liu, Can,Wang, Zhiming,Wang, Lei,Li, Pinhua,Zhang, Yicheng
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p. 9209 - 9216
(2019/11/05)
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- Mixed N-heterocycles/N-heterocyclic carbene palladium(II) allyl complexes as precatalysts for direct arylation of azoles with aryl bromides
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A series of mixed N-heterocycles/N-heterocyclic carbene palladium(II) allyl complexes with general formula [(NHC)Pd(η3-allyl)]2(μ2-N-heterocycles)(BF4)2 were prepared in one pot based on anion metathesis of (NHC)Pd(η3-allyl)Cl complexes and then ligand replacement with N-heterocycles [N-heterocycles = pyrazine (pyz), 4,4′-bipyridine (bpy) and trans-4,4′-bipyridylethylene (bpe)]. The solid-state structures shown dinuclear structures with two palladium(II) centers holding together by bridged N-heterocycles. Initially investigation of the obtained complexes as precatalysts for direct C[sbnd]H bond arylation of azoles with aryl bromides was carried out.
- Yang, Jin
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p. 2182 - 2187
(2019/02/24)
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- Synthesis method of 2,5-disubstituted-1,3,4-oxadiazole
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The invention discloses a synthesis method of a drug intermediate, namely, 2,5-disubstituted-1,3,4-oxadiazole. 2,5-disubstituted-1,3,4-oxadiazole is synthesized with a one-pot method under the photocatalytic action with simple hydrazide compounds as raw materials. 2,5-disubstituted-1,3,4-oxadiazole can be produced through a reaction at the room temperature with a common halogen lamp as a light source, eosinY as a catalyst, potassium carbonate as an additive and ethanol as a solvent. The method has the characteristics that the raw material source is simple, the reaction condition is mild and the like.
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Paragraph 0007; 0027
(2018/08/04)
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- Three-component synthesis method of oxadiazole compound
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The invention relates to a synthesis method of an oxadiazole compound shown in formula (III). The method comprises steps as follows: a compound shown in formula (1), a compound shown in formula (II) and an amine source compound react at 80-100 DEG C for 6-10 h in the presence of an organic solvent, a catalyst, base and an additive, after-treatment is performed after the reaction ends, and the compound shown in formula (III) is obtained, wherein R1 is C1-C6 alkyl groups, phenyl groups or phenyl groups substituted with substitute groups, substitute groups are C1-C6 alkyl groups, C1-C6 alkoxy groups or halogen, and R2 is H, C1-C6 alkyl groups, C1-C6 alkoxy groups or halogen. A specific three-component reaction system is adopted in the method, comprehensive synergism of a specific catalytic system is combined, so that a target product can be obtained at the high yield, and the method has good application prospect and value.
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Paragraph 0040-0043
(2017/05/12)
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- Reagent/Substituent Switching Approach for the Synthesis of Substituted 1,3,4-Oxadiazole/1,3,4-Oxadiazoline and 1,2,4-Triazole Derivatives from N-Substituted Hydrazides
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A metal-free method for the synthesis of substituted 1,3,4-oxadiazole/1,3,4-oxadiazoline and 1,2,4-triazole derivatives from a common starting material via reagent/substituent switching is reported. In the presence of 2-fluoropyridine/triflic anhydride, 1,3,4-oxadiazole derivatives were exclusively formed from N′-tert-butylhydrazides and 1,3,4-oxadiazoline derivatives were produced from N-phenylhydrazides. On the other hand, when using pyridine/triflic anhydride, salts of 1,2,4-triazoles were the sole products. (Figure presented.).
- Kotipalli, Trimurtulu,Kavala, Veerababurao,Konala, Ashok,Janreddy, Donala,Kuo, Chu-Wei,Yao, Ching-Fa
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p. 2652 - 2660
(2016/09/03)
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- One-Pot Synthesis of 2,5-Diaryl 1,3,4-Oxadiazoles via Di-tert-butyl Peroxide Promoted N-Acylation of Aryl Tetrazoles with Aldehydes
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A metal- and base-free protocol for one-pot synthesis of 2,5-diaryl 1,3,4-oxadiazoles via a radical-promoted cross-dehydrogenative coupling strategy was developed. This reaction involved the N-acylation of aryl tetrazoles with aryl aldehydes, followed by thermal rearrangement. A wide range of aryl tetrazoles and aryl aldehydes survived the reaction conditions to deliver the corresponding products in moderate to good yields. (Chemical Equation Presented).
- Wang, Liang,Cao, Jing,Chen, Qun,He, Mingyang
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supporting information
p. 4743 - 4748
(2015/05/13)
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- Palladium-Catalyzed Aminocarbonylation Reaction to Access 1,3,4-Oxadiazoles using Chloroform as the Carbon Monoxide Source
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A palladium-catalyzed aminocarbonylation reaction of aryl halides with chloroform and tetrazoles has been developed, where chloroform was employed as the carbon monoxide (CO) source in the presence of cesium hydroxide. The in situ generated N-acylated tetrazoles were unstable and easily decomposed to afford 2,5-disubstituted 1,3,4-oxadiazoles. A wide range of tetrazoles and aryl halides reacted smoothly under the optimized reaction conditions to give the corresponding products in moderate to good yields.
- Li, Zhengyi,Wang, Liang
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p. 3469 - 3473
(2016/01/25)
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- Electrochemical oxidation of aldehyde-N-arylhydrazones into symmetrical-2,5-disubstituted-1,3,4-oxadiazoles
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A convenient, efficient and one-pot synthesis of chemically and pharmaceutically interesting symmetrical-2,5-disubstituted-1,3,4-oxadiazoles is reported. The protocol involves anodic oxidation of aldehyde-N-arylhydrazones in anhyd. MeCN-LiClO4. Constant potential electrolysis carried out in an undivided cell and platinum electrodes leads to the formation of the corresponding oxadiazoles under ambient condition and the mechanism was deduced from voltammetry studies. The reaction proceeded smoothly with high atom economy. Springer Science+Business Media Dordrecht 2013.
- Singh, Sushma,Sharma, Laxmi K.,Saraswat, Apoorv,Siddiqui, Ibadur R.,Singh, Rana K. Pal
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p. 947 - 960
(2014/05/06)
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- Study of heterogeneous catalysis by iron-squarate based 3d metal organic framework for the transformation of tetrazines to oxadiazole derivatives
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We present here a simple, milder, and environmentally benign heterogeneous catalytic method for the transformation of tetrazines to oxadiazole derivatives at room temperature (25 °C) using our earlier synthesized iron-squarate based 3D metal organic framework, [Fe3(OH)3(C 4O4)(C4O4)0.5] n (FeSq-MOF).
- Goswami, Soumyabrata,Jena, Himanshu Sekhar,Konar, Sanjit
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supporting information
p. 7071 - 7073
(2014/08/05)
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- Efficient oxidative cyclization of N -acylhydrazones for the synthesis of 2,5-disubstituted 1,3,4-oxadiazoles using t-BuOI under neutral conditions
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An efficient procedure for the oxidative cyclization of N -acylhydrazones was developed utilizing tert-butyl hypoiodite (t-BuOI), which is generated in situ from t -BuOCl and NaI. A variety of 2,5-disubstituted 1,3,4-oxadiazoles were synthesized in high yields within short reaction time. The method is also suitable for cyclization of N -acylhydrazones derived from heterocyclic aldehydes and aliphatic aldehydes. Mild reaction conditions and simple workup operations make the procedure a good alternative for the synthesis of 2,5-disubstituted 1,3,4-oxadiazoles.
- Gao, Peng,Wei, Yunyang
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p. 113 - 119
(2013/05/23)
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- Electrosynthesis and screening of novel 1,3,4-oxadiazoles as potent and selective antifungal agents
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The electrochemical oxidation of aldehyde-N-aroylhydrazone has been studied in the presence of NaClO4 as supporting electrolyte in MeOH solution using cyclic voltammetry and controlled potential electrolysis. The results indicate that intramolecular cyclization of aldehyde-N-aroylhydrazone has been successfully performed at a platinum electrode in an undivided cell with good yields of the corresponding 1,3,4-oxadiazoles at ambient conditions. The reaction products were characterized by spectroscopic methods and a mechanism was deduced from voltammetry studies. The antifungal activity of the synthesized compounds was evaluated on Fusarium oxysporum, Alternaria solani, Candida albicans and Aspergillus niger. The results revealed that all the synthesized compounds have significant antifungal activity against the tested fungi. Among the synthesized derivatives 7b, 7d, 7g, 7h, 7i, 7j and 7r were found to be the most effective antifungal compounds. The Royal Society of Chemistry 2013.
- Singh, Sushma,Sharma, Laxmi Kant,Saraswat, Apoorv,Siddiqui, Ibadur R.,Kehri, Harbans K.,Singh, Rana K. Pal
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p. 4237 - 4245
(2013/05/08)
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- I2-mediated oxidative C-O bond formation for the synthesis of 1,3,4-oxadiazoles from aldehydes and hydrazides
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A practical and transition-metal-free oxidative cyclization of acylhydrazones into 1,3,4-oxadiazoles has been developed by employing stoichiometric molecular iodine in the presence of potassium carbonate. The conditions of this cyclization reaction also work well with crude acylhydrazone substrates obtained from the condensation of aldehydes and hydrazides. A series of symmetrical and asymmetrical 2,5-disubstituted (aryl, alkyl, and/or vinyl) 1,3,4-oxadiazoles can be conveniently generated in an efficient and scalable fashion.
- Yu, Wenquan,Huang, Gang,Zhang, Yueteng,Liu, Hongxu,Dong, Lihong,Yu, Xuejun,Li, Yujiang,Chang, Junbiao
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p. 10337 - 10343
(2013/11/06)
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- Efficient oxidative cyclisation of acid hydrazides to 2,5-disubstituted 1,3,4-oxadiazoles catalysed by Bu4NI with t-BuOOH as oxidant
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Acid hydrazides or araldehyde N-acylhydrazones can be converted in good yields to, respectively, symmetrical or unsymmetrical, 2,5-disubstituted 1,3,4-oxadiazoles at 60 °C by a Bu4NI-catalysed procedure which requires the presence of a base and 2.5 equiv. of t-butyl hydroperoxide.
- Gao, Peng,Wei, Yunyang
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p. 506 - 510
(2013/09/12)
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- A highly efficient palladium-catalyzed desulfitative arylation of azoles with sodium arylsulfinates
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A highly efficient palladium-catalyzed direct desulfitative arylation of azoles at C2-position has been developed using sodium arylsulfinates as aryl sources. Azoles including benzoxazoles, benzothiazoles, oxazoles, thiazoles, and 1,3,4-oxadiazoles reacted with sodium arylsulfinates smoothly to generate the corresponding products in good to excellent yields, and various substitution patterns were tolerated toward the reaction.
- Wang, Min,Li, Dengke,Zhou, Wei,Wang, Lei
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experimental part
p. 1926 - 1930
(2012/03/26)
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- A new efficient one-pot synthesis of 2,5-diaryl-1,3,4-oxadiazoles
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Symmetrically substituted 2,5-diaryl-1,3,4-oxadiazoles have been prepared in 81-92% yields by a new direct one-pot synthesis from arenecarboxylic acids, hydrazine dihydrochloride, anhydrous phosphoric acid and sodium borohydride in the absence of a solvent at 170-180°C for 5-6h.
- Chiriac, Constantin I.,Tanasa, Fulga,Nechifor, Marioara
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experimental part
p. 1113 - 1117
(2012/08/13)
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- N-chlorosuccinimide/1,8-diazabicyclo[5.4.0]undec-7-ene (DBU)-mediated synthesis of 2,5-disubstituted 1,3,4-oxadiazoles
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A mixture of N-chlorosuccinimide and 1,8-diazabicyclo[5.4.0]undec-7-ene oxidatively cyclizes structurally diverse acyl hydrazone, thereby providing an efficient and convenient method for the synthesis of various 2,5-disubstituted 1,3,4-oxadiazoles. The salient features of this method are mild reaction conditions, short reaction time, excellent yields, and simple workup procedure. Copyright
- Pardeshi, Santosh P.,Patil, Sachin S.,Bobade, Vivek D.
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experimental part
p. 1601 - 1606
(2010/06/20)
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- Synthesis and optical properties of two novel stilbene derivatives containing 1,3,4-oxadiazole moiety
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Two novel stilbene derivatives containing 1,3,4-oxadiazole moiety were synthesized and characterized by elemental analyses, 1H NMR, MS. The photophysical processes of the title compounds were investigated by UV-vis absorption and fluorescence e
- Zhu, Yong-Chuang,He, Dao-Hang,Yang, Zhuo-Ru
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experimental part
p. 417 - 420
(2009/04/13)
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- Synthesis and characterization of novel stilbene derivatives with 1,3,4-oxadiazole unit
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Four novel stilbene derivatives containing 1,3,4-oxadiazole unit have been synthesized in four steps with overall yields (2735%). The synthetic route involved one-step installation of 2,5-di-p-tolyl-1,3,4-oxadiazol via the direct coupling of p-toluic acid
- He, Dao-Hang,Zhu, Yong-Chuang,Yang, Zhuo-Ru,Hu, Ai-Xi
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experimental part
p. 268 - 270
(2009/12/04)
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- Trichloroisocyanuric acid-mediated one-pot synthesis of unsymmetrical 2,5-disubstituted 1,3,4-oxadiazoles at ambient temperature
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An efficient method for the one-pot synthesis of unsymmetrical 2,5-disubstituted 1,3,4-oxadiazoles has been developed using trichloroisocyanuric acid (TCCA) at ambient temperature. A wide variety of aromatic as well as heterocyclic aldehydes exhibit condensation with a variety of acylhydrazines followed by oxidative cyclization to yield corresponding unsymmetrical 2,5-disubstituted 1,3,4-oxadiazoles. The mild nature of the synthesis and short reaction time are notable advantages of the developed protocol. Copyright Taylor & Francis Group, LLC.
- Pore,Mahadik,Desai
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p. 3121 - 3128
(2008/12/22)
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- Oxadiazole metallic complexes and their electronic and opto-electronic applications
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The present invention relates to oxadiazole metallic complexes. More specifically it relates to the synthesis and electronic and opto-electronic applications of oxadiazole metallic complexes having a general Formula I, wherein each of variables is defined herein.
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Page/Page column 5
(2008/06/13)
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- Oxidative cyclization of aldazines with bis(trifluoroacetoxy)iodobenzene
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Symmetrical and unsymmetrical aldazines are efficiently converted to 2,5-disubstituted-1,3,4-oxadiazoles by oxidation with bis(trifluoroacetoxy) iodobenzene (BTI).
- Shang, Zhenhua,Reiner, John,Chang, Junbiao,Zhao, Kang
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p. 2701 - 2704
(2007/10/03)
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- Synthesis and optically acid-sensory and electrochemical properties of novel polyoxadiazole derivatives
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A series of PPV-based polyoxadiazoles have been synthesized by Horner and Suzuki coupling polymerization to investigate their structure-property relationship. These copolymers exhibit good thermal stability (decomposition temperature around 352-413°C). Ex
- Wu, Tzi-Yi,Sheu, Rong-Bin,Chen, Yun
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p. 725 - 733
(2007/10/03)
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- Polymer light-emitting diodes based on a bipolar transporting luminescent polymer
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A soluble electroluminescent polymer containing hole-deficient triphenylamine and electron-deficient oxadiazole units in the main chains has been designed and studied. The design is based on the consideration that the triphenylamine group possesses good hole-transporting property and the oxadiazole unit is known to be of electron-transporting character. Because of the good bipolar transporting performance, the brightness and electroluminescent efficiency are significantly improved and the turn-on voltage is reduced compared with a similar polymer without the electron-deficient oxadiazole units in the main chains. For a device with configuration ITO/PEDOT/polymer/CsF/Al, a maximum brightness of 3600 cd m-2 and a maximum luminescent efficiency of 0.65 cd A-1 (quantum efficiency of 0.3%) were obtained in the polymer with oxadiazole units, about 15 times brighter and 15 times more efficient than the corresponding polymer without oxadiazole units.
- Zhang, Yanguang,Hu, Yufeng,Li, Hongchao,Wang, Lixiang,Jing, Xiabin,Wang, Fosong,Ma, Dongge
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p. 773 - 777
(2007/10/03)
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- Facile synthesis of symmetric and unsymmetric 1,3,4-oxadiazoles using 2-acyl(or aroyl)pyridazin-3-ones
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Symmetric and unsymmetric 1,3,4-oxadiazoles were synthesized in situ from hydrazine hydrate and the corresponding 2-acyl-4,5-dichloropyridazin-3-ones as acylating agents in polyphosphoric acid or BF3·OEt2 in excellent yields.
- Park, Yong-Dae,Kim, Jeum-Jong,Chung, Hyun-A,Kweon, Deok-Heon,Cho, Su-Dong,Lee, Sang-Gyeong,Yoon, Yong-Jin
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p. 560 - 564
(2007/10/03)
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- Synthesis and characterization of a novel charge transfer compound with large three-photon absorption cross section
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A new intramolecular charge transfer compound containing diethylamino group as electronic donor and oxadiazole group as electronic acceptor has been synthesized using Wittig-Horner reaction. This long conjugated molecule has large three-photon absorption cross section excited at 1.06 μm lasing.
- Zhang, Junxiang,Cui, Yiping,Wang, Mingliang,Xu, Chunxiang,Zhong, Yuan,Liu, Juzheng
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p. 824 - 825
(2007/10/03)
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- Rapid synthesis of 2,5-disubstituted 1,3,4-oxadiazoles under microwave irradiation
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A number of symmetrically 2,5-disubstituted 1,3,4-oxadiazoles are quickly prepared by the reaction of aromatic acids with hydrazine dihydrochloride in a mixture of orthophosphoric acid and phosphorus pentoxide under microwave irradiation.
- Bentiss, Fouad,Lagrenee, Michel,Barbry, Didier
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p. 935 - 938
(2007/10/03)
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- 2-Chloro-1,3-dimethylimidazolinium chloride. 2. Its application to the construction of heterocycles through dehydration reactions
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2-Chloro-1,3-dimethylimidazolinium chloride (DMC) (1) can act as a powerful dehydrating equivalent to DCC (2) under nearly neutral conditions. Its application to the construction of heterocycles through dehydration reactions is described.
- Isobe, Toshio,Ishikawa, Tsutomu
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p. 6989 - 6992
(2007/10/03)
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- A new synthesis of symmetrical 2,5-disubstituted 1,3,4- oxadiazoles
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Several new 2,5-disubstituted 1,3,4-oxadiazoles have been synthesized in good yields by reaction of aromatic acids with hydrazine dihydrochloride in a mixture of orthophosphoric acid, phosphorus pentoxide and, in general, with addition of phosphorus oxychloride to the reaction mixture. The structures of new oxadiazoles derivatives were confirmed by analytical and spectral data.
- Bentiss, Fouad,Lagrenee, Michel
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p. 1029 - 1032
(2007/10/03)
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- A new synthesis of 1,3,4-oxadiazoles. Cyclization of N,N'- diacylhydrazines catalyzed by palladium(0)
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Several 1,3,4-oxadiazoles were synthetized by cyclization of N,N'- diacylhydrazines catalyzed by palladium(0). Water formed during the reaction is responsible for the hydrolysis of the products. To avoid it, we introduced benzoic anhydride into the medium and obtained an increased yield of oxadiazoles.
- Lutun, Stephane,Hasiak, Bruno,Couturier, Daniel
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p. 111 - 116
(2007/10/03)
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- Polyphosphoric acid and anhydrous aluminium chloride catalysed novel rearrangements of 1,5-diaroylcarbohydrazides
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1,5-Diaroylcarbohydrazides 1 on reaction with polyphosphoric acid (PPA) at 150 deg C for 15 min undergo an interesting rearrangement to afford 2,5-diaryl-1,3,4-oxadiazoles 2. However, the reaction of 1 with anhydrous aluminium chloride yields 1,2-diaroylhydrazines 3.
- Karnik, A. V.,Kamath, Rajesh G.
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p. 803 - 804
(2007/10/03)
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- Fusion of Aroylhydrazines with Acids - A New Synthesis of 2,5-Diaryl-1,3,4-oxadiazoles
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Aroylhydrazines and aromatic acids when heated together at 240 deg C for 6 hr yield 2,5-diaryl-1,3,4-oxadiazoles (V) in one step.Permanganate oxidation of 1-aroyl-2-arylidenehydrazines is also shown to be a superior method for preparing 1,3,4-oxadiazoles (V).
- Reddy, P. S. N.,Reddy, P. Pratap
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p. 890 - 891
(2007/10/02)
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- The Synthesis Of (1,3,4-Oxadiazole-2,5-Diyl) Dibenzoic Acids and Their Thiadiazole Analogues
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The title compounds are best prepared by oxidation of the corresponding 2,5-ditolyl-1,3-4-oxadiazole or -thiadiazole, and are most easily characterised by the 13C n.m.r. spectra of their di-potassium salts.
- Javaid, Khalid,Smith, David M.
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p. 985 - 997
(2007/10/02)
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- Synthetic Approaches to Phthalazines: C-N Bond Cleavage in 2'-Benzylbenzohydrazides During Reaction with Polyphosphoric Acid
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Reaction of 2'-benzylbenzohydrazides with concentrated polyphosphoric acid gave 2,5-diaryl-1,3,4-oxadiazoles and a polybenzyl.Cyclodehydration to phthalazines was not observed.It is inferred from product substitution patterns that CH2-N bond cleavage occurs with polybenzyls forming from the benzyl moiety and oxadiazoles from the benzohydrazide fragment.Other reported reactions which generate benzyl fragments lead to bibenzyl and are considered to involve trapping of the cleavage products within a solvent cage.The observed production of polybenzyls is therefore interpreted in terms of the formation of free benzyl fragments.A tetrahydrophthalazine derivative was produced from the addition of diethyl azodicarboxylate to the photodiene of o-methylbenzophenone, but this could not be converted into a phthalazine.
- Paul, D. Brenton
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p. 893 - 901
(2007/10/02)
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- Reaction of Substituted Acid Hydrazides with Substituted Benzonitriles: Formation of Isomeric Triazoles
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The reaction of substituted benzoic acid hydrazides with substituted benzonitriles yields besides 3,5-di(substituted phenyl)-4H-1,2,4 (5-8)- and -1H-1,2,4 (1-4)-triazoles, the 2,5-di(substituted phenyl)-1,3,4-oxadiazoles (9-12).
- Neelima,Bhaduri, A. P.
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