7516-60-1

Basic information

• Product Name: 4-(chlorosulphonyl)benzoyl chloride
• Synonyms: 4-(chlorosulphonyl)benzoyl chloride;4-(Chlorosulfonyl)benzoic acid chloride;Einecs 231-371-9;4-(Chlorosulfonyl)benzoyl chloride
• CAS NO: 7516-60-1
• Molecular Formula: C7H4Cl2O3S
• Molecular Weight: 239.07586
• EINECS: 231-371-9
• Mol File: 7516-60-1.mol
• Article Data: 23

Chemical Properties

• Boiling Point: 335.1°C at 760 mmHg
• Flash Point: 156.5°C
• Appearance: /
• Density: 1.567g/cm³
• Vapor Pressure: 0.000122mmHg at 25°C
• Refractive Index: 1.569
• CAS DataBase Reference: 4-(chlorosulphonyl)benzoyl chloride(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(chlorosulphonyl)benzoyl chloride(7516-60-1)
• EPA Substance Registry System: 4-(chlorosulphonyl)benzoyl chloride(7516-60-1)

Safety Data

• Hazardous Substances Data: 7516-60-1(Hazardous Substances Data)

Usage

General Description

4-(chlorosulphonyl)benzoyl chloride, also known as 4-(chlorosulfonyl)benzoyl chloride, is a chemical compound that is widely used in organic synthesis and as a reagent in industrial processes. It is a highly reactive and corrosive compound with the molecular formula C7H4ClO3S and a molar mass of 222.62 g/mol. This chemical is a derivative of benzoic acid and is used in the production of pharmaceuticals, agrochemicals, and dyes. It is a versatile building block for the synthesis of various compounds and is known for its ability to introduce the chlorosulfonyl group into organic molecules. Due to its reactivity and potential hazards, proper safety measures and handling procedures must be followed when working with 4-(chlorosulphonyl)benzoyl chloride.

InChI:InChI=1/C7H4Cl2O3S/c8-7(10)5-1-3-6(4-2-5)13(9,11)12/h1-4H

Upstream product

• 10130-89-9 p-carboxyphenylsulfonyl chloride 
• 75-44-5 phosgene 
• 636-78-2 4-sulphobenzoic acid 
• 22959-32-6 p-sulfobenzoic acid potassium salt 
• 5399-63-3 potassium p-carboxybenzenesulfonate 
• 104-15-4 toluene-4-sulfonic acid 

Downstream Products

• 69812-51-7 4-chlorosulfonyl-benzoic acid methyl ester 
• 26737-96-2 N-phenyl-4-(N-phenylsulfamoyl)benzamide 
• 152278-01-8 4-[2-(4-Dimethylamino-phenyl)-2-oxo-ethylcarbamoyl]-benzenesulfonyl chloride 
• 120133-60-0 4-(5-Phenyl-oxazol-2-yl)-benzenesulfonyl chloride 
• 120133-62-2 4-[5-(4-Methoxy-phenyl)-oxazol-2-yl]-benzenesulfonyl chloride 
• 120133-61-1 4-(5-Biphenyl-4-yl-oxazol-2-yl)-benzenesulfonyl chloride 
• 71888-22-7 N,N-diethyl-4-<(diethylamino)sulfonyl>benzamide 
• 455-26-5 4-carboxybenzenesulfonyl fluoride 
• 1160839-55-3 isobutyl 4-(isobutoxysulfonyl)benzoate 
• 26933-74-4 4-(phenylcarbamoyl)benzenesulfonyl chloride 

Relevant articles and documents

A structurally guided dissection-then-evolution strategy for ligand optimization of smoothened receptor

We present herein a novel dissection-then-evolution strategy for ligand optimization. Using the co-crystal structure of the smoothened receptor (SMO) as a guide, we studied the modular contribution of LY2940680 by systematically silencing the specific interaction between the individual residue(s) and the fragment in the ligand. Following evolution by focusing on the benzoyl part finally yielded an improved ligand 21.

FLUORINATED SULFONATE ESTERS OF ARYL KETONES FOR NON-IONIC PHOTO-ACID GENERATORS

Non-ionic photo-acid generating (PAG) compounds were prepared that contain an aryl ketone group having a perfluorinated substituent alpha to the ketone carbonyl. The non-polymeric PAGs release a sulfonic acid when exposed to high energy radiation such as deep UV or extreme UV light. The photo-generated sulfonic acid has a low diffusion rate in an exposed resist layer subjected to a post-exposure bake (PEB) at 100° C. to 150° C., resulting in formation of good line patterns after development. At higher temperatures, the PAGs can also undergo a thermal reaction to form a sulfonic acid. The perfluorinated substituent provides improved thermal stability and hydrolytic/nucleophilic stability.

NON-CHROMATOGRAPHIC PURIFICATION OF MACROCYCLIC PEPTIDES BY A RESIN CATCH AND RELEASE

The disclosure is directed to compounds and methods for preparing purified macrocyclic peptide using "catch-release" methods. These methods comprise reacting a free amino group of a resin-bound linear peptide with an azide- or alkyne-functionalized cap to form a resin-bound capped linear peptide having an azide- or alkyne-functionalized cap; cleaving said capped linear peptide from the resin to form a free capped linear peptide having an azide- or alkyne-functionalized cap; reacting the free capped linear peptide having an azide-functionalized cap with an alkyne-functionalized catch resin, or reacting the free capped linear peptide having an akynyl-functionalized cap with an azide functionalized catch resin, to form a catch-resin bound capped linear peptide; reacting the catch-resin bound capped linear peptide under conditions sufficient to effect macrocyclization of the linear peptide and release of the macrocyclic peptide from the catch resin.