75238-80-1

Basic information

• Product Name: 3,4-dicyano-6-hydroxy-4,6-diphenyl-piperidin-2-one
• Synonyms: 3,4-dicyano-6-hydroxy-4,6-diphenyl-piperidin-2-one
• CAS NO: 75238-80-1
• Molecular Weight: 317.347
• Mol File: 75238-80-1.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 3,4-dicyano-6-hydroxy-4,6-diphenyl-piperidin-2-one(CAS DataBase Reference)
• NIST Chemistry Reference: 3,4-dicyano-6-hydroxy-4,6-diphenyl-piperidin-2-one(75238-80-1)
• EPA Substance Registry System: 3,4-dicyano-6-hydroxy-4,6-diphenyl-piperidin-2-one(75238-80-1)

Safety Data

• Hazardous Substances Data: 75238-80-1(Hazardous Substances Data)

Upstream product

• 20413-05-2 (E)-2-Benzoyl-3-phenyl-acrylonitrile 
• 107-91-5 cyanoacetic acid amide 
• 20413-05-2 2-benzoyl-3-phenylacrylonitrile 

Downstream Products

• 100784-48-3 3-carbamoyl-5-cyano-4,6-diphenylpyridine-2(1H)-one 
• 100784-53-0 6-oxo-2,4-diphenyl-1,6-dihydropyridine-3-carbonitrile 
• 75238-89-0 3-carbamoyl-5-cyano-4,6-diphenyl-3,4-dihydropyridin-2-(1H)-one 
• 75617-37-7 3,5-dicyano-4,6-diphenyl-3,4-dihydropyridin-2(1H)-one 
• 75238-99-2 1,2-dihydro-2-oxo-4,6-diphenyl-3,5-pyridinedicarbonitrile 

Relevant articles and documents

Synhesis of Heterocyclic Compounds. Part 46. The reactions of Malonamide and 2-Cyanoacetamide with Substituted Propenones

The synthesis of substituted 2-pyridone derivatives from malonamide (1) and 2-cyanoacetamide (2) is reported.Conjugate addition of these compounds to substituted propenones (3) and (4) leads to 6-hydroxy-2-piperidones, which can be dehydrated and aromatiz

SYNTHESIS OF HETEROCYCLIC COMPOUNDS XIX PREPARATION OF 4,6-DIARYL-3,5-DICYANO-2-PYRIDONES

Reaction of cyanoacetamide with α-benzoylcinnamonitriles (I) leads to a new series of 4,6-diaryl-3,5-dicyano-2-pyridones (IV). The initial Michael's addition is followed by a cyclization to a 6-hydroxy-2-piperidone ring (II), whose acid dehydration gives rise to 3,4-dihydro-2-pyridones (III).The latter are easily aromatized to 4,6-diaryl-3,5-dicyano-2-pyridones (IV) by treatment with sodium nitrite in sulfuric acid.