75286-49-6Relevant articles and documents
Delivery and Release of Small-Molecule Probes in Mitochondria Using Traceless Linkers
Lei, Eric K.,Kelley, Shana O.
, p. 9455 - 9458 (2017)
Mitochondria-penetrating peptides (MPPs) are specific targeting vectors for the localization of small molecules to the mitochondrial matrix. Mitochondrial targeting of small molecules has enabled the development of a number of potential therapeutics and c
MITOCHONDRIAL TARGETED RELEASABLE LINKER
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Paragraph 0072, (2019/01/15)
There is described herein compound comprising a mitochondrial targeting portion, a cargo portion including a drug unit, and a linker conjugating the mitochondrial targeting portion and the cargo portion, the linker portion cleavable in a mitochondrion of
DERIVATIVES OF SUCCINIC AND GLUTARIC ACIDS AND ANALOGS THEREOF USEFUL AS INHIBITORS OF PHEX
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Page 41, (2010/02/07)
The present invention relates to derivatives of succinic and glutaric acids and analogues thereof, having the following general formula (I), useful as inhibitors of PHEX. These derivatives are useful for promoting generation of bone mass and treating or preventing diseases or conditions associated with a phosphate metabolism defect. Methods for preparation and intermediates are also disclosed.