75321-85-6

Basic information

• Product Name: 2-(2-FLUOROPHENYL)ACETALDEHYDE
• Synonyms: 2-(2-FLUOROPHENYL)ACETALDEHYDE;2-fluorophenylacetaldehyde
• CAS NO: 75321-85-6
• Molecular Formula: C₈H₇FO
• Molecular Weight: 138.1389832
• Mol File: 75321-85-6.mol
• Article Data: 19

Chemical Properties

• Boiling Point: 199.4 °C at 760 mmHg
• Flash Point: 73.2 °C
• Appearance: /
• Density: 1.116 g/cm³
• Vapor Pressure: 0.343mmHg at 25°C
• Refractive Index: 1.493
• Storage Temp.: Inert atmosphere,Store in freezer, under -20°C
• CAS DataBase Reference: 2-(2-FLUOROPHENYL)ACETALDEHYDE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(2-FLUOROPHENYL)ACETALDEHYDE(75321-85-6)
• EPA Substance Registry System: 2-(2-FLUOROPHENYL)ACETALDEHYDE(75321-85-6)

Safety Data

• Hazardous Substances Data: 75321-85-6(Hazardous Substances Data)

Usage

General Description

2-(2-Fluorophenyl)acetaldehyde is a chemical compound with the molecular formula C8H7FO. It is a colorless liquid with a distinctive aromatic odor, and is used primarily as an intermediate in the production of pharmaceuticals and agrochemicals. It is also used in organic synthesis as a building block for various chemical reactions. 2-(2-Fluorophenyl)acetaldehyde can be hazardous if not handled properly, and protective measures should be taken when working with this compound to avoid skin and eye irritation, as well as inhalation and ingestion hazards.

InChI:InChI=1/C8H7FO/c9-8-4-2-1-3-7(8)5-6-10/h1-4,6H,5H2

Upstream product

• 57486-67-6 methyl o-fluorophenylacetate 
• 74249-17-5 (S)-2-(2-fluorophenyl)oxirane 
• 446-52-6 2-Fluorobenzaldehyde 
• 766-49-4 (2-fluorophenyl)acetylene 
• 394-46-7 2-fluorostyrene 
• 584-74-7 o-fluorophenylacetic acid ethyl ester 
• 451-82-1 (2-fluorophenyl)acetic acid 
• 54533-38-9 1-fluoro-2-(2-methoxyvinyl)benzene 
• 50919-06-7 2-(2-fluorophenyl)ethanol 

Downstream Products

• 1219025-78-1 (E/Z)-4-(2-fluorophenyl)-2-methylbut-2-enol 
• 1219025-80-5 4-(2-fluorophenyl)-2-methylbutanol 
• 1219025-82-7 4-(2-fluorophenyl)-2-methylbromobutane 
• 1219025-84-9 8-(2-fluorophenyl)-2,2,6-trimethyl-4-(1H-1,2,4-triazol-1-yl)-octan-3-one 
• 89346-49-6 3-(2-fluorophenyl)pyridine 
• 52721-69-4 [2-(2-fluorophenyl)ethyl]amine 
• 1338349-48-6 N-[2-ethyl-2-(4-fluorophenyl)butyl]-1-[2-(2-fluorophenyl)ethyl]piperidine-4-carboxamide oxalate 
• 1219025-76-9 (E/Z)-ethyl 4-(2-fluorophenyl)-2-methylbut-2-enoate 
• 126348-27-4 (Z)-1,4-di(2-fluorophenyl)but-2-ene 
• 46322-12-7 C₉H₁₁FN₄ 

Relevant articles and documents

Novel Hypoxia-Inducible Factor 1α (HIF-1α) Inhibitors for Angiogenesis-Related Ocular Diseases: Discovery of a Novel Scaffold via Ring-Truncation Strategy

Ocular diseases featuring pathologic neovascularization are the leading cause of blindness, and anti-VEGF agents have been conventionally used to treat these diseases. Recently, regulating factors upstream of VEGF, such as HIF-1α, have emerged as a desirable therapeutic approach because the use of anti-VEGF agents is currently being reconsidered due to the VEGF action as a trophic factor. Here, we report a novel scaffold discovered through the complete structure-activity relationship of ring-truncated deguelin analogs in HIF-1α inhibition. Interestingly, analog 6i possessing a 2-fluorobenzene moiety instead of a dimethoxybenzene moiety exhibited excellent HIF-1α inhibitory activity, with an IC50 value of 100 nM. In particular, the further ring-truncated analog 34f, which showed enhanced HIF-1α inhibitory activity compared to analog 2 previously reported by us, inhibited in vitro angiogenesis and effectively suppressed hypoxia-mediated retinal neovascularization. Importantly, the heteroatom-substituted benzene ring as a key structural feature of analog 34f was identified as a novel scaffold for HIF-1α inhibitors that can be used in lieu of a chromene ring.

Stereoselective synthesis of 3,4-di-substituted mercaptolactones via photoredox-catalyzed radical addition of thiophenols

A visible light mediated radical addition of thiophenols on 4-phenylbut-3-enoic acids to give diastereoselective synthesis of 3,4-disubstituted γ-lactones is reported. The reaction precludes the conventional prerequisite of conjugate addition. Furthermore, the lactones were successfully utilized in the synthesis of γ-ketoamides.

Synthesis of 3-Arylpyridines via Palladium/Copper-Catalyzed Annulation of Allylamine/1,3-Propanediamine and Aldehydes

A novel and efficient method for the synthesis of 3-arylpyridines from allylamine/propanediamine and aldehydes by palladium/copper-catalyzed oxidative tandem cyclization has been developed. With this reaction, a series of desired 3-arylpyridines was synthesized in moderate yields via C-C/C-N bond formation and 6-endo/exo-trig cyclization.