75507-26-5 Usage
Description
2-(HYDROXYMETHYL)-12-CROWN 4-ETHER is an organic compound belonging to the crown ether family, characterized by its unique structure that allows it to form complexes with specific ions. It is known for its ability to selectively bind with monovalent cations, making it a versatile molecule in various applications.
Uses
Used in Pharmaceutical Industry:
2-(HYDROXYMETHYL)-12-CROWN 4-ETHER is used as a complexing agent for the preparation of an ester of lasalocid with crown ether. This complex formation with monovalent cations is crucial in studying the interactions and potential applications of the compound in the pharmaceutical field.
Used in Environmental Applications:
In the environmental sector, 2-(HYDROXYMETHYL)-12-CROWN 4-ETHER is used as a key component in the development of hydrogel adsorbents. These adsorbents are designed for the recovery of lithium ions from seawater, which is an essential process in the production of lithium-based batteries and other technologies.
Used in Chemical Synthesis:
2-(HYDROXYMETHYL)-12-CROWN 4-ETHER serves as a starting material in the synthesis of metal-free phthalocyanines and metallophthalocyanines. These compounds have a wide range of applications, including their use in solar cells, sensors, and as catalysts in various chemical reactions.
Used in Detergent Production:
Ethylene oxide, which is related to 2-(HYDROXYMETHYL)-12-CROWN 4-ETHER, is important or critical to the production of detergents. It is used as a building block for various organic chemicals, including ethylene glycol, ethanolamines, simple and complex glycols, polyglycol ethers, and other compounds that contribute to the formulation of detergents.
Used in Plastics and Solvent Industries:
Ethylene oxide, a related compound, is also critical in the production of thickeners, solvents, and plastics. The versatility of 2-(HYDROXYMETHYL)-12-CROWN 4-ETHER and its derivatives makes them valuable in these industries for the development of new materials and products.
Purification Methods
Purify it by chromatography on Al2O3 with EtOAc as eluent to give a hygroscopic colourless oil, which is distilled under high vacuum and is distilled in vacuo. It has IR: 3418 (OH) and 1103 (COC) cm-1, NMR: max 3.70s. [Kimura et al. J Chem Soc, Chem Commun 492 1983, Pugia et al. J Org Chem 52 2617 1987.] S -(-)-5-Hydroxymethyl -2(5 H )-furanone [78508-96 -0] M 114.1, 39 -42o, 40 -44o , b 1 3 0o/0.3mm, [ ] 546 -180o, [ ] D -148o (c 1.4, H2O). It is purified by chromatography on Silica gel using hexane/EtOAc (1:1) to give a colourless oil which is distilled using a Kügelrohr apparatus, and the distillate crystallises on cooling. It has RF 0.51 on Whatman No 1 paper using pentan-1-ol and 85% formic acid (1:1) and developing with ammoniacal AgNO3. [Boll Acta Chem Scand 22 3245 1968, NMR: Oppolzer et al. Helv Chim Acta 68 2100 1985, Beilstein 18 III/IV 56, 18/1 V 54.]
Check Digit Verification of cas no
The CAS Registry Mumber 75507-26-5 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 7,5,5,0 and 7 respectively; the second part has 2 digits, 2 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 75507-26:
(7*7)+(6*5)+(5*5)+(4*0)+(3*7)+(2*2)+(1*6)=135
135 % 10 = 5
So 75507-26-5 is a valid CAS Registry Number.
InChI:InChI=1/C9H18O5/c10-7-9-8-13-4-3-11-1-2-12-5-6-14-9/h9-10H,1-8H2
75507-26-5Relevant articles and documents
Facile Synthesis of Hydroxymethylcrown Ethers
Ikeda, Isao,Emura, Hiroshi,Okahara, Mitsuo
, p. 73 - 74 (2007/10/02)
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Synthesis of Substituted Crown Ethers from Oligoethylene Glycols
Ikeda, Isao,Yamamura, Shingo,Nakatsuji, Yohji,Okahara, Mitsuo
, p. 5355 - 5358 (2007/10/02)
A convenient synthetic method for preparing 12-crown-4, 15-crown-5, 18-crown-6, and 21-crown-7 bearing various substituents by intramolecular cyclization of the corresponding substituted oligoethylene glycols in high yields is described.Substituents include modifiable pendent groups such as phenyl and hydroxymethyl, as well as various alkyl groups.Stability constants for the new substituted crown ethers with sodium and potassium ions in methanol were determined by potentiometric titration.The absolute effect of pendent groups on stability constants was insignificant.
