75626-15-2

Basic information

• Product Name: <2-(2,5-difluoro-3,4-dimethoxyphenyl)ethyl>amine
• Synonyms: <2-(2,5-difluoro-3,4-dimethoxyphenyl)ethyl>amine
• CAS NO: 75626-15-2
• Molecular Weight: 217.216
• Mol File: 75626-15-2.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: <2-(2,5-difluoro-3,4-dimethoxyphenyl)ethyl>amine(CAS DataBase Reference)
• NIST Chemistry Reference: <2-(2,5-difluoro-3,4-dimethoxyphenyl)ethyl>amine(75626-15-2)
• EPA Substance Registry System: <2-(2,5-difluoro-3,4-dimethoxyphenyl)ethyl>amine(75626-15-2)

Safety Data

• Hazardous Substances Data: 75626-15-2(Hazardous Substances Data)

Upstream product

• 75626-19-6 1-Chloromethyl-2,5-difluoro-3,4-dimethoxy-benzene 
• 72912-50-6 5,8-difluoro-2,3-dihydro-1,4-benzodioxin 
• 75626-22-1 3,6-difluoro-2-hydroxyanisole 
• 75626-23-2 3,6-Difluorocatechol 
• 75626-17-4 2,5-difluoroanisole 
• 75626-18-5 1,4-difluoro-2,3-dimethoxybenzene 
• 72912-49-3 2-(2,3,6-trifluorophenoxy)ethanol 
• 2713-31-7 2,5-difluorophenol 
• 551-62-2 1,2,3,4-tetrafluorobenzene 
• 540-36-3 para-difluorobenzene 
• 75626-20-9 (2,5-Difluoro-3,4-dimethoxy-phenyl)-acetonitrile 

Downstream Products

• 104114-02-5 N-[2-(2,5-Difluoro-3,4-dimethoxy-phenyl)-ethyl]-2-hydroxy-2-(4-methoxy-phenyl)-acetamide 
• 104114-05-8 2-[2-(2,5-Difluoro-3,4-dimethoxy-phenyl)-ethylamino]-1-(4-methoxy-phenyl)-ethanol 
• 104114-08-1 6,9-Difluoro-7,8-dimethoxy-1-(4-methoxy-phenyl)-2,3,4,5-tetrahydro-1H-benzo[d]azepine 
• 104113-91-9 6,9-Difluoro-1-(4-hydroxy-phenyl)-2,3,4,5-tetrahydro-1H-benzo[d]azepine-7,8-diol; hydrobromide 
• 75626-16-3 <2-(2,5-difluoro-3,4-dimethoxyphenyl)ethyl>amine hydrobromide 

Relevant articles and documents

Synthesis of fluorodopamines: Effect of aryl fluoro substituents on affinities for adrenergic and dopaminergic receptors

Monofluorine-substituted dopamines (1b-d) have been prepared previously. Synthetic routes to di- and trifluorinated dopamines (1e-h) were based on side chain elaboration of precursor fluorinated veratraldehydes. Binding data indicate that a 6-fluoro substituent decreases affinity at D1-, D2-, D3- and D4-dopamine receptors with the reduction (14-fold) being greatest at the D2-dopamine receptor. A 2-fluoro or 5-fluoro substituent had little or no effect. Additional 2- and/or 5-fluoro substituents further reduced affinity of 6-fluorodopamine for dopamine receptors. At adrenergic receptors, mono-fluoro substituents had only modest (2-fold or less) effects on affinity, while 2,6-di-, and 5,6-difluoro substitution modestly decreased affinity. 2,5,6-Trifluorodopamine had very low affinity.