756843-99-9

Basic information

• Product Name: 3,17β-bis(benzyloxy)-11β-benzylthioestra-1,3,5(10)-triene
• Synonyms: 3,17β-bis(benzyloxy)-11β-benzylthioestra-1,3,5(10)-triene
• CAS NO: 756843-99-9
• Molecular Weight: 574.827
• Mol File: 756843-99-9.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 3,17β-bis(benzyloxy)-11β-benzylthioestra-1,3,5(10)-triene(CAS DataBase Reference)
• NIST Chemistry Reference: 3,17β-bis(benzyloxy)-11β-benzylthioestra-1,3,5(10)-triene(756843-99-9)
• EPA Substance Registry System: 3,17β-bis(benzyloxy)-11β-benzylthioestra-1,3,5(10)-triene(756843-99-9)

Safety Data

• Hazardous Substances Data: 756843-99-9(Hazardous Substances Data)

Upstream product

• 100-53-8 phenylmethanethiol 
• 756843-97-7 3,17β-bis(benzyloxy)-11α-methanesulfonylestra-1,3,5(10)-triene 
• 40128-87-8 11α-hydroxy-3,17β-dibenzyloxyoestra-1,3,5(10)-triene 

Downstream Products

• 756844-03-8 11β-benzylthioestra-1,3,5(10)-triene-3,17β-diol 

Relevant articles and documents

Estradiol derivatives bearing sulfur-containing substituents at the 11β or 7α positions: Versatile reagents for the preparation of estrogen conjugates

Estradiol derivatives bearing HS-, HSCH2-, HSCH 2CH2-, MeS-, MeSCH2-, MeSCH2CH 2-, or PhCH2SCH2CH2-groups at the 11β position or an HS-group at the 7α position have been synthesized, and their binding affinity to the estrogen receptor (ER) determined. Nearly all of these substituted estrogens retain high binding affinity, and at the 11β position, the sulfur atom has an effect on ER binding that is similar to that of a carbon atom. These thiol derivatives are promising intermediates for the preparation of a variety of estradiol conjugates. The methyl sulfides, in particular, might potentially be developed as 11C-labeled agents for imaging ER-positive tumors by positron emission tomography.