75799-18-7Relevant articles and documents
Synthesis and antitumor activities of naturally occurring oleanolic acid triterpenoid saponins and their derivatives
Liu, Qingchao,Liu, Hongchun,Zhang, Lei,Guo, Tiantian,Wang, Peng,Geng, Meiyu,Li, Yingxia
, p. 1 - 15 (2013/07/11)
Twenty-six naturally occurring oleanolic acid saponins and their derivatives, 16 of which were synthesized in this study, were preliminarily evaluated against human cancer cells. From SAR studies, the presence of α-l-rhamnosyl residue at the terminal of both C-3 and C-28 position for oleanolic acid bidesmosides was important to enhance cytotoxicity, and introducing more sugar residues at C3-OH of compound 12 with C-28 carboxylic acid is a favorable modification to ameliorate the anticancer activity. Furthermore, α-l-rhamnosyl moiety linked to C2-OH of the first monosaccharide (α-l-alabinose, β-d-xylose, β-d-galactose or β-d-glucose) in C3-OH of oleanolic acid was helpful to improve the cytotoxicity. According to the predicted log P values, lipophilicity of the synthesized saponins was not an important factor for cytotoxicity.
TRITERPENE GLYCOSIDES AND THEIR GENINS FROM Thalictrum foetidum. I. THE STRUCTURE OF FOETOSIDE C
Ganenko, T. V.,Isaev, M. I.,Gorovits, T. T.,Gromova, A. S.,Lutskii, V. I.,et al.
, p. 433 - 438 (2007/10/02)
A new glycoside - foetoside C - has been isolated from the epigeal part of Thalictrum foetidum L. and, on the basis of chemical transformations and spectral characteristics its structure has been established as oleanolic acid 28-6)-O-β-D-glucopyranoside> 3-O-3)-O-α-L-rhamnopyranosyl-(1->2)-α-L-arabinopyranoside>.
Studies on the constituents of Clematis species. III. On the saponins of the root of Clematis chinensis Osbeck
Kizu,Tomimori
, p. 3555 - 3560 (2007/10/02)
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